Recent Progress In Mitral Valve Disease

Recent Progress in Mitral Valve Disease presents a comprehensive examination of the proceedings that resulted from the International Symposium that transpired in Paris. It discusses the anatomy and physiology of the mitral valve. It addresses the cyclical motion of the mitral valve leaflets. Some of the topics covered in the book are the cyclical motion of the mitral annulus; analysis of hypertrophic cardiomyopathy; diagnoses of acute myocardial ischemia; characteristics of an abnormally functioning, structurally abnormal mitral valve; atrial function in normal cardiac cycle; and atrial function in acute mitral regurgitation. The factors that modify regurgitant volume are fully covered. An in-depth account of the methods for animal preparation and dynamics of acute experimental mitral regurgitation are provided. The uses and limitations of echocardiography in the examination of the mitral valve are completely presented. A chapter is devoted to the timing of surgical intervention in chronic mitral regurgitation. Another section focuses on the status of prosthetic valves in the mitral position. The book can provide useful information to doctors, cardiologists, students, and researchers.

Challenges for the treatment of valvular heart disease include the growing need for effective yet less invasive interventions and therapies to treat these progressive conditions. With the development of potential new treatments, it is crucial for cardiac physicians to be well informed on the pathophysiology, assessment, treatment options and their outcomes of valvular diseases. Written by a highly experienced and internationally recognized group of cardiologists, cardiac surgeons, and researchers, Valvular Heart Disease offers insights into the widely varying hemodynamic effects and clinical course of heart valve conditions, as well as the contemporary management of these conditions. Offering a broad perspective on these diseases, Valvular Heart Disease expands on the recent guidelines developed by the major heart societies in the United State and Europe.

This issue of Heart Failure Clinics, edited by Drs. Ragavendra R. Baliga and Umesh C. Samal, will focus on Recent Advances in Management of Heart Failure. Topics include, but are not limited to, Neprilysin Inhibition on Systolic HF, If Channel Inhibitor Ivabradine in Heart Failure, Growth Hormone Therapy in Heart Failure, Ultrafiltration in Heart Failure, Aldosterone Receptor Blockade in Diastolic HF, Intravenous Iron Therapy in HF, Management of Secondary Pulmonary Hypertension, Management of Chemotherapy Induced Cardiomyopathy, Management of HF in Adult Congenital Heart Disease, LVADS in Heart Failure, Short Term Circulatory & Right Ventricle support in Cardiogenic Shock, Mitral Valve Repair in HF, Total Artificial Heart, Current Status of Inotropes in Heart Failure, Palliative Therapy in Heart Failure, Subcutaneous ICDs and Leadless Pacemakers, Interventional Heart Failure and Hemodynamic Monitoring, and Management of Sleep Apnea in Heart Failure.

The notion that drugs can induce valvular heart disease (VHD) has occurred since the sixties and has received a lot of attention in recent years. Overstimulation of the serotonin 2B receptor (5-HT2B) leads to valvular fibroblast proliferation and thickening of the valvular leaflets with reduced mobility and regurgitation as a consequence. This new book focuses on different aspects of this distinct kind of valvulopathy including pathophysiology of drug-induced VHD, histopathological and echocardiographic characteristics, drugs associated with VHD, the influence of cumulative drug dose and risk factors and others.

Aneurysms-Osteoarthritis Syndrome: SMAD3 Gene Mutations is a first-of-its-kind compilation of the genetic discovery, research, and care associated with AOS. With the field of genetically triggered aortopathies growing, this important reference will compile the newest discoveries in this field, allowing cardiologists, cardio-thoracic surgeons, clinical geneticists, vascular surgeons, orthopedic surgeons, and researchers to gain the knowledge they need without having to gather the data from various sources. Coverage includes genotype and phenotype correlations, the functional role of SMAD3, and insights into the role of TGFbeta signaling in aortic disease. The book will increase knowledge about AOS, providing awareness and better patient care for this aggressive disease. Covers Aneurysms-Osteoarthritis Syndrome, from genetic discovery to patient care Contains clinical management guidance on optimal cardiovascular treatments and surgery Explains the autosomal dominant syndromes caused by mutations in the SMAD3 gene Identifies the key features of this syndrome, including arterial aneurysms and tortuosity, early onset arthritis, and mild craniofacial features

One of the most time-consuming tasks in clinical medicine is seeking the opinions of specialist colleagues. There is a pressure not only to make referrals appropriate but also to summarize the case in the language of the specialist. This book explains basic physiologic and pathophysiologic mechanisms of cardiovascular disease in a straightforward manner, gives guidelines as to when referral is appropriate, and, uniquely, explains what the specialist is likely to do. It is ideal for any hospital doctor, generalist, or even senior medical student who may need a cardiology opinion, or for that ma.

This volume focuses on the etiology and morphogenesis of congenital heart diseases. It reviews in detail the early development and differentiation of the heart, and later morphologic events of the cardiovascular system, covering a wide range of topics such as gene functions, growth factors, transcription factors and cellular interactions that are implicated in cardiac morphogenesis and congenital heart disease. This book also presents recent advances in stem cell and cell sheet tissue engineering technologies which have the potential to provide novel in vitro disease models and to generate regenerative paradigms for cardiac repair and regeneration. This is the ideal resource for physician scientists and investigators looking for updates on recent investigations on the origins of congenital heart disease and potential future therapies.

Acute Rheumatic Fever and Rheumatic Heart Disease is a concise, yet comprehensive, clinical resource highlighting must-know information on rheumatic heart disease and acute rheumatic fever from a global perspective. Covering the major issues dominating the field, this practical resource presents sufficient detail for a deep and thorough understanding of the latest treatment options, potential complications, and disease management strategies to improve patient outcomes. Divided into four distinct sections for ease of navigation: Acute Rheumatic Fever, Rheumatic Heart Disease, Population-Based Strategies for Disease Control, and Acute and Emergency Presentations. International editors and chapter authors ensure a truly global perspective. Covers all clinical aspects, including epidemiology, pathophysiology, clinical features, diagnosis, management, and treatment. Includes key topics on population-based measures for disease control for effective primary, secondary, and tertiary prevention. Consolidates today’s available information and guidance into a single, convenient resource.