Snp

By any measure, the story of the Scottish National Party is an extraordinary one. Forced to endure decades of electoral irrelevance since its creation in the 1930s, during which it often found itself grappling with internal debate on strategy, and rebellion from within its own ranks, the SNP virtually swept the board in the 2015 general election, winning all but three of Scotland's fifty-nine seats in Westminster. What's more, under the current leadership of Nicola Sturgeon, the SNP has never been a more important force in the landscape of British politics. The leaders who have stood at its helm during this tumultuous eighty-year history - from Sir Alexander MacEwen to Nicola Sturgeon and Alex Salmond - have steered the SNP vessel with varying degrees of success, but there is no doubt that all have contributed to the shape, purpose and ultimate goal of the party of government we see today. The latest addition to the acclaimed British Political Leaders series, Scottish National Party Leaders examines each of these senior figures for the first time, and is essential reading for anyone curious about how this former fringe party evolved into a political phenomenon, changing not only the face of Scottish politics, but British politics as well.

Based on an unprecedented survey of the entire membership and over 80 elite interviews The Scottish National Party is the definitive account of the nature of the SNP following its election as a party of government for the first time in its eighty year history.

The Scottish National Party has played a significant role in the politics of Scotland in the last forty years. In particular it has contributed to and shaped the impact and dynamics of devolution. This collection brings together academics, writers, commentators and analysts of Scottish politics to address the nature of the SNP: its position in Scotland, its influence on devolution, its role as a minority administration and its relationship with other institutions in Scotland, the UK and Europe.

Though the SNP has existed since 1934, no full-length history of the Scottish National Party was written until the first edition of this book in 2002. With the SNP having governed Scotland since 2007, and with an outright majority since 2011, the long-held SNP policy of an Independence Referendum is now a reality and scheduled to be held in 2014.

A Nation Changed? Provides the first detailed and wide-ranging analysis of the SNP in office. It looks at how Scotland has changed and not changed during that time, and the challenges that lie ahead. The book examines the SNP's record, its role as a government and as a party, detailed policy issues such as education and health, the Brexit conundrum and independence. Offering insights and suggestions for further action and reform, A Nation Changed? brings together an unparalleled range of knowledgeable and expert voices all of whom care deeply about Scotland, public policy, the state of democracy, and the future of our nation. Irrespective of your political views or allegiance, this groundbreaking study offers fresh thinking, food for thought and ideas for debate concerning the changing terrain of Scottish politics.

In recent years, single nucleotide polymorphisms have received increased and special attention in a rapidly developing field of personalized medicine and drug treatment. Comprising more than eighty percent of all known polymorphisms, single nucleotide polymorphisms (SNPs) are primarily responsible for phenotypic differences between individuals, and have been suggested to affect the development of diseases in humans and the response to drug treatment and environmental stress. In Single Nucleotide Polymorphisms: Methods and Protocols, Second Edition, expert researchers explore the latest advances in this area, highlighting the substantial progress that has been made in SNP genotyping, examining recent developments in high-throughput genotyping approaches, and exploring our new understanding of the impact of SNPs on gene function. Chapters address the impact of SNPs on phenotype, examine SNP databases, look at methods that have been applied for SNP bioinformatics discovery and analysis, and discuss advanced experimental approaches used for SNP detection. Composed in the highly successful Methods in Molecular BiologyTM series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls. Current and innovative, Single Nucleotide Polymorphisms: Methods and Protocols, Second Edition is an essential guidebook for individual researchers as well as institutions and companies working in the field.

Praise from the reviews: "Without reservation, I endorse this text as the best resource I've encountered that neatly introduces and summarizes many points I've learned through years of experience. The gems of truth found in this book will serve well those who wish to apply bioinformatics in their daily work, as well as help them advise others in this capacity." CIRCGENETICS "This book may really help to get geneticists and bioinformaticians on 'speaking-terms'... contains some essential reading for almost any person working in the field of molecular genetics." EUROPEAN JOURNAL OF HUMAN GENETICS "... an excellent resource... this book should ensure that any researcher's skill base is maintained." GENETICAL RESEARCH “… one of the best available and most accessible texts on bioinformatics and genetics in the postgenome age… The writing is clear, with succinct subsections within each chapter….Without reservation, I endorse this text as the best resource I’ve encountered that neatly introduces and summarizes many points I’ve learned through years of experience. The gems of truth found in this book will serve well those who wish to apply bioinformatics in their daily work, as well as help them advise others in this capacity.” CIRCULATION: CARDIOVASCULAR GENETICS A fully revised version of the successful First Edition, this one-stop reference book enables all geneticists to improve the efficiency of their research. The study of human genetics is moving into a challenging new era. New technologies and data resources such as the HapMap are enabling genome-wide studies, which could potentially identify most common genetic determinants of human health, disease and drug response. With these tremendous new data resources at hand, more than ever care is required in their use. Faced with the sheer volume of genetics and genomic data, bioinformatics is essential to avoid drowning true signal in noise. Considering these challenges, Bioinformatics for Geneticists, Second Edition works at multiple levels: firstly, for the occasional user who simply wants to extract or analyse specific data; secondly, at the level of the advanced user providing explanations of how and why a tool works and how it can be used to greatest effect. Finally experts from fields allied to genetics give insight into the best genomics tools and data to enhance a genetic experiment. Hallmark Features of the Second Edition: Illustrates the value of bioinformatics as a constantly evolving avenue into novel approaches to study genetics The only book specifically addressing the bioinformatics needs of geneticists More than 50% of chapters are completely new contributions Dramatically revised content in core areas of gene and genomic characterisation, pathway analysis, SNP functional analysis and statistical genetics Focused on freely available tools and web-based approaches to bioinformatics analysis, suitable for novices and experienced researchers alike Bioinformatics for Geneticists, Second Edition describes the key bioinformatics and genetic analysis processes that are needed to identify human genetic determinants. The book is based upon the combined practical experience of domain experts from academic and industrial research environments and is of interest to a broad audience, including students, researchers and clinicians working in the human genetics domain.