Polycyclic Aromatic Hydrocarbons

This book reviews Polycyclic Aromatic Hydrocarbons (PAHs) and Nitropolycyclic Aromatic Hydrocarbons (NPAHs) contamination in the context of environmental pollution in Asia. It is comprised of the following sections: 1. Fundamental Chemistry and General Characteristics; 2. Analytical Methods; 3. Emission Source and Atmospheric Behavior; 4. Atmospheric Polycyclic Aromatic Hydrocarbons and PM2.5; 5. Polycyclic Aromatic Hydrocarbons in Marine Environments; 6. Metabolic Activation/Toxicities; and 7. Environmental Standards and Guidelines. This volume concentrates on the Far East due to the massive consumption of coal and petroleum in China, which has led to considerable levels of air pollution. High concentration of atmospheric PM2.5 in Beijing have been reported since January 2013 and exposure to such high concentrations may cause respiratory, cardiac and lung diseases. Gathering contributions from international experts, this volume provides a valuable reference guide for global researchers and students interested in learning from the East Asian experience.

This 1991 volume was the first to review the chemical properties of the carcinogenic polycyclic aromatic hydrocarbons.

This book presents WHO guidelines for the protection of public health from risks due to a number of chemicals commonly present in indoor air. The substances considered in this review, i.e. benzene, carbon monoxide, formaldehyde, naphthalene, nitrogen dioxide, polycyclic aromatic hydrocarbons (especially benzo[a]pyrene), radon, trichloroethylene and tetrachloroethylene, have indoor sources, are known in respect of their hazardousness to health and are often found indoors in concentrations of health concern. The guidelines are targeted at public health professionals involved in preventing health risks of environmental exposures, as well as specialists and authorities involved in the design and use of buildings, indoor materials and products. They provide a scientific basis for legally enforceable standards.

This book provides an overview on the molecular mode of action of carcinogenic polycyclic aromatic hydrocarbons (PAHs). PAHs are by-products arising from incomplete combustion of organic matter that are frequently released into our environment, and thus are ubiquitously detectable. Many PAHs are strong carcinogens in rodent bioassays and have been linked to increased incidences of various types of cancer in humans. The present book covers all aspects of PAH-induced carcinogenesis; it is a collection of articles written by some of the most recognizable PAH researchers, reviewing the present knowledge in this field. The topics include: exposure to and biomonitoring of PAHs in the human population; metabolic activation of PAHs; genotoxicity and repair of PAH-induced DNA damage; and factors modulating individual susceptibility to the deleterious effects of PAHs. Contents:Polycyclic Aromatic Hydrocarbon-Induced Carcinogenesis — An Introduction (A Luch)Metabolic Activation and Detoxification of Polycyclic Aromatic Hydrocarbons (A Luch & W M Baird)Biomonitoring of Polycyclic Aromatic Hydrocarbons — Human Exposure (A Seidel)Macromolecular Adducts as Biomarkers of Human Exposure to Polycyclic Aromatic Hydrocarbons (D H Phillips)DNA Damage and Mutagenesis Induced by Polycyclic Aromatic Hydrocarbons (A Besaratinia & G P Pfeifer)Mechanisms of Repair of Polycyclic Aromatic Hydrocarbon-Induced DNA Damage (H Naegeli & N E Geacintov)Aberrant Gene Expression and Cell Signalling/Epigenetic Effects Induced by Polycyclic Aromatic Hydrocarbons (P Steinberg)Indicator Assays for Polycyclic Aromatic Hydrocarbon-Induced Genotoxicity (H Glatt)Tumorigenicity of Polycyclic Aromatic Hydrocarbons (S Amin & K El-Bayoumy)Genetic Susceptibility to Polycyclic Aromatic Hydrocarbon-Induced Carcinogenesis (A Hirvonen)Polycyclic Aromatic Hydrocarbon-Induced Carcinogenesis — An Integrated View (A Luch) Readership: Graduate students, academics and researchers in toxicology, biochemistry, oncology and the life sciences. Keywords:PAH;Polycyclic Aromatic Hydrocarbon;Carcinogenesis;Genotoxicity

Polycyclic aromatic hydrocarbons (PAHs) are chemical compounds that consist of fused aromatic rings and do not contain heteroatoms or carry substituents. PAHs are one of the most widespread organic pollutants. Their occurrence is largely a result of anthropogenic and natural emissions such as fossil fuel-burning, motor vehicle, waste incinerator, oil refining, coke and asphalt production, and aluminum production. This book examines recent developments in the field.

This volume concerns sources of polycyclic aromatic hydrocarbons (PAH), their emission factors, and relative importance. It deals with exposure, uptake, metabolism, and detection of PAH in the human body. The volume contains an update of information in environmental and biochemical studies of PAH.