Prostrate Cancer

In Canada, one man in seven risks developing prostate cancer. It is the most frequently diagnosed cancer in men and its incidence has increased by 30 percent since 1988. While most commonly diagnosed after age 70, prostate cancer can also occur in men in their forties and fifties. Like other forms of cancer, this disease affects not only the patient but also his family. At the time of diagnosis, there are many questions that need to be answered. This book provides a simple, concise, practical guide to help patients understand prostate cancer. Now in its third edition, it has, over the years, become an indispensable reference work. It is an outstanding source of information on the prevention and causes of prostate cancer, its early diagnosis and the treatment options available, including their side effects and complications.

Prostate Cancer, Science and Clinical Practice, Second Edition, continues to be an important translational reference that bridges the gap between science and clinical medicine. It reviews the biological processes that can be implicated in the disease, reviews current treatments, highlights the pitfalls where relevant, and examines the scientific developments that might result in future treatments. Key chapters from the previous edition have been updated, and a plethora of new chapters describe new concepts of prostate cancer biology and newly developed therapeutics. Each chapter has been written by internationally recognized specialists on prostate cancer epidemiology, genetic susceptibility, cancer metastases, prostate physiology, proteomics, new therapeutics, and clinical trials. Presents a comprehensive, translational source for all aspects of prostate cancer in one reference work Provides a common language for cancer researchers, oncologists, and urologists to discuss prostate tumors and how prostate cancer metastases affects other major organ systems Offers insights to research clinicians, giving them a key understanding the molecular basis of prostate cancer Offers insights to cancer researchers into how clinical observations and practices can feed back into the research cycle and, therefore, can contribute to the development of more targeted genomic and proteomic assays

This guide covers every aspect of prostate cancer, from potential causes including diet to tests for diagnosis, curative treatment, and innovative means of controlling advanced stages of cancer.

The purpose of this book is to provide a contemporary overview of the causes and consequences of prostate cancer from a cellular and genetic perspective. Written by experts in the fields of epidemiology, toxicology, cell biology, genetics, genomics, cell-cell interactions, cell signaling, hormone signaling, and transcriptional regulation, the text covers aspects of prostate cancer from disease initiation to metastasis. Chapters explore in depth the cells of origin for prostate cancer, its genomic subtypes, neural transcription factors in disease progression, epigenetic regulation of chromatin, and many other topics. This book distinguishes itself from other texts on prostate cancer by its focus on cellular and genetic mechanisms, as opposed to clinical diagnosis and management. As a result, this book will be of broad interest to basic and translational scientists with familiarity of these topics, as well as to trainees at earlier stages of their research careers.

This volume maintains the successful Current Multidisciplinary Oncology series format. Section I provides a review of fundamental issues including epidemiology, screening and risk reduction, diagnosis and pathologic characterization, staging, and imaging. There is also a chapter on counseling of the high-risk patient. Section II, Treatment of Localized Disease, provides a thorough review of the range of multidisciplinary management options for these patients including a discussion of quality of life impact. Section III, Treatment of Localized Advanced Disease, provides a detailed review of multimodal (medical, surgical, radiologic) therapies. Section IV, Treatment of Advanced Disease, reviews management courses for metastatic disease including the range of novel and experimental agents likely to have major impact on practice. Throughout the volume the emphasis is on multidisciplinary collaboration and decision-making in the management of the prostate cancer patient.

Prostate cancer is unusual among solid tumors in that the majority of affected men die with, rather than of, the disease. This presents many challenges to healthcare professionals and patients in terms of deciding if, when and how to intervene in order to control tumor growth and spread, thereby extending survival but without compromising quality of life. This is the ninth edition of 'Fast Facts: Prostate Cancer' since 1996, testament to the rapid changes in the field and the steadily improving outlook for patients. This new edition provides many key updates: • the Gleason grade grouping, which has valuable prognostic value • nomograms to evaluate risk • our rapidly expanding understanding of the genetics and underlying pathogenesis of prostate cancer and the development of genomic tests to help identify those at greatest risk of developing clinically significant disease • the continuing debate about the role of PSA in the screening, detection and monitoring of prostate cancer • advances in imaging techniques, particularly multiparametric MRI, which is improving the accuracy of biopsy and reducing the numbers of negative biopsies • the roles of drugs, surgery and radiotherapy in the treatment of prostate cancer at different stages, and our ever-improving understanding of when and how best to intervene, aided by improving understanding of the risk factors for disease progression. Primarily intended for primary care providers, specialist nurses, junior doctors and allied healthcare professionals, this highly readable resource provides a comprehensive overview of prostate cancer, enabling fully informed discussions with patients about this complex disease. Contents: • Epidemiology and pathophysiology • Diet, lifestyle and chemoprevention • Screening and early detection • Diagnosis, staging and prognostic indicators • Management of clinically localized disease • Managing recurrence after initial therapy • Management of metastatic prostate cancer • Management of castrate-resistant prostate cancer • Survivorship and treatment complications

Hearing that you have prostate cancer, or even that you may have it, is very scary. But this disease, in many cases, is curable. Even if you have advanced cancer that's spread beyond the prostate, many treatments help extend your life for years. You need good information to help you with the decisions that lie ahead, and this book provides you with this information. Prostate Cancer For Dummies can help you if You have prostate cancer (or you think that you have it), or someone close to you has it. You want information on treatments for prostate cancer as you form a treatment plan with your doctor. You are curious about alternative therapies for prostate cancer. You want to know what actions you can take over the long-term to continue to fight your prostate cancer. Prostate Cancer For Dummies explains the key issues and problems that are associated with prostate cancer, and assures you that although the initial impact of being diagnosed is devastating, you can take action to extend your life. You don't have to read this book from the first page straight on through, although you can. You may want to read the first chapter and then move to the chapters that affect you the most. In Prostate Cancer For Dummies, you'll gain insight into Discovering the key symptoms of prostate cancer Recognizing the risk factors, and who's most likely to have prostate cancer Getting a diagnosis, and what's involved Getting well again, and how you can work with your doctor to come up with a plan to cope with your cancer Changing your lifestyle to decrease your risk of a recurrence Coping with the aftermath, from temporary to permanent side effects Handling work and family, and how to help others understand what you're going through It's extremely hard to hear from your doctor that you or a loved one has prostate cancer. But after you recover from the initial shock of diagnosis, you need to educate yourself, and, with the help of your physician, make a plan for getting the best treatment possible. Prostate Cancer For Dummies will help you achieve these goals and encourage you to maintain your commitment to managing your health.

Prostate cancer is the commonest male cancer with over 5 million survivors in US alone. Worldwide, the problem is staggering and has attracted significant attention by media, scientists and cancer experts. Significant research, discoveries, innovations and advances in treatment of this cancer have produced voluminous literature which is difficult to synthesize and assimilate by the medical community. Prostate Cancer: A Comprehensive Perspective is a comprehensive and definitive source which neatly resolves this problem. It covers relevant literature by leading experts in basic science, molecular biology, epidemiology, cancer prevention, cellular imaging, staging, treatment, targeted therapeutics and innovative technologies. Prostate Cancer: A Comprehensive Perspective, is a valuable and timely resource for urologists and oncologists.