Stereochemical Aspects Of Organolithium Compounds

Topics in Stereochemistry, previously edited by "the father of stereochemistry" Ernest L. Eliel, is a longstanding, successful series covering the most important advances in the field. The much-anticipated Volume 26 on stereochemical aspects of organolithium compounds includes chapters on the following topics: * Asymmetric Deprotonations Using Chiral Lithium Amide Bases * Self-Regeneration of Stereocenters (SRS) via Stereolabile Axially Chiral Intermediates * Overview of Carbanion Dynamics and Electrophilic Substitutions in Chiral Organolithium Compounds * Oxiranyllithiums as Chiral Synthons for Asymmetric Synthesis * Test on the Configurational Stability/Lability of Organolithium Compounds * Mechanism and Stereochemical Features in Asymmetric Deprotonation Using RLi/(-)-Sparteine Bases * Dynamic Resolutions of Chiral Organolithiums Volume 26 of Topics in Stereochemistry marks the end of an era, while developing a bridge to the next generation. A new generation in publishing, parallel to a new generation in Stereochemistry mandated a new venue and modus operandi for Topics. Zurich, the home of Werner and Wislicenus, has a unique heritage in Stereochemistry. Fortunately, the Wiley family's publishing partnerships include Verlag Helvetica Chimica Acta, a house with a reputation for superior quality in publishing. Indeed, within the pages of its namesake periodical, Helvetica Chimica Acta, one finds many of the seminal research works of stereochemistry's giants. As such, a transfer of editorial operations to Zurich and a collaboration bringing Topics as a series closer to periodical status provides a growth platform for the future.

The Chemistry of Organolithium Compounds is a comprehensive review of the status of organolithium compound chemistry. This book is composed of four parts and nineteen chapters that particularly describe the reactions involving these compounds The first part highlights the constitution of organolithium compounds, specifically in the absence and presence of electron donors, as well as the configurational stability of these compounds. The second part deals with their preparation from organic halides and lithium metal involving metallation and metal-halogen exchange, while the third part focuses on their organic synthesis. The fourth part considers the synthesis of organometallic compound derivatives from main group and transition metals. This book will prove useful to organic chemists and organic chemistry researchers.

The impact of organosulfur chemistry, especially in the areas of heterocyclic chemistry, stereocontrolled processes, and asymmetric synthesis, has led to a resurgence of interest in the field. This book is the secondin a series intended to provide coverage of topics of current interest throughout the whole range of organosulfur chemistry. Each volume is comprised of five or six chapters, each consisting of an in-depth, self-contained review in a well-defined area. This volume and its predecessor Organosulfur Chemistry, Synthetic Aspects will prove valuable references for researchers and practitioners in organic chemistry. Methods of asymmetric sulfur oxidation processes Preparation of chiral sulfoxides in nucleophilic displacement at sulfur Conformational preferences of the sulfinyl group Preparation and chemistry of unsaturated sulfoxides Applications of sulfoxides as stereocontrol elements The chemistry of sulfolenes

A thorough understanding of stereochemistry is essential for the comprehension of almost all aspects of modern organic chemistry. It is also of great significance in many biochemical and medicinal disciplines, since the stereoisomers of a compound can have dramatically different biological properties. This text explains how the different properties of stereoisomers of a compound arise, and what processes can be used to prepare and analyze stereoisomerically pure compounds. It also presents prominent coverage of the stereochemistry of inorganic and organometallic compounds, which is likely to increase in importance, as these compounds are used as symmetric catalysts in asymmetric synthesis. Modern stereochemical terminology is used throughout, although reference is also made to older terms which are still widely used. A set of problems at the end of each chapter aims to further the reader's understanding of how the content can be applied. The book is designed mainly as a textbook for undergraduate students and as a reference source for more advanced levels, but is also intended for academic and professional organic chemists.

This is the first volume in the series to concentrate on organo-lithium compounds - the sub series "The chemistry of the metal-carbon bond" (5 vol) treated organometallics in general. It deals with theoretical/physical/computational apsects, as well as major spectroscopies, such as MS, NMR, IR/UV etc and both biological and industrial applications. The core of the volume is the synthetic chapters with lots of examples for modern synthetic approaches Written by key researchers in the field An invaluable reference source to organic chemists working in academia and industry Features important reagents in organic synthesis

This unique book covers fundamentals of organolithium compounds and gives a comprehensive overview of the latest synthetic advances and developments in the field. Part I covers computational and spectroscopic aspects as well as structure-reactivity relationships of organolithiums, whereas Part II deals with new lithium-based synthetic methodologies as well as novel synthetic applications of functionalized lithium compounds. A useful resource for newcomers and active researchers involved in organic synthesis, whether working in academia or industry!

This volume, number 23 in the "Tetrahedron Organic Chemistry" series, presents organolithium chemistry from the perspective of a synthetic organic chemist, drawing from the synthetic literature to present a unified overview of how organolithiums can be used to make molecules. The development of methods for the regioselective synthesis of organolithiums has replaced their image of indiscriminate high reactivity with one of controllable and subtle selectivity. Organolithium chemistry has a central role in the selective construction of C-C bonds in both simple and complex molecules, and for example has arguably overtaken aromatic electrophilic substitution as the most powerful method for regioselective functionalisation of aromatic rings. The twin themes of reactivity and selectivity run through the book, which reviews the ways by which organolithiums may be formed and the ways in which they react. Topics include advances in directed metallation, reductive lithiation and organolithium cyclisation reactions, along with a discussion of organolithium stereochemistry and the role played by ligands such as (-)-sparteine.

Chiral Building Blocks in Asymmetric Synthesis A comprehensive introduction to the important classes of chiral building blocks Chirality — the asymmetric quality found in certain chemical compounds — plays an essential role in our world: chiral compounds can be found in biology, pharmaceutical compounds, agrochemicals, and fragrances. The stereoselective preparation of these complex molecular constructions constitutes a challenge. To this end, modern asymmetric synthesis utilizes a variety of valuable and efficient reagents employed as chiral auxiliaries, metal complexes and organocatalysts in stereoselective catalysis, and enantiopure reactants termed as chiral building blocks. In Chiral Building Blocks in Asymmetric Synthesis, the achievements in the fields of preparation of and applications of chiral blocks are presented. In doing so, the book comprehensively discusses the important classes of these reactants as the key for the asymmetric synthesis of chiral molecules. As such, it is an indispensable resource about synthetic methods, as well as possible modifications and transformations of important classes of chiral compounds. It also highlights the importance of their use as reactants and auxiliaries in the preparation of more sophisticated molecules or supramolecular systems. In Chiral Building Blocks in Asymmetric Synthesis readers will also find: Organization according to the most important compound classes — e.g. amino acids, BINOL and its derivatives, terpenes, and others — with an emphasis on synthesis and application A focus on the use of chiral building blocks for the preparation of bioactive compounds and supramolecular assemblies Chiral Building Blocks in Asymmetric Synthesis is a useful reference for organic chemists, catalytic chemists, chemists in industry, medicinal chemists, pharmaceutical chemists, and the libraries that support them.