Salvage Therapy For Prostate Cancer

This book comprehensively covers application of salvage therapy in reccurrent prostate cancer. Chapters focus on specific issues associated with a range of surgical and oncological management techniques and strategies including hormone therapy, lymphnode dissection, robotic prostatectomy and salvage reirradiation after locoregional failure. Learning objectives, and definitions of keywords are provided to aid the reader develop a thorough understanding of the topic and reinforce the key points covered in each chapter. Salvage Therapy for Prostate Cancer provides a detailed practically applicable guide on how salvage therapy can be utilised in the treatment of prostate cancer. It represents a valuable resource for trainee and practicing urologists, oncologists, and specialist nurses.

Today, the arsenal of “high-precision” or “targeted” radiotherapy includes a variety of techniques and approaches that, like the pieces of a puzzle, need to be put together to provide the prostate cancer patient with high-level optimized radiation treatment. This book examines in detail the role of these innovative radiation techniques in the management of prostate cancer. In addition, a variety of current controversies regarding treatment are carefully explored, including whether prophylactic treatment of the pelvic lymphatics is essential, the magnitude of the effect of dose escalation, whether a benefit accrues from hypofractionation, and what evidence exists for the superiority of protons or heavy ions. Radiotherapy in Prostate Cancer: Innovative Techniques and Current Controversies is intended for both radiation oncologists and urologists with an interest in the up-to-date capabilities of modern radiation oncology for the treatment of prostate cancer.

The use of radical prostatectomy in patients with high risk of recurrence has significantly increased during the past 10 years. Thus, adjuvant radiation as a part of multimodality treatment or salvage radiation at the evidence of prostate-specific antigen (PSA) progression represents mainstay curative-intent options for a great number of prostate cancer patients. Although, few randomized trials and many retrospective studies have been published, many uncertainties still mold the discussions on the best treatment management for men after prostatectomy. This research topic successfully intended to foster discussions on current controversies in the use of postoperative radiotherapy and to present novel perspectives for treatment optimization.

This User’s Guide is a resource for investigators and stakeholders who develop and review observational comparative effectiveness research protocols. It explains how to (1) identify key considerations and best practices for research design; (2) build a protocol based on these standards and best practices; and (3) judge the adequacy and completeness of a protocol. Eleven chapters cover all aspects of research design, including: developing study objectives, defining and refining study questions, addressing the heterogeneity of treatment effect, characterizing exposure, selecting a comparator, defining and measuring outcomes, and identifying optimal data sources. Checklists of guidance and key considerations for protocols are provided at the end of each chapter. The User’s Guide was created by researchers affiliated with AHRQ’s Effective Health Care Program, particularly those who participated in AHRQ’s DEcIDE (Developing Evidence to Inform Decisions About Effectiveness) program. Chapters were subject to multiple internal and external independent reviews. More more information, please consult the Agency website: www.effectivehealthcare.ahrq.gov)

Carcinoma of the prostate increasingly dominates the attention of urologists for both scientific and clinical reasons. The search for an explanation and the prediction of the variable behaviour of the malignant prostatic cell continues unabated. The search for more precise tumour staging and more effective treatment is equally vigorous. Editors Andrew Bruce and John Trachtenberg have assembled acknowledged leaders in prostate cancer to present those areas of direct interest to the clinician. There are a number of other topics that might have been considered but most of these, such as experimental tumour models or biochemical factors affecting cell growth, still lack immediate application for the clinician. Carcinoma of the prostate continues to have its highest incidence in the western world, and the difference in comparison with the incidence in the Far East appears to be real and not masked by diagnostic or other factors. A number of other epidemiological aspects need careful analysis: Is the incidence increasing? Is the survival improving? Is the prognosis worse in the younger patient? Epidemiological data are easily misused and misinterpreted so that a precise analysis of the known facts makes an important opening chapter to this book.

Increasingly routine use of prostate surface antigen (PSA)-based screening has led to the diagnosis of more patients with organ-confined prostate cancer. These localised cancers are routinely treated with radical prostatectomy, external beam radiation therapy or prostate brachytherapy. Prostate brachytherapy is an appealing treatment for reasons including patient convenience, a favourable toxicity profile and cost-effectiveness. Consequently, the utilisation of brachytherapy is increasing, both in the United States and around the world. This book examines the increasing use of prostate brachytherapy as a treatment method, as well as the numerous reasons why this particular type of treatment is providing positive results.

This book provides a 2015 state of the art update on the hot topic of focal prostate cancer therapy, which offers a means of preserving the prostate and avoiding major side-effects associated with conventional treatment strategies. In so doing, focal therapy meets the desire of many patients, especially those with low-risk disease, to avoid or postpone radical therapies in order to preserve quality of life. A wide range of aspects are covered, including the role of imaging-guided targeted biopsies, the pros and cons of surveillance in comparison with focal therapy, focal hemiablation and focal salvage therapy, multifocal therapies, focal cryotherapy. The potential role of various new diagnostic technologies as well as specific therapeutic devices as "Focal.One" robotic high-intensity focused ultrasound are explained. The authors are all international experts who are long-term proponents of non-invasive treatment of prostate cancer. "Focal Therapy of Prostate Cancer" will be an invaluable source of information for urologists, oncologists, radiation oncologists, and general practitioners, and also for patients wishing to learn more about this new treatment option.

PROSTATE! PROSTATE! PROSTATE! A Problem of Men, is an easy to read, informative, caring and compassionate journey of understanding of man's prostate, one of man's most important organs, bearing the responsibility for reproduction and making of new babies, yet very susceptible to potentially fatal diseases. This book explains the value of the prostate and the risks it faces, taking you on that journey with the authors, a prostate cancer survivor and a renowned urologist. You may turn back, jump forward, or repeat specific chapters as you journey. Every chapter is specific in it own rights. ---------------- One in six men will be diagnosed with prostate cancer and about 20% of them will die from it. Almost every man will have some form of problem with his prostate during his life. More than 95 percent of men who are diagnosed with prostate cancer, and the women in their lives, find themselves wanting to understand more about available treatment options, before they make their decision for choice of treatment. This book fills that information void by providing an abundance of information in an orderly fashion and helps with the understanding, education and relief. ------------------ The book was written to encourage men to get a regular medical check-up (yearly) and to take action quickly when they are diagnosed with a prostate problem, particularly prostate cancer. It describes what's needed to be known after a man is diagnosed with prostate cancer, including therapeutic options. It is written for the benefit, reading pleasure and learning of all men, and all women who have men in their lives. ------------------- Part I of the book (five chapters) addresses health habits and self-care, leading into nurturing the prostate and the benefits of nutritional supplements. ----------------------- Part II (five chapters) is about the Prostate, the major role it plays in your reproductive system, the diseases that can affect the prostate and your quality of life. ---------------------- Part III (10 chapters) deals with prostate cancer diagnosis, the steps taken to confirm that cancer is present, and its severity. --------------------- Part IV (seven chapters) deals with managing the condition, including your behavior tendencies, denial, breaking the news to family and friends, changing lifestyle and what the women in your life can do to help. -------------------- Part V (nine chapters) addresses the alternative treatment options, including the newest ones, after effects, and making the selection regarding treatment. --------------------- Part VI (nine chapters) addresses the surgery experience, hospital admission, treatment, what to expect, post-hospital care, subsequent visits to your urologist and finally recurrent cancer and salvage therapy. ------------------- Part VII includes the glossary, resources and index.