Platelet Rich Plasma In Tissue Repair And Regeneration

From clinical application to experimental research, this book summarizes the transformation value of Platelet-Rich Plasma, explores its potential research hotspots, and ultimately serves the clinic. On the one hand, the main content of this work is to explain the research progress of Platelet-Rich Plasma in the laboratory, including the mechanisms involved in its research and possible potential therapeutic effects. On the other hand, this work aims to clarify its application foundation and value in Aesthetic Surgery. The purpose is to provide reliable reference tools for relevant work practitioners, build a bridge between experimental research and clinical application, and promote the progress of Platelet-Rich Plasma-related translational medicine.

Platelet-Rich Plasma (PRP) has gained tremendous popularity in recent years as a treatment option for specialties including Orthopedics, Dentistry, Sports Medicine, Otorhinolaryngology, Neurosurgery, Ophthalmology, Urology, Vascular, Cardiothoracic and Maxillofacial Surgery, and Veterinarian Medicine. Nowadays, PRP and Stem Cell Science have added an exciting dimension to tissue repair. This book begins by giving the reader a broad overview of current progress as well as a discussion of the technical aspects of preparation and therapeutic use of autologous PRP. It is followed by a review of platelet structure, function and major growth factors in PRP (PDGF and TGFβ).The third chapter outlines the basic principles of biochemical cellular metabolism that increases the efficacy of PRP. Analogous to the preparation of soil for a garden, restoring cellular health should be the first consideration in Regenerative Medicine. Standardization of PRP preparation to clinical use still remains a challenging prospect. In this sense, a feasible strategy for studying PRP preparation is illustrated, which also allows to modulate and tailor the quality of PRP for further clinical applications. The science behind PRP and stem cells, on tissue regeneration, cell proliferation and mesenchyme stem-cells are emphasized and reviewed. Various specific uses of PRP are described with detailed illustrations of various personal experiences mainly in orthopedic injuries, ligament and tend on repair, degenerative diseases, sports medicine, chronic wound healing as well as rehabilitation aspects in tendinopathy. Expertly written by leading scientists in the field, this book provides for beginners and experienced readers scientific fundamentals, the state of art of PRP, specific uses and personal experiences with a practical approach and reference for current trends in use. Finally, this book paves the way for future developments.

This Special Issue on “Blood-Derived Products for Tissue Repair and Regeneration” reveals the evolution and diversity of platelet rich plasma (PRP) technologies, which includes experimental research on novel formulations, the creation of combination therapies, and the exploration of potential modifiers of PRPs, as well as efficacy of PRP therapies in clinical veterinary and human applications. Scientist and clinicians are now starting to develop different treatments based on their reinterpretation of the traditional roles of platelets and plasma, and the current Issue has provided a forum for sharing research and ways of understanding the associated medicinal benefits from different points of view. The research interest in this area has covered different medical disciplines, such as ophthalmology, dentistry, orthopedics, and sports medicine.

Over the recent years, biotechnology has become responsible for explaining interactions of biological tools and processes so that many scientists in the life sciences from agronomy to medicine are engaged in biotechnological research. This book contains an overview focusing on the research area of molecular biology, molecular aspects of biotechnology, synthetic biology and agricultural applications in relevant approaches. The book deals with basic issues and some of the recent developments in biotechnological applications. Particular emphasis is devoted to both theoretical and experimental aspect of modern biotechnology. The primary target audience for the book includes students, researchers, biologists, chemists, chemical engineers and professionals who are interested in associated areas. The book is written by international scientists with expertise in chemistry, protein biochemistry, enzymology, molecular biology and genetics, many of which are active in biochemical and biomedical research. We hope that the book will enhance the knowledge of scientists in the complexities of some biotechnological approaches; it will stimulate both professionals and students to dedicate part of their future research in understanding relevant mechanisms and applications.

This Special Issue on “Blood-Derived Products for Tissue Repair and Regeneration” reveals the evolution and diversity of platelet rich plasma (PRP) technologies, which includes experimental research on novel formulations, the creation of combination therapies, and the exploration of potential modifiers of PRPs, as well as efficacy of PRP therapies in clinical veterinary and human applications. Scientist and clinicians are now starting to develop different treatments based on their reinterpretation of the traditional roles of platelets and plasma, and the current Issue has provided a forum for sharing research and ways of understanding the associated medicinal benefits from different points of view. The research interest in this area has covered different medical disciplines, such as ophthalmology, dentistry, orthopedics, and sports medicine.

This book offers a comprehensive overview of the use of platelet rich plasma (PRP), typically by injection, and its usage across medical disciplines. This multi-authored, multi-institutional, and multi-specialty based text is designed to guide health care providers in the varied uses of PRP -- starting from its history and preparation and moving through a variety of disciplines to illustrate how PRP can help healing. Clinical Applications of Platelet Rich Plasma in Medicine is divided into three sections: The first gives an overview of the basic science of PRP; the second provides a detailed overview of the clinical indications of PRP; and the third section discusses potential complications in conjunction with relevant case studies. It will feature a wealth of images and diagrams to illustrate best practices in using PRP. Written to be used by oral and maxillofacial surgeons, plastic surgeons, cosmetic surgeons, otolaryngologists, dentists, orthopedic surgeons, and general surgeons to name a few, this book will provide an evidence-based approach to using PRP in practice. The editors have extensive academic experience and have authored multiple scientific publications, while the contributions included in the text have been written by experts and leaders in the fields touched upon in the book.

Platelet-rich plasma, popularly called PRP, is a fraction of autologous blood plasma containing concentrated platelets. PRP has gained increasing interest for its dramatic benefits in the treatment of musculoskeletal injuries, especially for some refractory diseases such as pressure ulcers, diabetic foot ulcers, tendinopathy, or osteoarthritis. High concentrations of autologous growth factors released from activated PRP compensate for the deficiency of growth factors in these refractory diseases. In addition to the advantages of providing high concentrations of growth factors, PRP therapy also has the advantages of being safe, simple and effective in treating a wide range of acute and chronic musculoskeletal diseases. To date, PRP has been used in a variety of clinical practices for tissue repair and regeneration, pain relief, and to delay or even avoid the choice of surgery. This book covers a variety of topics from basic science to clinical applications and is suitable for both freshmen and experienced physicians interested in PRP therapy.

21st Century belongs to Biologics. The Regenerative Medicine is the biggest “Game-Changer” in the history of Medicine. Stem Cells and Cellular therapy are going to lead the future cures. Platelet Rich Plasma (PRP) leads this transformation through successful clinical applications. The PRP is the newer solutions for complex unsolved health problems, including infections and gangrenes. The Ease of preparation, safety and presence of growth factors will make it, one of the most successful health solution. The PRP is very exciting and intriguing to work with. This book is written with intent to gain insight into world of PRP. It includes the detail PRP therapy; for Wounds, Osteoarthritis, Tendinopathies, Fracture Impairments and Infertility, with guidance to do it. It is with intention, to “Self-Train” health care providers; navigating through illustrations and examples. The Science of Medicine is changing, this book offers opportunity to lead the change with confidence. The book is lucidly written for everyone, to understand Platelet Rich Plasma. It is meant for all. What Penicillin did in 20th Century, PRP will do in 21st Century.