Quantitative Functional Brain Imaging With Positron Emission Tomography

This book presents the latest scientific developments in the field of positron emission tomography (PET) dealing with data acquisition, image processing, applications, statistical analysis, tracer development, parameter estimation, and kinetic modeling. It covers improved methodology and the application of existing techniques to new areas. The text also describes new approaches in scanner design and image processing, and the latest techniques for modeling and statistical analyses. This volume will be a useful reference for the active brain PET scientist, as well as a valuable introduction for students and researchers who wish to take advantage of the capabilities of PET to study the normal and diseased brain. Authored by international authorities in PET Provides the latest up-to-date techniques and applications Covers all fundamental disciplines of PET in one volume A comprehensive resource for students, clinicians, and new PET researchers

Functional imaging of the brain is one of the most rapidly advancing areas of neuroscience and Positron Emission Tomography (PET) plays a major role in this progress. This book provides a comprehensive overview of the current status of PET and state-of-the-art neuroimaging. It is comprised of summaries of the presentations by experts in the field. Topics covered include radiotracer selection, advances in instrumentation, image reconstruction and data analysis, and statistical mapping of brain activity. This book focuses on the accuracy of the functional image and the strategies for addressing clinical, scientific, and diagnostic questions. Covers the PET imaging process from tracer selection to analysis and interpretation Contains 79 concise reports with abundant illustrations The definitive state-of-the-art book for functional neuroscience with PET

Physiological Imaging of the Brain with PET provides the latest techniques and applications for PET as a tool to study the physiology of the brain, and is sponsored by the International Society of Cerebral Blood Flow and Metabolism. It covers all of the fundamental disciplines of PET in one volume. Written by international experts in brain imaging, it is a useful reference for the active brain PET scientist, and a valuable introduction to students, clinicians, and researchers who wish to take advantage of the capabilities of this technique to study the normal and diseased brain. Key Features * Provides the latest techniques and applications of positron emission tomography (PET) * Covers all fundamental disciplines of PET in one volume * Serves as a comprehensive resource for students, clinicians and new researchers

This volume highlights the remarkable new developments in brain imaging, including those that apply magnetic resonance imaging (MRI) and Positron Emission Tomography (PET), that allow us to non invasively study the living human brain in health and in disease. These technological advances have allowed us to obtain new and powerful insights into the structure and function of the healthy brain as it develops across the life cycle, as well as the molecular make up of brain systems and circuits as they develop and change with age. New brain imaging technologies have also given us new insights into the causes of many common brain disorders, including ADHD, schizophrenia, depression and Alzheimer’s disease, which collectively affect a large segment of the population. These new insights have major implications for understanding and treating these brain disorders, and are providing clinicians with the first ever set of biomarkers that can be used to guide diagnosis and monitor treatment effects. The advances in brain imaging over the last 20 years, summarized in this volume, represent a major advance in modern biomedical sciences.

Functional Brain Imaging

This is a unique and richly illustrated book that concisely explains topographic mapping of electrical and magnetic brain activity, and relates this technique to metabolic and regional blood flow studies. Also addressed are important results of experimental and clinical investigations, as well as problems of electrical magnetic data and topographic display.

This volume covers the latest developments in optical imaging of the brain which is becoming an increasingly important functional neuroimaging method. Optical intrinsic signals offer unrivaled temporal and spatial resolution of functional measurements of the exposed brain cortex in animals and humans. Near-infrared spectroscopy and imaging ap proaches permit the noninvasive functional assessment of the human brain at bedside. Main advantages of these optical techniques are the biochemical specificity of the meas urements and the potential of measuring correlates of intracellular and intravascular oxy genation simultaneously. Recent data indicate that one may also measure a more direct correlate of neuronal activity associated with changes in light scattering. In this volume, recent technical progress of the optical method is covered as well as the physiological basis of the measurements. In simultaneous studies, near-infrared spec troscopy measurements are directly compared to other functional methods, especially PET and fMRI and examples are given for new applications of the NIRS-method. Based on re sults obtained with optical methods and other functional techniques the latest in our under standing of the coupling of neuronal activity and cerebral blood flow response is reviewed. This is an important basis for a better understanding of all functional neuroi maging methods which rely on neurovascular coupling such as PET, SPET and fMRI. Fi nally the optical method is put into the perspective of presently available functional neuroimaging methods including fMRI, PET, MEG and EEG.

Details the application of positron emission tomography (PET) to the mapping of human cerebral cortical function. Coverage includes all aspects of PET technology. Includes chapters on somatosensory, motor and visual systems, and higher-order processes such as attention, memory, learning, intention and language. The clinical usefulness of PET is discussed in relation to psychiatric illness and to functional recovery after brain injury.