Practical Pharmacology For Alzheimer S Disease

In this book, the four leading experts on the ACE inhibitors donepezil, galantamine, and rivastigmine and the NMDA receptor antagonist memantine explain the practical pharmacology of these symptomatic drugs with the aim of providing a sound basis for their clinical use in patients with Alzheimer’s disease. In addition, an introductory chapter considers the basic theory of pharmacology for Alzheimer’s disease and the book closes with an overview of the ways in which symptomatic drugs for dementia are used. The wide acceptance of the amyloid cascade hypothesis has led to vigorous development of disease-modifying drugs for Alzheimer’s disease, such as amyloid vaccinations and gamma- or beta-secretase inhibitors. The failure of clinical trials of these drugs to yield satisfactory results has, however, meant that for the time being patients continue to be treated only with symptomatic drugs. There is accordingly a need to become more proficient in the use of symptomatic medicines, and it is against the background of this quest that Practical Pharmacology for Alzheimer’s Disease will be of wide interest.

The wide acceptance of the amyloid cascade hypothesis has led to vigorous development of disease-modifying drugs for Alzheimer's disease, such as amyloid vaccinations and gamma- or beta-secretase inhibitors. However, the fact that clinical trials of these drugs have not yet yielded satisfactory results has meant that for the time being patients continue to be treated only with symptomatic drugs. Currently, four such drugs are available: donepezil, galantamine, rivastigmine, and memantine. In this book, the four leading experts on each of these drugs explain their practical pharmacology with the aim of providing a sound basis for their use, which to date has been of questionable proficiency. In addition, an introductory chapter considers the basic theory of pharmacology for Alzheimer's disease and the book closes with an overview of the ways in which symptomatic drugs are used for dementia.

Alzheimer’s disease (AD) is a devastating and dehumanizing illness affecting increasingly large numbers of elderly and even middle-aged persons in a worldwide epidemic. Alzheimer’s Disease: A Physician’s Guide to Practical Management was written by selected clinicians and scientists who represent some of the world’s leading centers of excellence in AD research. The editors are proud and grateful for their profound contributions. This book is particularly designed to assist physicians and other health-care professionals in the evaluation, assessment, and treatment of individuals with AD. At the same time, by illuminating the basic scientific background, we hope to provide state-of-the art information about the disease and possible future therapeutic strategies. The recent psychiatric treatment aspects of AD are also clearly presented. Because the early diagnosis of the dementia process is now considered of increasing importance, we focus particularly in several chapters on early changes and preclinical conditions, such as mild cognitive impairment and predementia AD.

Tailoring mental illness drug treatments specifically for elderly people has been a neglected area. This book brings together findings from recent multi-disciplinary research and the practical aspects of old age psychiatry. By taking into account the perspectives of the patient and their family, the neuropathologist, the pharmacist, the nurse, the GP, and the specialist, Practical Old Age Psychopharmacology provides a sympathetic analysis of contemporary practice and offers guidelines for the future. Providing the only comprehensive overview of the topic the editors delve into the important role of psychotropic drugs and the management of mental illness in the elderly, how these drugs should be used and how a truly personal approach to patient care can be maintained. To provide a practical focus on specific clinical topics, individual chapters can be used independently This book is an invaluable reference for old age psychiatrists, psychiatrists in training, hospital and community mental health nurses, geriatricians, general practitioners, and pharmaceutical company staff. Clinical psychologists, social workers, occupational therapists and health care managers will also find it beneficial as a complement to their own work.

Tailoring mental illness drug treatments specifically for elderly people has been a neglected area. This book brings together findings from recent multi-disciplinary research and the practical aspects of old age psychiatry. By taking into account the perspectives of the patient and their family, the neuropathologist, the pharmacist, the nurse, the GP, and the specialist, Practical Old Age Psychopharmacology provides a sympathetic analysis of contemporary practice and offers guidelines for the future. Providing the only comprehensive overview of the topic the editors delve into the important role of psychotropic drugs and the management of mental illness in the elderly, how these drugs should be used and how a truly personal approach to patient care can be maintained. To provide a practical focus on specific clinical topics, individual chapters can be used independently This book is an invaluable reference for old age psychiatrists, psychiatrists in training, hospital and community mental health nurses, geriatricians, general practitioners, and pharmaceutical company staff. Clinical psychologists, social workers, occupational therapists and health care managers will also find it beneficial as a complement to their own work.

Practical Pharmacology in Rehabilitation discusses the effects of medications in the rehabilitation process and assists rehabilitation professionals in designing patient-specific therapy plans based on coexisting disease states and medications used.

Global Clinical Trials for Alzheimer’s Disease is a handy one-stop reference for researchers and physicians planning and conducting global clinical trials in this area. This book addresses important considerations that may arise during the successful design and execution of these trials, including site selection, local regulatory issues, pharmacogenomics, ethical matters and much more. Given the saturation of traditional clinical trial markets and the worldwide progression of Alzheimer’s disease, there is a need to focus on clinical trials in emerging markets and developing countries. This book provides you with a practical approach to recognizing the opportunities and tackling the challenges that are present during the planning and execution of global clinical trials for Alzheimer’s disease. Written by leading experts with hands-on experience in designing and running global Alzheimer’s disease and other neurodegenerative diseases clinical trials A step-by-step guide that provides critical information on the design, conduct and standardization necessary to effectively execute clinical trials and accelerate drug development in this area Includes practical examples, ethical considerations, lessons learned and other valuable tools to aid the planning and implementation of Alzheimer’s disease global clinical trials in emerging markets and developing countries

Pharmacology in Nursing, Australian and New Zealand 3rd Edition focuses on the use of drugs as medications within the healthcare environment in Australia and New Zealand. This text is a resource for nurses and health professionals in their understanding of drugs and their actions, especially with regard to the responsibilities of nurses in relation to medication administration and patient management. The text introduces medications and medication therapies, and the principles and methods of medication administration, with an emphasis on the implications for nursing care. Specific medication therapy considerations for vulnerable groups are presented to highlight the special concerns for these groups. A review of dosage calculations is also included. The text takes a body systems approach, focusing on the pharmacology of the medications that act on the various body systems and their disorders.