Stability And Characterization Of Protein And Peptide Drugs
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Stability and Characterization of Protein and Peptide Drugs
Author | : Rodney Pearlman,Y. John Wang |
Publsiher | : Springer Science & Business Media |
Total Pages | : 371 |
Release | : 2013-06-29 |
Genre | : Medical |
ISBN | : 9781489912367 |
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This is the first volume to make available specific case histories of therapeutic proteins and peptides that have been marketed or are currently under clinical testing. The editors have selected a wide range of molecules derived from monoclonal antibodies, recombinant DNA, and natural and chemical sources to provide formulation scientists with practical examples of the development of pharmaceutical products.
Formulation Characterization and Stability of Protein Drugs
Author | : Rodney Pearlman,Y. John Wang |
Publsiher | : Springer Science & Business Media |
Total Pages | : 432 |
Release | : 2006-04-11 |
Genre | : Medical |
ISBN | : 9780306474521 |
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Leading scientists offer detailed profiles of ten protein drugs currently in development. The case histories of these important new compounds are described from the perspective of their formulation, characterization, and stability. This ready reference also features recent data and an abundance of previously unpublished information. The in-depth coverage includes a highly useful compendium of degradation sites occurring in over 70 proteins. An invaluable aid in the rapid identification of potential `hot spots' in proteins, this accessible compilation allows for inspection of the protein's primary structure and preparation of a hydroflex plot.
Protein and Peptide Mass Spectrometry in Drug Discovery
Author | : Michael L. Gross,Guodong Chen,Birendra Pramanik |
Publsiher | : John Wiley & Sons |
Total Pages | : 484 |
Release | : 2011-09-26 |
Genre | : Medical |
ISBN | : 9781118116548 |
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The book that highlights mass spectrometry and its application in characterizing proteins and peptides in drug discovery An instrumental analytical method for quantifying the mass and characterization of various samples from small molecules to large proteins, mass spectrometry (MS) has become one of the most widely used techniques for studying proteins and peptides over the last decade. Bringing together the work of experts in academia and industry, Protein and Peptide Mass Spectrometry in Drug Discovery highlights current analytical approaches, industry practices, and modern strategies for the characterization of both peptides and proteins in drug discovery. Illustrating the critical role MS technology plays in characterizing target proteins and protein products, the methods used, ion mobility, and the use of microwave radiation to speed proteolysis, the book also covers important emerging applications for neuroproteomics and antigenic peptides. Placing an emphasis on the pharmaceutical industry, the book stresses practice and applications, presenting real-world examples covering the most recent advances in mass spectrometry, and providing an invaluable resource for pharmaceutical scientists in industry and academia, analytical and bioanalytical chemists, and researchers in protein science and proteomics.
Physical Methods to Characterize Pharmaceutical Proteins
Author | : James N. Herron,Wim Jiskoot,Daan J.A. Crommelin |
Publsiher | : Springer Science & Business Media |
Total Pages | : 374 |
Release | : 2013-11-21 |
Genre | : Medical |
ISBN | : 9781489910790 |
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Proteins are still gaining importance in the pharmaceutical world, where they are used to improve our arsenal of therapeutic drugs and vaccines and as diagnostic tools. Proteins are different from "traditional" low-molecular-weight drugs. As a group, they exhibit a number of biopharmaceutical and formulation problems. These problems have drawn considerable interest from both industrial and aca demic environments, forcing pharmaceutical scientists to explore a domain previ ously examined only by peptide and protein chemists. Biopharmaceutical aspects of proteins, e.g., low oral bioavailability, have been extensively investigated. Although all possible conventional routes of ad ministration have been examined for proteins, no real, generally applicable alter native to parenteral administration in order to achieve systemic effects has yet been discovered. Several of these biopharmaceutical options have been discussed in Volume 4 of this series, Biological Barriers to Protein Delivery. Proteins are composed of many amino acids, several of which are notorious for their chemical instability. Rational design of formulations that optimize the native structure and/or bioactivity of a protein is therefore of great importance when long shelf life is required, as it is for pharmaceutical products. This issue has also been examined in two prior volumes of this series: Volume 2: Stability of Protein Pharmaceuticals (Part A) and Volume 5: Stability and Characterization of Protein and Peptide Drugs.
Peptide and Protein Drug Analysis
Author | : Ronald Reid |
Publsiher | : CRC Press |
Total Pages | : 918 |
Release | : 1999-11-12 |
Genre | : Medical |
ISBN | : 1420001337 |
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Furthering efforts to simulate the potency and specificity exhibited by peptides and proteins in healthy cells, this remarkable reference supplies pharmaceutical scientists with a wealth of techniques for tapping the enormous therapeutic potential of these molecules-providing a solid basis of knowledge for new drug design. Provides a broad, comprehensive overview of peptides and proteins as mediators of cell movement, proliferation, differentiation, and communication. Written by more than 50 leading international authorities, Peptides and Protein Drug Analysis discusses strategies for dealing with the complexity of peptides and proteins in conformational flexibility and amino acid sequence variability analyzes drug formulations facilitated by solid-phase peptide synthesis and recombinant DNA technology examines chemical purity analysis by high-pressure chromatographic, capillary electrophoretic, gel electrophoretic, and isoelectric focusing methods highlights drug design elements derived from protein folding, bioinformatics, and computational chemistry demonstrates uses of unnatural mutagenesis and combinatorial chemistry explores mass spectrometry, protein sequence, and carbohydrate analysis illustrates bioassays and other new functional analysis methods surveys spectroscopic techniques such as ultraviolet, fluorescence, Fourier transform infrared, and nuclear magnetic resonance (NMR) addresses ways of distinguishing between levels of therapeutic and endogenous agents in cells reviews structural analysis tools such as ultracentrifugation and light, X-ray, and neutron scattering and more! Featuring over 3400 bibliographic citations and more than 500 tables, equations, and illustrations, Peptide and Protein Drug Analysis is a must-read resource for pharmacists; pharmacologists; analytical, organic, and pharmaceutical chemists; cell and molecular biologists; biochemists; and upper-level undergraduate and graduate students in these disciplines.
Protein Formulation and Delivery
Author | : Eugene J. McNally,Eugene McNally,Jayne E. Hastedt |
Publsiher | : CRC Press |
Total Pages | : 372 |
Release | : 2007-10-26 |
Genre | : Medical |
ISBN | : 9780849379529 |
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This title is intended to assist pharmaceutical scientists in the development of stable protein formulations during the early stages of the product development process, providing a comprehensive review of mechanisms and causes of protein instability in formulation development, coverage of accelerated stability testing methods and relevant analytica
Formulation Characterization and Stability of Protein Drugs
Author | : Rodney Pearlman,Y. John Wang |
Publsiher | : Unknown |
Total Pages | : 464 |
Release | : 2014-01-15 |
Genre | : Electronic Book |
ISBN | : 1475770464 |
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Therapeutic Protein and Peptide Formulation and Delivery
Author | : Zahra Shahrokh |
Publsiher | : Unknown |
Total Pages | : 248 |
Release | : 1997 |
Genre | : Dosage forms |
ISBN | : UOM:39015041771521 |
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This volume reviews protein stability and the analytical and biophysical characterization of proteins. It emphasizes drug delivery approaches, especially local delivery through the skin. Including both academic and industrial perspectives from such companies as Genentech, Amgen, and Merck, the book also discusses novel drug delivery polymers and the development of pharmaceutical protein formulations.