Reflections On 25 Years Of Analysis Diagnosis And Prediction

The author describes the methods underlying short-term climate prediction at time scales of two weeks to a year. With an emphasis on the empirical approach, this text covers empirical wave propagation, teleconnections, empirical orthogonal functions, and constructed analogue.

A NEW YORKER BEST BOOK OF THE YEAR • A revolutionary new history that reveals how climate change has dramatically shaped the development—and demise—of civilizations across time *The ebook edition now includes endnotes. Anyone who purchased the book previously can re-download this updated edition and access the notes.* Global warming is one of the greatest dangers mankind faces today. Even as temperatures increase, sea levels rise, and natural disasters escalate, our current environmental crisis feels difficult to predict and understand. But climate change and its effects on us are not new. In a bold narrative that spans centuries and continents, Peter Frankopan argues that nature has always played a fundamental role in the writing of history. From the fall of the Moche civilization in South America that came about because of the cyclical pressures of El Niño to volcanic eruptions in Iceland that affected Egypt and helped bring the Ottoman empire to its knees, climate change and its influences have always been with us. Frankopan explains how the Vikings emerged thanks to catastrophic crop failure, why the roots of regime change in eleventh-century Baghdad lay in the collapse of cotton prices resulting from unusual climate patterns, and why the western expansion of the frontiers in North America was directly affected by solar flare activity in the eighteenth century. Again and again, Frankopan shows that when past empires have failed to act sustainably, they have been met with catastrophe. Blending brilliant historical writing and cutting-edge scientific research, The Earth Transformed will radically reframe the way we look at the world and our future.

Comprehensive and up-to-date information on Earth’s most dominant year-to-year climate variation The El Niño Southern Oscillation (ENSO) in the Pacific Ocean has major worldwide social and economic consequences through its global scale effects on atmospheric and oceanic circulation, marine and terrestrial ecosystems, and other natural systems. Ongoing climate change is projected to significantly alter ENSO's dynamics and impacts. El Niño Southern Oscillation in a Changing Climate presents the latest theories, models, and observations, and explores the challenges of forecasting ENSO as the climate continues to change. Volume highlights include: Historical background on ENSO and its societal consequences Review of key El Niño (ENSO warm phase) and La Niña (ENSO cold phase) characteristics Mathematical description of the underlying physical processes that generate ENSO variations Conceptual framework for understanding ENSO changes on decadal and longer time scales, including the response to greenhouse gas forcing ENSO impacts on extreme ocean, weather, and climate events, including tropical cyclones, and how ENSO affects fisheries and the global carbon cycle Advances in modeling, paleo-reconstructions, and operational climate forecasting Future projections of ENSO and its impacts Factors influencing ENSO events, such as inter-basin climate interactions and volcanic eruptions The American Geophysical Union promotes discovery in Earth and space science for the benefit of humanity. Its publications disseminate scientific knowledge and provide resources for researchers, students, and professionals. Find out more about this book from this Q&A with the editors.

In the last couple of decades, the study of the cancer genome and the progressive implementation of next-generation sequencing platforms have provided the Scientific and Oncology communities with a multitude of data, technologies, diagnostic, prognostic, and predictive tools that have been revolutionizing the way we can study, diagnose and treat cancer, including breast tumors. For example, genomic tests can now refine the prognosis of early-stage breast cancer patients beyond standard clinicopathological features and help guide escalated or de-escalated treatment choices. The identification of the molecular intrinsic subtypes might also be helpful in guiding treatment choices in advanced hormone receptor-positive disease. The identification of germline mutations in BRCA1 or BRCA2 has led to the development and introduction of PARP inhibitors for the treatment of advanced and early-stage breast cancer, along with personalized follow-up and prophylactic surgical procedures for patients with or without cancer, carrying such mutations.