Receptor Tyrosine Kinase Specificity In Mediating Migration And Induction Of Matrix Metalloprotease Mmp 9 In Keratinocyte And Squamous Cell Carcinoma

Cellular migration is an integral component of normal physiological processes including embryogenesis, angiogenesis, and wound healing. Aberrations in existing mechanisms which dictate epithelial migration can lead to pathological conditions such as tumor metastasis. Receptor tyrosine kinases regulate a many of the cellular events necessary in the development of a migratory phenotype including cell junction dissolution, cell locomotion and matrix remodeling; however, the functional consequences of receptor tyrosine kinase activation display receptor type and cell type specificity. The work described in this thesis addresses selectivity of receptor tyrosine action at several crucial stages required for cell motility and invasion. My research supports a role for selective induction of matrix metalloprotease (MMP)-9 by motogenic receptor tyrosine kinases, and demonstrates that activity of this protease is required during the course of keratinocyte migration, in addition, these studies suggest that duration of MAPK activation is a basis of discrimination between the motogenic and non-motogenic actions of various receptor tyrosine kinases. In this manner, prolonged activation of signaling components provides a mechanism to modulate gene products, such as MMP-9, required during migration, and thus represents an underlying biochemical mechanism for receptor tyrosine kinase specificity in the generation of a migratory phenotype.

Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.

By detailing experimental and basic research, from premalignancy to fully invasive tumors, this book has wide applicability to all human carcinomas. No other group of human cancers is better positioned for the application of recently developed novel and targeted therapies, and this book uniquely presents the unusual opportunities tumors of the head and neck provide for clinical, translational, and basic science research. Cutting-edge and experimental treatment approaches are presented, along with future strategies and an evaluation of emerging technologies. Presents a multi-disciplinary perspective from authorities in diverse fields Addresses state-of-the art approaches in cancer research as well as other scientific opportunities in this field Provides comprehensive yet easily comprehendible source of information

The merging of different basic and clinical science disciplines towards the common goal of fighting against cancer has long ago called for the establishment of a comprehensive reference source both as a tool to close the language gap between clinical and basic science investigators and as a platform of information for students and informed laymen alike. The Encyclopedia of Cancer provides rapid access to focused information on all topics of cancer research for clinicians, research scientists and advanced students. Given the overwhelming success of the Second Edition, which appeared in 2009, and fast recent development in the different fields of cancer research, it has been decided to publish a third fully revised and expanded edition, following the principal concept of the first edition that has proven so successful. Recent developments are seeing a dynamic progress in basic and clinical cancer science, with translational research increasingly becoming a new paradigm in cancer research. In particular, new approaches to both Personalized Cancer Medicine and Targeted Therapies have made promising progress. While the Second Edition featured scholarly contributions from approximately 1.000 scientists/clinicians in four Volumes, the Third Edition includes 1.300 contributors in 7 Volumes with an A-Z format of approx. 7000 entries. It provides definitions of common acronyms and short definitions of related terms and processes in the form of keyword entries. In addition, there are detailed essays, which provide comprehensive information on syndromes, genes and molecules, and processes and methods. Each essay is well-structured, with extensive cross-referencing between all entries. In the Third Edition, topical Essays present a comprehensive picture of major cancers, such as Breast Cancer, Colorectal Cancer, Prostate Cancer, Ovarian Cancer, Renal Cancer, Lung Cancer, and Hematological Maligancies, Leukemias and Lymphomas. For each of these cancers, different authoritative Essays are included that cover topics ranging from Pathology, to Clinical Oncology and Targeted Therapies. This new feature should meet the expectance that a wide community has towards a major cancer reference works. The Encyclopedia of Cancer will be accessible both in print and online, and this information source should be of value to both the clinical and basic scientific community as well as to the public.