Rise And Fall Of Epithelial Phenotype
Download Rise And Fall Of Epithelial Phenotype full books in PDF, epub, and Kindle. Read online free Rise And Fall Of Epithelial Phenotype ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Rise and Fall of Epithelial Phenotype
Author | : Pierre Savagner |
Publsiher | : Springer Science & Business Media |
Total Pages | : 341 |
Release | : 2007-07-05 |
Genre | : Science |
ISBN | : 9780387286716 |
Download Rise and Fall of Epithelial Phenotype Book in PDF, Epub and Kindle
Epithelial phenotype is a dynamic stage of differentiation that can be modulated during several physiological or pathological events. The rapid conversion to a mesenchymal-like phenotype is called an epithelial-mesenchymal transition (EMT). The Rise and Fall of Epithelial Phenotype is the first book to comprehensively introduce the concept of EMT. The first part of this volume describes main examples and models and explains their physiological relevance. These examples include hydra morphogenesis, gastrulation in mouse, drosophila and sea urchin, as well as neural crest cell migration and heart morphogenesis in vertebrates. Part two reviews in detail, specific EMT molecular pathways covering extracellular induction, transduction and transcription response and modulation of cell-cell adhesion structures. It emphasizes new specific pathways with potential medical applications. EMTs can also be linked to pathological events such as wound healing and cancer progression, as detailed in this section of the book.
Epithelial Mesenchymal Plasticity in Cancer Metastasis
Author | : Mohit Kumar Jolly ,Toni Celia-Terrassa |
Publsiher | : MDPI |
Total Pages | : 512 |
Release | : 2020-12-29 |
Genre | : Medical |
ISBN | : 9783039367245 |
Download Epithelial Mesenchymal Plasticity in Cancer Metastasis Book in PDF, Epub and Kindle
Recent studies have highlighted that epithelial-mesenchymal transition (EMT) is not only about cell migration and invasion, but it can also govern many other important elements such as immunosuppression, metabolic reprogramming, senescence-associated secretory phenotype (SASP), stem cell properties, therapy resistance, and tumor microenvironment interactions. With the on-going debate about the requirement of EMT for cancer metastasis, an emerging focus on intermediate states of EMT and its reverse process mesenchymal-epithelial transition (MET) offer new ideas for metastatic requirements and the dynamics of EMT/MET during the entire metastatic cascade. Therefore, we would like to initiate discussions on viewing EMT and its downstream signaling networks as a fulcrum of cellular plasticity, and a facilitator of the adaptive responses of cancer cells to distant organ microenvironments and various therapeutic assaults. We hereby invite scientists who have prominently contributed to this field, and whose valuable insights have led to the appreciation of epithelial-mesenchymal plasticity as a more comprehensive mediator of the adaptive response of cancer cells, with huge implications in metastasis, drug resistance, tumor relapse, and patient survival.
The Epithelial to Mesenchymal Transition EMT in Cancer
Author | : Joëlle Roche |
Publsiher | : MDPI |
Total Pages | : 261 |
Release | : 2018-04-09 |
Genre | : Electronic book |
ISBN | : 9783038427933 |
Download The Epithelial to Mesenchymal Transition EMT in Cancer Book in PDF, Epub and Kindle
This book is a printed edition of the Special Issue "The Epithelial-to-Mesenchymal Transition (EMT) in Cancer" that was published in Cancers
Ovarian Cancer
Author | : M. Sharon Stack,David A. Fishman |
Publsiher | : Springer Science & Business Media |
Total Pages | : 411 |
Release | : 2009-09-18 |
Genre | : Medical |
ISBN | : 9780387980942 |
Download Ovarian Cancer Book in PDF, Epub and Kindle
Ovarian carcinoma continues to be responsible for more deaths than all other gynecologic malignancies combined, due to a continued inability to achieve detection of early (rather than advanced) stage disease and the lack of effective tumor-specific therapeutics. Ovarian carcinogenesis, invasion, and metastatic dissemination require a complex cascade of interrelated genetic, molecular, and biochemical events that regulate the neoplastic transition of normal ovarian surface epithelium. This updated second edition includes exciting new advances in ovarian cancer detection and treatment and provides an analysis of current research into aspects of malignant transformation, growth control, and metastasis. A more detailed understanding of these processes may ultimately translate into the development of novel approaches for the detection and control of ovarian cancer.
Comparative Oncology
Author | : Alecsandru Ioan Baba,Cornel Cătoi |
Publsiher | : Unknown |
Total Pages | : 787 |
Release | : 2007 |
Genre | : Electronic books |
ISBN | : 9732714573 |
Download Comparative Oncology Book in PDF, Epub and Kindle
How Tobacco Smoke Causes Disease
Author | : Anonim |
Publsiher | : Unknown |
Total Pages | : 728 |
Release | : 2010 |
Genre | : Government publications |
ISBN | : UCSD:31822037817723 |
Download How Tobacco Smoke Causes Disease Book in PDF, Epub and Kindle
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Cellular Adhesion in Development and Disease
Author | : Anonim |
Publsiher | : Academic Press |
Total Pages | : 536 |
Release | : 2015-02-27 |
Genre | : Science |
ISBN | : 9780124078895 |
Download Cellular Adhesion in Development and Disease Book in PDF, Epub and Kindle
Cell adhesion is a fundamental determinant of embryonic development and organogenesis. Cellular Adhesion in Development and Disease, volume 112 in Current Topics in Developmental Biology, comprehensively surveys current developments in understanding how adhesion systems affect organismal development. Topics covered include nectins, nectin-like molecules, and afadin in development; cadherin adhesion, signaling, and morphogenesis; endothelial cell junctions; epidermal development and barrier formation; and more. This book surveys current understanding of how adhesion systems affect organismal development
Proprotein Convertases in Gynecological Cancers
Author | : Daniel Bassi |
Publsiher | : Morgan & Claypool Publishers |
Total Pages | : 51 |
Release | : 2012 |
Genre | : Cancer |
ISBN | : 9781615044641 |
Download Proprotein Convertases in Gynecological Cancers Book in PDF, Epub and Kindle
Gynecological cancers include neoplasias of internal female genital organs, mainly ovarian, endometrial and cervical tumors, and cancers of the external female genital structures. Current scientific evidence indicates that both up- and down-regulation of the expression of PCs are part of the multiple changes occurring in these gynecological tumors. Nevertheless, the physiological significance of this puzzling pattern of PC expression remains elusive. The fact that PCs can activate both pro- and anticarcinogenic substrates may indicate that the nature of the overexpressed substrates in certain cancer types could determine the final outcome; i.e., slowing or accelerating cancer development.