Q Fever

Biosecurity and Bioterrorism, Second Edition, takes a holistic approach to biosecurity, with coverage of pathogens, prevention, and response methodology. It addresses these hazards in the context of vulnerability assessments and the planning strategies government and industry can use to prepare for and respond to such events. The book is organized into four thematic sections: Part I provides a conceptual understanding of biowarfare, bioterrorism and the laws we have to counteract this; Part II investigates known bioagents and the threat from emerging diseases; Part III focuses on agricultural terrorism and food security; and Part IV outlines international, US, and local initiatives for biodefense and biosecurity. Case studies illustrate biodefense against both intentional terrorism and natural outbreaks. Covers emerging threats of pandemic influenza, antibiotic resistant strains of bacterial pathogens, and severe respiratory diseases caused by novel viruses Offers increased international coverage, including initiatives to counter biological weapons and threats, and food security Updated throughout with latest protocols for dealing with biological threats and new case studies Includes online instructor ancillaries - PowerPoint lecture slides, test questions, and an instructor manual, for increased classroom functionality

This essential, authoritative handbook provides clear, accurate coverage of zoonoses — diseases that can spread from animals to humans. The consistent format helps you quickly locate key information, such as how each disease affects the host, how it is spread, how it is treated, and necessary safety precautions. It also discusses the importance of educating animal owners about the public health implications of zoonoses and how to prevent them from spreading. Clear, concise coverage helps you respond quickly when presented with diseases that could potentially spread between patients, clients, and staff in the veterinary clinic. Each disease entry begins with a chart of its potential morbidity (the rate of incidence of a disease) and mortality (death rate), giving you at-a-glance access to the chance of contracting the disease and the severity of the disease if contracted. Clinically relevant coverage includes information on the etiology (bacterial, viral, parasitic, etc.), most common nonhuman hosts, transmission modes, course of the disease, clinical signs in animals and humans, diagnostic tests, prevention, and general advice. Essential information on preventing the spread of disease helps you educate clients about how to protect themselves and their animals from zoonoses. Coverage of diseases such as mad cow disease, West Nile virus, rabies, and anthrax, prepares you to answer client questions about diseases that are in the public eye.

The only available reference to comprehensively discuss the common and unusual types of rickettsiosis in over twenty years, this book will offer the reader a full review on the bacteriology, transmission, and pathophysiology of these conditions. Written from experts in the field from Europe, USA, Africa, and Asia, specialists analyze specific patho

Q fever is a zoonotic infectious disease caused by Coxiella burnetii, which infects a broad range of hosts. This volume presents critical reviews of the biological aspects of C. burnetii. Topics covered include C. burnetii's place in the microbial world through a comparison with other microorganisms that are phylogenetically related or share phenotypic traits; intrinsic properties of Coxiella with respect to infectivity, virulence, and pathogenecity; past and current methods for the isolation, amplification, and purification of C. Burnetii; obligate acidophily; metabolic capabilities, with emphasis on intermediary metabolism, macromolecular synthesis, and protein export; and human immune responses to bacterial components during acute and chronic infection by C. Burnetii. Other fascinating topics about C. Burnetii include antigens, virulence factors, and biological response modifiers; ultrastructure; genetics; cloning and expression; and C. burnetii in the U.S.S.R. and China. Epidemiologists, molecular biologists, microbiologists, and other researchers interested in Q fever and C. burnetii should consider this book an essential reference resource.

NORD Guide to Rare Disorders is a comprehensive, practical, authoritative guide to the diagnosis and management of more than 800 rare diseases. The diseases are discussed in a uniform, easy-to-follow format--a brief description, signs and symptoms, etiology, related disorders, epidemiology, standard treatment, investigational treatment, resources, and references.The book includes a complete directory of orphan drugs, a full-color atlas of visual diagnostic signs, and a Master Resource List of support groups and helpful organizations. An index of symptoms and key words offers physicians valuable assistance in finding the information they need quickly.

The purpose of this book is to bring together, in a single volume, the most up-to-date information concerning microbes with potential as bioterrorist weapons. The primary audience includes microbiologists, including bacteriologists, virologists and mycologists, in academia, government laboratories and research institutes at the forefront of studies concerning microbes which have potential as bioterrorist weapons, public health physicians and researchers and scientists who must be trained to deal with bioterrorist attacks as well as laboratory investigators who must identify and characterize these microorganisms from the environment and from possibly infected patients.

Coxiella burnetii is the etiological agent of Q fever, a zoonotic disease found worldwide. The bacterium is a fascinating example of intracellular parasitism that has uniquely evolved to thrive in the most inhospitable of cellular compartments-the phagolysosome. Understanding how C. burnetii resists the degradative functions of this vacuole, and the host cell functions coopted for successful parasitism, are central to understanding Q fever pathogenesis. Recent achievements in glycomics and proteomics are guiding development of enhanced detection schemes for the bacterium in addition to shedding light on the host immune response to the pathogen. Several chapters survey immune functions that control or potentially exacerbate Coxiella infection and delve into correlates of protective immunity elicited by vaccination. Comparative genomics is also the foundation of chapters discussing diagnostic antigen discovery and molecular typing of the bacterium, with significance for development of new clinical, epidemiologic, and forensic tools.

This fascinating book describes the history, and epidemiology in both man and animals, and clinical features of this zoonosis. It reveals detailed information pertaining to the basic science aspects of the interaction of Coxiella burnetii, the etiologic agent of Q (Query) fever, with the host and the immune response of the host to this unique pathogen. This one-of-a-kind work uses the rules of epidemiological evidence to determine whether or not Coxiella burnetii is a perinatal pathogen for man. This interesting, easy-to-understand text concludes with chapters dealing with the antibiotic susceptibility of Coxiella burnetii and the studies that resulted in a vaccine that now can be used to prevent this infection. This volume is an absolute must for all microbiologists, respirologists, infectious disease physicians and veterinarians.