Polyendocrine Disorders And Endocrine Neoplastic Syndromes

This comprehensive reference book is meant to support clinicians in the diagnosis and treatment of polyendocrine diseases and endocrine neoplastic syndromes. Although a large majority of endocrine diseases present as sporadic cases, an increasing proportion can be identified as part of a polyendocrine or systemic syndrome. These include autoimmune endocrine diseases, which may be part of autoimmune polyendocrine disorders (APS) or rare complex disorders such as POEMS (polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes) or IPEX (immune dysregulation, polyendocrinopathy, enteropathy, X-linked) syndromes. On the other hand, endocrine tumors may develop in a variety of clinical conditions, including multiple endocrine neoplasia (MEN) syndromes, syndromic diseases such as McCune Albright or Carney’s complex, or peculiar familial associations such as pheochromocytoma/paraganglioma syndromes. The book discusses the significant advances that have been made in the clinical and genetic characterization of such entities, with major implications in terms of diagnosis and clinical management - with special attention to emerging syndromes, familial screening , multidisciplinarity and multimodal treatment. This volume is intended for clinicians, residents, specialists and physicians involved in the diagnosis and treatment of affected patients, including specialists in endocrinology, internal medicine, oncology , genetics and imaging.

From classic MEN syndromes to various germline and somatic mutations in sporadic tumors In these times, a book should aspire to present the most significant advances in the field, reflect the themes of the moment, and provide a useful compendium for future reference. This book accomplishes all three objectives by discussing the changing world of modern genetics in endocrine tumors and its impact on clinical practice. Clinicians have to incorporate modern genetics and systems biology in their daily practice. Educators and researchers have to introduce molecular pathways and their genetic variability in their teaching, as well as understanding of classic physiology and pathophysiology. Taking these aspects into account, the chapters in this book cover both the classic multiple endocrine neoplasia (MEN) syndromes, as well as newly described ones, such as Carney triad and Carney- Stratakis syndrome. Furthermore, the genetics of paragangliomas as well as thyroid, parathyroid, and pituitary tumors are examined. Outlining the latest research and its obvious implications for our understanding the genetics of endocrine tumor formation and molecular biology of cancer and their potential therapeutic implications, this book is not only useful for researchers but even more so for practicing clinicians, in particular internists, endocrinologists, oncologists, pediatricians, surgeons, pathologists, geneticists, and genetic counselors.

The genetics of endocrine cancers is clearly an area where new scientific discoveries that have occurred in the past few years have already been translated into clinical practice. This volume attempts to provide a state-of-the-art review of some of the most relevant inherited syndromes that share a higher susceptibility to the development of endocrine tumors. It focuses on familial tumor syndromes for which the primary gene defect has been well characterized or recently identified. An overview of cloning strategies and gene characterization in cancer, is combined with detailed discussions of clinical aspects and molecular features of heritable endocrine neoplastic diseases, such as MEN1 and MEN2 and Von Hippel-Lindau disease. Studies on the PTEN gene, the first known phosphatase to lead to cancer when disrupted are discussed in detail. Also included disrupted is the recent identification and partial characterization of one of at least two genes for Carney Complex, PRKARIA. The authors place special emphasis on testing and screening strategies which now allow a much earlier identification of family members at risk. The challenge for the 21st century will be to develop equal progress in pharmacological prevention and cure based on the knowledge of the function of these susceptibility genes and their targets.

The disorders of the endocrine system are known as endocrine disorders. Major endocrine glands are the pineal and the pituitary glands, the thymus, thyroid gland, adrenal gland, the pancreas and the ovary and the testes. Endocrine disorders include endocrine gland hypersecretion that leads to excessive hormone production, endocrine gland hyposecretion which leads to hormone deficit, and benign or malignant tumors of the endocrine glands. When abnormal chemical reactions occur in the body and alters the normal metabolic process of the body, it results in a metabolic disorder. It is an inherited genetic condition that creates an enzyme deficiency. The symptoms of metabolic disorders can be categorized as acute, progressive general, late-onset acute and permanent. Some common symptoms are weight loss, lethargy, seizures and jaundice. This book contains some path-breaking studies related to endocrine and metabolic disorders. It unravels the recent studies in the diagnosis, prevention and management of these disorders. For all readers who are interested in these domains, the case studies included in this book will serve as an excellent guide to develop a comprehensive understanding.

The state-of-the-art, tenth edition of endocrinology's classic text bridges the gap between basic science and endocrinology clinical practice. Thoroughly revised and updated, it includes new material on the thyroid and diabetes mellitus to reflect today's explosive increase in knowledge. Written by an outstanding team of authors, the 10th edition features numerous new authors who provide fresh perspectives. Presents a wealth of clinical information in a manageable size and format Contributors are at the forefronts of their disciplines Serves as a bridge between basic science and clinical endocrinology Diabetes mellitus and it complications has been greatly expanded and now includes 3 separate chapters. 4 new chapters Two new editors provide a fresh perspective on the material Figures have been added to the Diabetes Mellitus chapters Much of the art has been revised and includes new algorithms in many chapters Access to abstracts is available through Medline With 71 expert contributors

Endocrine Pathophysiology offers a comprehensive introduction to diseases of the endocrine system. Rather than providing an overwhelming amount of content on one subject, this book serves as a bridge between basic endocrine physiology and endocrine disorders. Included in the text are case studies covering a variety of endocrine disorders in both inpatient and outpatient settings. With the changes in many medical school curriculums to a clinically-based curriculum, this book provides a cutting-edge approach to endocrine pathophysiology.

During the last three decades, many laboratories worldwide have dedicated their research activities to understanding the roles of the cerebellum in motor control, cognitive processes and the biology of mental processes, behavioral symptoms and emotion. These advances have been associated with discoveries of new clinical disorders, in particular in the field of genetic ataxias, and the growing number of diseases presents a source of difficulty for clinicians during daily practice. This practical guide summarizes and evaluates current knowledge in the field of cerebellar disorders. Encompassing details of both common and uncommon cerebellar ataxias, including vascular, immune, neoplastic, infectious, traumatic, toxic and inherited disorders, this book will assist clinicians in the diagnosis and management of the full spectrum of cerebellar ataxias encountered in daily practice. Essential reading for clinicians, including general practitioners, neurologists, pediatricians, radiologists, psychiatrists and neuropsychologists, this will also prove a valuable tool for students, trainees and researchers.

Also the 3rd edition of "Dermatology" covers all the classical and related fields of dermatology, providing a wealth of information on diagnostic methods, clinical features, pathophysiology, and differential diagnosis. About 950 excellent photos and diagrams help the reader become acquainted with the immense variety of dermatological diseases. The contents of all chapters have been updated. New chapters have been included covering numerous subjects, e.g. dermatopathology, sonography, disorders of chromosomal instability and defective DNA repair, aging skin, sport dermatology, aesthetic therapy. The book is a must for every doctor confronted with dermatological problems.