Rna Based Regulation In Human Health And Disease

RNA-based Regulation in Human Health and Disease offers an in-depth exploration of RNA mediated genome regulation at different hierarchies. Beginning with multitude of canonical and non-canonical RNA populations, especially noncoding RNA in human physiology and evolution, further sections examine the various classes of RNAs (from small to large noncoding and extracellular RNAs), functional categories of RNA regulation (RNA-binding proteins, alternative splicing, RNA editing, antisense transcripts and RNA G-quadruplexes), dynamic aspects of RNA regulation modulating physiological homeostasis (aging), role of RNA beyond humans, tools and technologies for RNA research (wet lab and computational) and future prospects for RNA-based diagnostics and therapeutics. One of the core strengths of the book includes spectrum of disease-specific chapters from experts in the field highlighting RNA-based regulation in metabolic & neurodegenerative disorders, cancer, inflammatory disease, viral and bacterial infections. We hope the book helps researchers, students and clinicians appreciate the role of RNA-based regulation in genome regulation, aiding the development of useful biomarkers for prognosis, diagnosis, and novel RNA-based therapeutics. Comprehensive information of non-canonical RNA-based genome regulation modulating human health and disease Defines RNA classes with special emphasis on unexplored world of noncoding RNA at different hierarchies Disease specific role of RNA - causal, prognostic, diagnostic and therapeutic Features contributions from leading experts in the field

A huge number of messenger RNAs (mRNAs) and non-coding RNAs must be accurately expressed for cells to function normally. These RNAs take a role in transcription, RNA processing, and translation. An in-depth examination of RNA-mediated genome regulation at several levels has been provided in the book RNA-based Regulation in Human Health and Disease. Starting with the Introduction of RNA, RNA as a therapeutic target, a further section examines the various diseases and significant potential for RNA-based medicines and diagnostics in the future. The book helps researchers, students and clinicians across the world who will find this book very informative as well as practical.

Transcription and Translation in Health and Disease provides a detailed overview of the regulators underlying transcription and translation in relation to a variety of human diseases and disorders. Beginning with an introduction into the current perspectives relating to these processes in human disease, the book expands to focus on specific mechanisms underlying conditions such as arthritis, cancer, neurological disorders, diabetes and cardiovascular disease. This book considers RNA processing and related mechanisms in eukaryotes including RNA splicing, RNA binding proteins, RNA interference, microRNAs, RNA editing, transcription factors, RNAi screening, CRISPR activation, CRISPR-Cas9 interference, and post-translational modifications. It provides a structured and detailed overview of the various regulators underlying molecular processes and their impact on health and disease, equipping readers with the necessary knowledge for further investigation in the areas of treatment and therapeutic intervention. Discusses the role played by transcription and translational regulation in various diseases, including cancer, diabetes, cardiovascular disease and neurological disease Considers a range of post-transcriptional regulators, including RNA-binding proteins, non-coding RNAs, epigenetic modifiers, alternative splicing and telomerase-binding proteins Covers the topic from fundamental knowledge to the latest developments in clinical application Includes a section dedicated to therapeutic applications

Epigenetics in Health and Disease, Volume 198 in the Progress in Molecular Biology and Translational Science series, highlights new advances in the field, with this new volume presenting interesting chapters on Computational biology in epigenetics, Artificial intelligence and machine learning in epigenetics, CRISPR-dCas9 Systems for Epigenetic Editing for Therapeutic Applications, Epigenetics in heredity disease, Epigenetics in cancer development, diagnosis and therapy, Microbiota and epigenetics: health impact, Histone deacetylase (HDACs) Inhibitors: Clinical applications, Early epigenetic markers for precision medicine, Epigenetics of neurological diseases, Epigenetic Regulons in Alzheimer’s disease, and Epigenetics in epilepsy. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Progress in Molecular Biology and Translational Science series Includes the latest information on Epigenetics in Health and Disease

Microbiome Therapeutics: Personalized Therapy Beyond Conventional Approaches addresses the current knowledge and landscape of microbiome therapeutics, providing an overview of existing applications in health and disease as well as potential future directions of microbiome modulations and subsequent translation to the global industry and market. This important reference provides the most current status of microbiome therapeutics as well as possible future perspectives through coverage of topics including the application of microbiome therapeutics; various additive, subtractive and modulatory approaches; microbiome composition of health and diseases, insights into live bio-therapeutics and the clinical data supporting their efficacy. Case studies are provided throughout the book to further define, describe and evaluate microbiome therapeutics success and failure. Provides chapters focused on illness types to address the potential of microbiome therapeutics in several significant disorders Offers human gut microbiome explorations that have enriched the understanding of microbiome colonization, maturation, and dysbiosis in health and disease subsets Addresses important concepts like economic potential in the global therapeutics market as well as ethical, technical, and regulatory aspects

The Impact of Nanoparticles on Agriculture and Soil, part of the Nanomaterials-Plant Interaction series, contributes the most recent insights into understanding the cellular interactions of nanoparticles in an agricultural setting, focusing on current applications and means of evaluating future prospects. In order to ensure and improve the biosafety of nanoparticles, it is a primary concern to understand cellular bioprocess like nanomaterial’s cellular uptake and their influence on cellular structural, functional and genetic components. This book addresses these and other important aspects in detail along with showcasing their applications in the area of agriculture. With an international team of authors, and experienced editors, this book will be valuable to those working to understand and advance nanoscience to benefit agricultural production and human and environmental welfare. In-depth knowledge of these bioprocess will enable researchers to engineer nanomaterials for enhanced biosafety. Guides the assessment of nanomaterials’ impact on agricultural and soil cellular metabolism and physiological characteristics Provides in-depth insights into potential risks and hazards of nanoparticles Builds a foundation for further research and development

This Research Topic addresses the human diseases caused by a malfunction of the RNA metabolism. We aim at strengthening the link between fundamental research and therapeutic applications. In eukaryotes, RNA is transcribed from genomic DNA. RNA molecules undergo multiple post-transcriptional processes such as splicing, editing, modification, translation, and degradation. A defect, mis-regulation, or malfunction of these processes often results in diseases in humans, referred to as 'RNA diseases'. There is an increasing number of studies focused on RNA diseases, which are aimed at uncovering the fundamental molecular mechanisms at play in order to develop therapeutic approaches.