Protein And Peptide Nanoparticles For Drug Delivery

Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology series has been the essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics. Describes advances in application of powerful techniques in a wide bioscience area Chapters are written by authorities in their field Targeted to a wide audience of researchers, specialists, and students The information provided in the volume is well supported by a number of high quality illustrations, figures, and tables

The growing area of peptide and protein therapeutics research is of paramount importance to medical application and advancement. A needed reference for entry level researchers and researchers working in interdisciplinary / collaborative projects, Peptide and Protein Delivery addresses the current and emerging routes for delivery of therapeutics. Covering cerebral delivery, pulmonary delivery, transdermal delivery, intestinal delivery, ocular delivery, parenteral delivery, and nasal delivery, this resource offers an overview of the main routes in therapeutics. Researchers across biochemistry, pharmaceutical, molecular biology, cell biology, immunology, chemistry and biotechnology fields will find this publication invaluable for peptide and protein laboratory research. Discusses the most recent data, ideas and concepts Presents case studies and an industrial perspective Details information from the molecular level to bioprocessing Thought provoking, for the novice to the specialist Timely, for today's biopharmaceuticals market

This important new book provides the fundamental understanding of the peptide and protein drug delivery systems with a special focus on their nanotechnology applications. Addressing an increasing interest in peptide and protein drug delivery systems in both academic and industrial circles worldwide, this book fills the need for a comprehensive review and assessment of conventional and nonconventional routes of administration.

In response to the tremendous increase in the number of protein and peptide drugs, this treatise critically reviews transport and metabolism mechanisms relating to the delivery of endogenous and recombinant proteins to mammalian organs, tissues, and cells. It will promote fruitful collaboration among academic and industrial scientists in the fields of pharmacology, cell biology, biochemistry, physiology, and immunology.

First published in 1995. Routledge is an imprint of Taylor & Francis, an informa company.

In this concise and systematic book, a team of experts select the most important, cutting-edge technologies used in drug delivery systems. They take into account significant drugs, new technologies such as nanoparticles, and therapeutic applications. The chapters present step-by-step laboratory protocols following the highly successful Methods in Molecular BiologyTM series format, offering readily reproducible results vital for pharmaceutical physicians and scientists.

Written by leading scientists in the field of delivery of protein and peptide drugs to tumors for cancer therapy, this important book provides a broad introduction to the field, with discussion by key experts on the physiological barriers for protein and peptide drugs in tumors, and the different approaches to stabilization of these drugs in biological surroundings, as well as their enhanced delivery to tumors and inside cancer cells. This book can be used as an advanced textbook by graduate students and young scientists and clinicians at the early stages of their career. It is also suitable for non-experts from related areas of chemistry, biochemistry, molecular biology, physiology, experimental and clinical oncology and pharmaceutical sciences, who are interested in general problems of drug delivery and drug targeting as well as in a more specialized topics of using protein and peptide drugs for tumor therapy. Prof Torchilin is an expert in Nanomedicine and a recipient of numerous awards including the Lenin Prize in Science & Technology of the former USSR, membership in the European Academy of Sciences, and AAPS Research Achievement Award in Pharmaceutics and Drug Delivery. He served as an Associate Professor of Radiology at Harvard Medical School before joining Northeastern University as the Chairman of the Department of Pharmaceutical Sciences. Contents:Influence of Tumor Physiology on Delivery of Therapeutics (R B Campbell)Enhanced Permeability and Retention (EPR) Effect and Tumor-Selective Delivery of Anticancer Drugs (K Greish et al.)Basic Strategies for PEGylation of Peptide and Protein Drugs (G Pasut et al.)PEGylated Proteins as Cancer Therapeutics (M Morpurgo et al.)PEGylated Proteins in Immunotherapy of Cancer (J F Eliason)Silencing Proteins: Nanotechnological Approaches to Deliver of siRNA for Cancer Therapy (R M Schiffelers et al.)Anti-Cancer Proteins and Peptides in Liposomes (V Torchilin)Folate-Mediated Delivery of Protein and Peptide Drugs into Tumors (J A Reddy et al.)Transferrin Receptor Mediated Delivery of Protein and Peptide Drugs into Tumors (J Fahrmeir & M Ogris)Transmembrane Delivery of Protein and Peptide Drugs into Cancer Cells (C C Saenz & S F Dowdy)Protein and Peptide Drugs to Suppress Tumor Angiogenesis (C Rüegg)Utilizing Lymphatic Transport in Enhancing the Delivery of Drugs, Including Proteins, and Peptides, to Metastatic Tumors (E K Wasan & K M Wasan)Delivery of Protein and Peptide Drugs to Brain Tumors (H B Newton)Protein and Peptide-Based Cancer Gene Therapy (S Chada & R Ramesh) Readership: Graduate students & academics from cancer therapy, protein & peptide drugs, drug delivery, & tumor targeting areas; non-experts interested in drug delivery to tumors. Key Features:Written by leading scientists such as Prof Veronese, Prof Maeda, Prof Dowdy, Prof Torchilin & Prof WasanDetailed explanation of physiological barriers for protein and peptide drugs in tumorsDifferent approaches to the stabilization of proteins and peptides in biological surroundings and their enhanced delivery into tumors and inside cancer cellsKeywords:Cancer;Protein & Peptide Drugs;Delivery;Tumor Physiology;Drug Carriers;Pegylation;Liposomes;Angiogenesis;Lymphatic Transport;Protein Transduction

Peptide and Protein Drug Delivery Using Polysaccharides offers an interdisciplinary discussion of polysaccharides applied in peptide and protein drug delivery. Chapters consider basic biology of different polysaccharides of current interest and their production at pilot and large-scale stages by various techniques including, but not limited to, cell and hairy root cultures. Other sections examine factors affecting polysaccharide absorption, metabolism, and excretion in nascent, encapsulated, or conjugated forms, with unique coverage of vaccine absorption, metabolism, and drug delivery. A final section considers analytical methods for detection in tissue fluids and homogenates. Accessible figures, tables, and graphical abstracts are included throughout to support understanding. Specific polysaccharides discussed for therapeutic purposes include cellulose, hyaluronic acid, heparin, carageenan, alginic acid, agar and myrrh, acacia, tragacanth, ghatti gum, chitin, chitosan, starch, glycogen and dextran. Adopts an interdisciplinary approach across biochemistry, molecular biology, pharmaceutical sciences and drug delivery, and biotechnological perspectives Features accessible figures, tables and graphical abstracts across all chapters to support understanding Examines various polysaccharides of current interest and aspects affecting their absorption, metabolism, excretion and detection