Practical Medicinal Chemistry With Macrocycles
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Practical Medicinal Chemistry with Macrocycles
Author | : Eric Marsault,Mark L. Peterson |
Publsiher | : John Wiley & Sons |
Total Pages | : 617 |
Release | : 2017-09-12 |
Genre | : Science |
ISBN | : 9781119092568 |
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Including case studies of macrocyclic marketed drugs and macrocycles in drug development, this book helps medicinal chemists deal with the synthetic and conceptual challenges of macrocycles in drug discovery efforts. Provides needed background to build a program in macrocycle drug discovery –design criteria, macrocycle profiles, applications, and limitations Features chapters contributed from leading international figures involved in macrocyclic drug discovery efforts Covers design criteria, typical profile of current macrocycles, applications, and limitations
Practical Medicinal Chemistry with Macrocycles
Author | : Eric Marsault,Mark L. Peterson |
Publsiher | : John Wiley & Sons |
Total Pages | : 624 |
Release | : 2017-08-03 |
Genre | : Science |
ISBN | : 9781119092582 |
Download Practical Medicinal Chemistry with Macrocycles Book in PDF, Epub and Kindle
Including case studies of macrocyclic marketed drugs and macrocycles in drug development, this book helps medicinal chemists deal with the synthetic and conceptual challenges of macrocycles in drug discovery efforts. Provides needed background to build a program in macrocycle drug discovery –design criteria, macrocycle profiles, applications, and limitations Features chapters contributed from leading international figures involved in macrocyclic drug discovery efforts Covers design criteria, typical profile of current macrocycles, applications, and limitations
The Practice of Medicinal Chemistry
Author | : Camille Georges Wermuth,David Aldous,Pierre Raboisson,Didier Rognan |
Publsiher | : Elsevier |
Total Pages | : 903 |
Release | : 2015-07-01 |
Genre | : Science |
ISBN | : 9780124172135 |
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The Practice of Medicinal Chemistry, Fourth Edition provides a practical and comprehensive overview of the daily issues facing pharmaceutical researchers and chemists. In addition to its thorough treatment of basic medicinal chemistry principles, this updated edition has been revised to provide new and expanded coverage of the latest technologies and approaches in drug discovery. With topics like high content screening, scoring, docking, binding free energy calculations, polypharmacology, QSAR, chemical collections and databases, and much more, this book is the go-to reference for all academic and pharmaceutical researchers who need a complete understanding of medicinal chemistry and its application to drug discovery and development. Includes updated and expanded material on systems biology, chemogenomics, computer-aided drug design, and other important recent advances in the field Incorporates extensive color figures, case studies, and practical examples to help users gain a further understanding of key concepts Provides high-quality content in a comprehensive manner, including contributions from international chapter authors to illustrate the global nature of medicinal chemistry and drug development research An image bank is available for instructors at www.textbooks.elsevier.com
Practical Medicinal Chemistry
Author | : Jayaveera K.N./ Subramanyam S. & Reddy, Yogananda K. |
Publsiher | : S. Chand Publishing |
Total Pages | : 135 |
Release | : 2024 |
Genre | : Medical |
ISBN | : 9788121942454 |
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Introduction 2. Synthesis Of Some Official Medicinal Compounds 3. Assay Of Some Official Compounds 4. Monograph Analysis Of The Following Compounds 5. Identification And Estimation Of Drug Metabolites From Biological Fluids 6. Determination Of Partition Coefficient Of Compounds For Qsar Analysis 7. I.R. Spectra Of Some Official Medicinal Compounds
Macrocycles in Drug Discovery
Author | : Jeremy I Levin |
Publsiher | : Royal Society of Chemistry |
Total Pages | : 526 |
Release | : 2015 |
Genre | : Medical |
ISBN | : 9781849737012 |
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This series provides a comprehensive resource for postgraduate students and for scientists in academia or industry wanting to learn topics outside their own areas of expertise.
The Practice of Medicinal Chemistry
Author | : Camille Georges Wermuth |
Publsiher | : Academic Press |
Total Pages | : 982 |
Release | : 2011-05-02 |
Genre | : Medical |
ISBN | : 9780080568775 |
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The Practice of Medicinal Chemistry fills a gap in the list of available medicinal chemistry literature. It is a single-volume source on the practical aspects of medicinal chemistry. Considered ""the Bible"" by medicinal chemists, the book emphasizes the methods that chemists use to conduct their research and design new drug entities. It serves as a practical handbook about the drug discovery process, from conception of the molecules to drug production. The first part of the book covers the background of the subject matter, which includes the definition and history of medicinal chemistry, the measurement of biological activities, and the main phases of drug activity. The second part of the book presents the road to discovering a new lead compound and creating a working hypothesis. The main parts of the book discuss the optimization of the lead compound in terms of potency, selectivity, and safety. The Practice of Medicinal Chemistry can be considered a ""first-read"" or ""bedside book"" for readers who are embarking on a career in medicinal chemistry. NEW TO THIS EDITION: * Focus on chemoinformatics and drug discovery * Enhanced pedagogical features* New chapters including: - Drug absorption and transport - Multi-target drugs* Updates on hot new areas: NEW! Drug discovery and the latest techniques NEW! How potential drugs can move through the drug discovery/ development phases more quickly NEW! Chemoinformatics
The Practice of Medicinal Chemistry
Author | : Camille Georges Wermuth |
Publsiher | : Elsevier |
Total Pages | : 736 |
Release | : 2003-06-11 |
Genre | : Science |
ISBN | : 9780080497778 |
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The Practice of Medicinal Chemistry, 2E, is a single-volume source on the practical aspects of medicinal chemistry. The successful first edition was nicknamed "The Bible" by medicinal chemists, and the second edition has been updated, expanded and refocused to reflect developments over the last decade. Emphasis is put on how medicinal chemists conduct their search for and design of new drug entities. In contrast to competing books, it focuses on the chemistry rather than pharmacological concepts or descriptions of the various therapeutic classes of drugs. Most medicinal chemists working in the pharmaceutical industry are organic synthetic chemists who must acquire a strong knowledge of medicinal chemistry as they enter the industry. This book aims to be their practical handbook - a complete guide to the drug discovery process. * The only book available dealing with the practical aspects of medicinal chemistry * Serves as a complete guide to the drug discovery process, from conception of the molecules to drug production * Updated chapters devoted to the discovery of new lead compounds, including combinatorial chemistry
Supramolecular Systems in Biomedical Fields
Author | : Hans-Jorg Schneider |
Publsiher | : Royal Society of Chemistry |
Total Pages | : 550 |
Release | : 2013-09-06 |
Genre | : Science |
ISBN | : 9781849737821 |
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Non-covalent interactions, which are the heart of supramolecular chemistry are also the basis of most important functions of living systems. The ability to apply supramolecular chemistry principles to the life sciences, such as designing synthetic host compounds to selectively interact within biological targets, has gained wide appeal due the vast number of potential applications. Supramolecular Systems for Biomedical Fields provides in sixteen chapters a comprehensive overview of these applications. Each chapter covers a specific topic and is written by internationally renowned experts in that area. Sensing of bioactive inorganic ions and organic substrates is the focus of several contributions, as well as interactions with proteins and nucleic acids. Specific chapters are devoted to cyclodextrins, calixarenes and cucurbiturils as most frequently used receptors, including applications such as drug delivery and protection, gene transfer and others. Other chapters address the use of combinatorial libraries, molecular imprinting techniques, enzyme assays, supramolecular gels, bioimaging, drug activation, photodynamic therapy, and antitumour metal complexes. This timely publication will appeal to graduate students and researchers from chemical, pharmaceutical, biological, and medicinal fields interested in the supramolecular chemistry of biological systems and their practical potentials.