Platelet Rich Plasma Basic Science And Clinical Applications In Orthopedics

Platelet-rich plasma, popularly called PRP, is a fraction of autologous blood plasma containing concentrated platelets. PRP has gained increasing interest for its dramatic benefits in the treatment of musculoskeletal injuries, especially for some refractory diseases such as pressure ulcers, diabetic foot ulcers, tendinopathy, or osteoarthritis. High concentrations of autologous growth factors released from activated PRP compensate for the deficiency of growth factors in these refractory diseases. In addition to the advantages of providing high concentrations of growth factors, PRP therapy also has the advantages of being safe, simple and effective in treating a wide range of acute and chronic musculoskeletal diseases. To date, PRP has been used in a variety of clinical practices for tissue repair and regeneration, pain relief, and to delay or even avoid the choice of surgery. This book covers a variety of topics from basic science to clinical applications and is suitable for both freshmen and experienced physicians interested in PRP therapy.

This book offers a comprehensive overview of the use of platelet rich plasma (PRP), typically by injection, and its usage across medical disciplines. This multi-authored, multi-institutional, and multi-specialty based text is designed to guide health care providers in the varied uses of PRP -- starting from its history and preparation and moving through a variety of disciplines to illustrate how PRP can help healing. Clinical Applications of Platelet Rich Plasma in Medicine is divided into three sections: The first gives an overview of the basic science of PRP; the second provides a detailed overview of the clinical indications of PRP; and the third section discusses potential complications in conjunction with relevant case studies. It will feature a wealth of images and diagrams to illustrate best practices in using PRP. Written to be used by oral and maxillofacial surgeons, plastic surgeons, cosmetic surgeons, otolaryngologists, dentists, orthopedic surgeons, and general surgeons to name a few, this book will provide an evidence-based approach to using PRP in practice. The editors have extensive academic experience and have authored multiple scientific publications, while the contributions included in the text have been written by experts and leaders in the fields touched upon in the book.

This book provides a comprehensive, state-of-the art summary of platelet rich plasmas (PRPs) in the field of regenerative medicine. The book begins with an overview of the basic science behind PRP, describing the role of platelets and growth factors followed by the most important biological effects expected from the use of PRPs. Platelet Rich Plasma in Orthopaedics, Sports Medicine and Maxillofacial Surgery includes numerous contributions detailing the current use of PRPs in clinical practice. From the origins in oral and maxillofacial surgery, to the latest advances in orthopaedics and sports medicine including the use of Platelet Rich Growth Factors (PRGF) in muscle, bone, tendon, ligament and nerve injuries, this book provides a wide scope of the topic. The volume concludes with chapters from experts in biology, orthopaedics, oral and maxillofacial surgery, where the convergence of expertise is leading to unprecedented insights into how to minutely control the in vivo fate and function of PRGF. This book will provide a useful resource for physicians and researchers interested in learning more about this rapidly growing area of biomedical treatment.

Platelet-Rich Plasma (PRP) has gained tremendous popularity in recent years as a treatment option for specialties including Orthopedics, Dentistry, Sports Medicine, Otorhinolaryngology, Neurosurgery, Ophthalmology, Urology, Vascular, Cardiothoracic and Maxillofacial Surgery, and Veterinarian Medicine. Nowadays, PRP and Stem Cell Science have added an exciting dimension to tissue repair. This book begins by giving the reader a broad overview of current progress as well as a discussion of the technical aspects of preparation and therapeutic use of autologous PRP. It is followed by a review of platelet structure, function and major growth factors in PRP (PDGF and TGFβ).The third chapter outlines the basic principles of biochemical cellular metabolism that increases the efficacy of PRP. Analogous to the preparation of soil for a garden, restoring cellular health should be the first consideration in Regenerative Medicine. Standardization of PRP preparation to clinical use still remains a challenging prospect. In this sense, a feasible strategy for studying PRP preparation is illustrated, which also allows to modulate and tailor the quality of PRP for further clinical applications. The science behind PRP and stem cells, on tissue regeneration, cell proliferation and mesenchyme stem-cells are emphasized and reviewed. Various specific uses of PRP are described with detailed illustrations of various personal experiences mainly in orthopedic injuries, ligament and tend on repair, degenerative diseases, sports medicine, chronic wound healing as well as rehabilitation aspects in tendinopathy. Expertly written by leading scientists in the field, this book provides for beginners and experienced readers scientific fundamentals, the state of art of PRP, specific uses and personal experiences with a practical approach and reference for current trends in use. Finally, this book paves the way for future developments.

This book provides an introductory overview of advancements in platelet-rich plasma (PRP), focusing on current technologies and methods, new challenges and controversies, and avenues for further research. With many studies demonstrating a role for PRP in improving response to injury, this book aims to facilitate the application of this rapidly growing treatment option for trauma patients. Platelet Rich Plasma in Musculoskeletal Practice is a highly informative and carefully presented book, providing scientific and clinical insight for specialists who utilize PRP in daily practice, and for readers who are seeking to learn more about this effective injury treatment.

From clinical application to experimental research, this book summarizes the transformation value of Platelet-Rich Plasma, explores its potential research hotspots, and ultimately serves the clinic. On the one hand, the main content of this work is to explain the research progress of Platelet-Rich Plasma in the laboratory, including the mechanisms involved in its research and possible potential therapeutic effects. On the other hand, this work aims to clarify its application foundation and value in Aesthetic Surgery. The purpose is to provide reliable reference tools for relevant work practitioners, build a bridge between experimental research and clinical application, and promote the progress of Platelet-Rich Plasma-related translational medicine.

Designed with the practicing clinician in mind, Biologics in Orthopaedic Surgery provides a succinct, easy-to-digest overview of the integration of biologics (platelet-rich-plasma [PRP], bone marrow aspirate [BMA], and stem cells) into today’s orthopaedic practice. Covering relevant basic science as well as clinical applications, this concise reference takes a head-to-toe approach to the emerging role of orthobiologics for specific conditions and procedures, in addition to future directions for implementation.

21st Century belongs to Biologics. The Regenerative Medicine is the biggest “Game-Changer” in the history of Medicine. Stem Cells and Cellular therapy are going to lead the future cures. Platelet Rich Plasma (PRP) leads this transformation through successful clinical applications. The PRP is the newer solutions for complex unsolved health problems, including infections and gangrenes. The Ease of preparation, safety and presence of growth factors will make it, one of the most successful health solution. The PRP is very exciting and intriguing to work with. This book is written with intent to gain insight into world of PRP. It includes the detail PRP therapy; for Wounds, Osteoarthritis, Tendinopathies, Fracture Impairments and Infertility, with guidance to do it. It is with intention, to “Self-Train” health care providers; navigating through illustrations and examples. The Science of Medicine is changing, this book offers opportunity to lead the change with confidence. The book is lucidly written for everyone, to understand Platelet Rich Plasma. It is meant for all. What Penicillin did in 20th Century, PRP will do in 21st Century.