Sarcoidosis And Other Granulomatous Disorders

This concise reference offers expert diagnostic and treatment information. Topics covered include background history; clinical, radiologic and histologic features; differential diagnosis; immunology; markers of activity; epidemiology; and etiology.

Sarcoidosis is a multi-organ, granulomatous disease the etiology of which remains unknown. It is characterized by T-cell dysfunction and B-cell hyperactivity with increased local immune activity and inflammation that leads to the formation of noncaseating granulomas in the organs involved. The lung and lymphatic system are the most commonly affected organs, however virtually any organ may be affected. Other common sites of involvement include the skin, eye, central nervous system, and the heart. Patients may present different symptoms related to the disease stage and the specific organ involved. Sarcoidosis is a global disease, and its prevalence has increased twofold over the past years. Due to the clinical heterogeneity and variable diagnostic criteria in different countries, it is difficult to calculate the exact prevalence and incidence of sarcoidosis. Age, sex, race, and geographic origin significantly influence the incidence of sarcoidosis. The book at hand seeks to assess the current diagnostic techniques, imaging techniques, differential diagnosis of this disease, as well as other granulomatous diseases mimicking sarcoidosis.

Sarcoidosis is a generalized, systemic, and specific granulomatous disease involving many organs and systems. Diagnosis of sarcoidosis is challenging, especially when mediastinal lymph nodes and lungs are not affected. The symptoms of sarcoidosis depend on its location. Differential diagnosis of sarcoidosis among the other specific granulomatous diseases is difficult, particularly with tuberculosis on biopsy. The etiology of sarcoidosis is still unknown, but this book offers insights and explanations. It also presents guidelines for treatment.

This authoritative account of the granulomatous disorders provides a comprehensive overview of this complex group of diseases. Collectively, these disorders can present a bewildering array of symptoms, affecting all the body systems. This volume takes full account of recent advances in our knowledge of the molecular biology and immunology of these disorders, and casts fresh light on their diagnosis and treatment. This timely publication is organised to include chapters focused on causative agents and those addressing affected body systems. Highly illustrated throughout, including numerous colour plates, it encompasses and integrates the very latest science, pathology and practical clinical advice. Compiled by international authorities with chapters which combine the expertise of both a pathologist and clinician, it is sure to become an essential source of reference for a very wide readership including infectious disease specialists, immunologists, pathologists, radiologists, ophthalmologists and general physicians.

Sarcoidosis is a rare condition that causes small patches of red and swollen tissue, called granulomas, to develop in the organs of the body. It most often affects the lungs and skin. Typical symptoms include tender, red bumps on the skin, shortness of breath and a persistent cough. There is no cure for sarcoidosis, but the condition often improves without treatment within a few months or years. Sarcoidosis is estimated to affect about 1 in every 10,000 people in the UK (NHS Choices). Part of the Clinical Focus Series, this book provides trainees with an overview of this complex condition. Beginning with an introduction and guidance on recognising pulmonary granulomas, the following chapters provide in depth coverage of numerous common lesions, describing their history, clinical features, differential diagnosis and treatment. Presented in an easy to read format, this useful reference includes clinical photographs, CT scans and X-rays, histological pictures and tables to enhance learning. Key points Provides practical overview of lesions of sarcoidosis Covers numerous common lesions, their history, clinical features, diagnosis and treatment Presented in easy to read format, with problem solving approach Includes clinical photographs, CT Scans, X-rays, histological pictures and tables