Polymer Supported Reactions In Organic Synthesis

Polymers as Aids in Organic Chemistry covers the broad classifications and application of polymers in organic chemistry. This book is organized into 15 chapters that focus on the transformation of polymers and their role in other reagents that must be easily separated from their final product. After a brief introduction to polymer chemistry, the book presents a tabulation of the various types of polymers that have been used and the methods for their characterization. It then discusses the use of polymers as supports in peptide, oligonucleotide, and oligosaccharide chemistry; in peptide sequencing; in monofunctionalized difunctional compounds preparation, as aids in asymmetric syntheses; and as trapping agents in the determination of reaction intermediates. The subsequent chapters describe the use of polymers as catalysts, with particular emphasis on transition metals immobilized in the polymer matrix and used as catalysts. The concluding chapters examine polymer-immobilized compounds, enzymes, and whole cells that have been used to carry out a large number of reaction, most of which impinge on the area of organic chemistry. Polymer scientists and researchers and organic chemists will find this book invaluable.

Polymer supported chemical reactions may include those using supported substrates, reagents and catalysts, and this report describes all three types. In all cases the most frequent reason for the use of a polymeric support will be the ease of separation of the supported and the low molecular c099 species. An additional indexed section containing several hundred abstracts from the Rapra Polymer Library database provides useful references for further reading.

Polymer-supported organic catalysts are largely insoluble in most reaction solvents, which allows for easy recovery and recycling of the catalysts. They are generally stable, readily available, and environmental friendly, so they have attracted the interest of many synthetic chemists in the industrial and academic fields. In this book, different types of polymer-supported catalysts based on peptides, polystyrene, polyethers, poly(acrylic acid), poly(ethylene imine), poly(2-oxazoline), poly(isobutylene), poly(norbornene), etc., as well as metals are included with their synthetic organic synthesis applications. It is believed that this work will be of interest to organic chemists, material scientists, chemical engineers, polymer scientists and technologists.

Examines recent advances in the use of polymeric reagents and catalysts with a special emphasis on new compounds, synthetic methods, and industrial processes. Brings these advances to the attention of those who are involved in organic synthesis and desire a more thorough understanding of polymers and polymeric reagents. Contains comprehensive chapters devoted to polymeric oxidizing agents, Wittig reagents, and synthesis of cross-linked polymeric templates for chiral recognition. Presents opportunities for invention and use of many new polymeric reagents and catalysts.

This is the first book to describe the synthesis and characterization of the materials used in polymer-supported synthesis. The authors cover not only the classical polymers and their use in homogeneous, heterogeneous and micellar catalysis, but also such new developments as "enzyme-labile linkers", illustrating how to simplify the purification process and avoid waste. The result is a wealth of useful information -- for beginners and experts alike - in one handy reference, removing the need for difficult and time-consuming research among the literature.

Presents both the fundamental concepts and the most recent applications in solid-phase organic synthesis With its emphasis on basic concepts, Solid-Phase Organic Synthesis guides readers through all the steps needed to design and perform successful solid-phase organic syntheses. The authors focus on the fundamentals of heterogeneous supports in the synthesis of organic molecules, explaining the use of a solid material to facilitate organic synthesis. This comprehensive text not only presents the fundamentals, but also reviews the most recent research findings and applications, offering readers everything needed to conduct their own state-of-the-art science experiments. Featuring chapters written by leading researchers in the field, Solid-Phase Organic Synthesis is divided into two parts: Part One, Concepts and Strategies, discusses the linker groups used to attach the synthesis substrate to the solid support, colorimetric tests to identify the presence of functional groups, combinatorial synthesis, and diversity-oriented synthesis. Readers will discover how solid-phase synthesis is currently used to facilitate the discovery of new molecular functionality. The final chapter discusses how using a support can change or increase reaction selectivity. Part Two, Applications, presents examples of the solid-phase synthesis of various classes of organic molecules. Chapters explore general asymmetric synthesis on a support, strategies for heterocyclic synthesis, and synthesis of radioactive organic molecules, dyes, dendrimers, and oligosaccharides. Each chapter ends with a set of conclusions that underscore the key concepts and methods. References in each chapter enable readers to investigate any topic in greater depth. With its presentation of basic concepts as well as recent findings and applications, Solid-Phase Organic Synthesis is the ideal starting point for students and researchers in organic, medicinal, and combinatorial chemistry who want to take full advantage of current solid-phase synthesis techniques.