Pharmacological Mechanisms And The Modulation Of Pain

Pharmacological Mechanisms and the Modulation of Pain, the newest volume in the Advances in Pharmacology series, presents the pharmacological mechanisms and the modulation of pain. With a variety of chapters and the best authors in the field, this volume is an essential resource for pharmacologists, immunologists, and biochemists alike. Contains contributions from the best authors in the field of pharmacology that focus on the pharmacological mechanisms and modulation of pain Provides an essential resource for pharmacologists, immunologists, and biochemists

This volume represents edited material that was presented at a conference on brainstem modulation of spinal nociception held in Beaune, France during July, 1987. Pain Modulation, Volume 77 in the series Progress in Brain Research reviews, analyses and suggests new research strategies on several relevant topics including: the endogenous opioid peptides; sites of action of opiates; the role of biogenic animes and non-opioid peptides in analgesia; dorsal horn circuitry; behavioural factors in the activation of pain modulating networks and clinical studies of nociceptive modulation.

Pharmacology of Pain provides a complete review of the pharmacology of pain, including mechanisms of drug actions, clinical aspects of drug usage, and new developments. This authoritative book describes the different systems involved in the perception, transmission, and modulation of pain and discusses the available options for pharmacological treatment of pain. Who should buy this book? Pharmacology of Pain is a particularly useful resource for: Basic researchers and clinicians, including physicians, dentists, pharmacists, nurses, and physical therapists Other professionals in the field of pain research and treatment Students and trainees

This book deals with physiological, neurophysiological, and psychological aspects of the mechanisms and treatment of pain. It also provides information on the latest research results regarding the influence of age and gender on the perception of pain. Finally, it presents the basic mechanisms of analgesia in terms of pharmacological and nonpharmacological treatments.

Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.

Local-regional anesthesia and pain therapy represent two areas of common interest for all physicians. A thorough preparation in functional anatomy and general pharmacology, including familiarity with local anesthetics and analgesics, is considered fundamental background for further study or clinical application of such techniques. Knowledge of the mechanisms of action, efficacies and side effects of the relevant drugs is essential, as is appreciation of possible drug interactions to evaluate eventual toxic effects. Local-regional anesthesia and pain management are being increasing used in diverse medical specialties, including those requiring manual dexterity. In contemporary medicine correct evaluation of the medical outcome becomes essential, especially in relation to the cost-benefit balance, not only in terms of the resources consumed, also and more importantly for the quality of life of the patient.

New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.

Of related interest . . . Neuronal Nicotinic Receptors Pharmacology and Therapeutic Opportunities Edited by Stephen P. Arneric and Jorge D. Brioni Providing a comprehensive review of nicotinic receptors, this reference examines all aspects-from the molecular level to clinical applications. The editors cover the emerging molecular biological advances in the cloning of nAChRs, as well as the localization and regulation of these receptors, and the role these receptors have in central nervous system (CNS) disorder functions. Additionally, examined areas include in vivo pharmacology, and the therapeutic opportunities existing for agents that selectively interact with these receptors to treat CNS disorders. 1999 (0-471-24743-X) 440 pp. Purinergic Approaches in Experimental Therapeutics Edited by Kenneth A. Jacobson and Michael F. Jarvis Purinergic receptors are a type of neuroreceptor that has been found to have unique therapeutic potential as a chemical compound in the treatment of many neurological disorders such as Alzheimer's disease, chronic pain, Parkinson's disease, stroke, thrombosis, bladder function, stress, and cancer. This book covers the molecular pharmacology, medicinal chemistry, and experimental therapeutics of purinergic compounds. 1997 (0-471-14071-6) 600 pp.