Surgical Pathology Of Liver Tumors

This text provides a practical guide for the diagnostic surgical pathologist in evaluating tumors involving the liver. It comprehensively covers the histological findings and key clinical and molecular correlates of liver tumors. The focus is on material that is most relevant to the actual practice of liver pathology including those aspects that are directly relevant to the diagnosis, subtyping and prognostication of hepatic adenomas specimens, including biopsy specimens and surgical resections. The book will teach pathologists how to avoid common diagnostic pitfalls. Each chapter uses or discusses the nomenclature and classification system of liver tumors as per the current WHO classification of liver tumors. Each chapter fully incorporates the most up to date diagnostic methodologies, including immunohistochemistry and molecular methods. Referencing is succinct and references were carefully chosen for their key role as the primary sources of information on a given disease. The text is richly illustrated with beautiful color images that highlight not just the “average” histological findings for a given entity, but also fully illustrate all of the key histological variability. Gross images are also included to highlight important diagnostic features. Tables are used judiciously to present summary information that allows a quick review on how similar entities compare and contrast. In addition, the clinical significance of various diseases will be discussed in a focused fashion that highlights how pathology information is being used to make key clinical management decisions. Each chapter is written by experts in hepatopathology, all from the Mayo Clinic Departments of Pathology. Surgical Pathology of Liver Tumors will be of great utility to surgical pathologists and surgical pathologists in training as well as clinicians involved in the care of patients with liver tumors, particularly hepatologists and oncologists.

This unique book provides detailed insight into a wealth of expert experience in liver pathology, with an in-depth review of the expertÌs analysis and diagnostic process supported by high-quality color photomicrographs and discussion of the diagnostic principles involved in evaluating these lesions. The diagnostic problems and cases selected show the wide range of specimens seen in liver pathology and address the difficult issues in diagnosis encountered in these lesions. Chapters and cases are authored by many of the leading experts and educators in liver pathology today. Liver Pathology will be essential reading for every pathologist who evaluates liver pathology specimens. In addition it will be a valuable resource for pathology residents and fellows. All Consultant Pathology Titles Provide: Actual consultation cases and expert analysis Expert analysis provides a detailed discussion of the reasoning behind the diagnosis of each case Comprehensive coverage of challenging diagnoses The cases are richly illustrated with high-quality photomicrographs

This book covers all liver tumors and lesions that clinically and radiologically mimic liver tumors. It provides readers with a comprehensive overview of this complex and rapidly evolving field. All aspects of surgical pathology are addressed, supplemented by detailed presentations of the lesions’ cell-biologic and molecular features. In addition, the methods employed for diagnosis and diagnostic algorithms are discussed. It appeals to pathologists and hepatologists and serves as an invaluable aid to diagnosis.The field of liver tumors and tumor-like lesions in adults and children has experienced tremendous advances in recent years. Specifically, the recognition of novel entities, deepened insights into known tumors, and refinement of classifications have necessitated continual updates and reappraisals. In addition, previous understanding of hepatic carcinogenesis and tumor progression has been transformed by the very rapid evolution of our understanding of cell biology, genomics, signaling pathways, cell interactions, and mechanisms of invasion and spread of hepatic tumor cells. These general pathology issues must be combined with surgical pathology if a comprehensive understanding of liver tumor pathology is to be achieved.

For the surgical pathologist, this coverage of Liver Pathology presents practical information with ample discussion of differential diagnosis and use of special studies, where relevant, to engage pathologists in what you can do daily in practice. Topics include: Steatohepatitis: Histopathologic diagnosis; Regression and subclassification of cirrhosis; Autoimmune hepatitis and overlap syndrome; Liver transplant pathology: challenging diagnostic situations; Hepatocellular adenoma; Immunohistochemistry for the diagnosis of hepatocellular carcinoma; Histologic subtypes of hepatocellular carcinoma: diagnostics and clinical significance; Pediatric cholestatic disorders. Sanjay Kakar and Dhanpat Jain bring their expertise in liver pathology and lead a group of authors whose focus is on liver and GI pathology. The surgical pathologist has at hand in this issue the essential and most current aspects of liver pathology required for daily practice.

For the surgical pathologist, this coverage of Liver Pathology presents practical information with ample discussion of differential diagnosis and use of special studies, where relevant, to engage pathologists in what you can do daily in practice. Topics include: Steatohepatitis: Histopathologic diagnosis; Regression and subclassification of cirrhosis; Autoimmune hepatitis and overlap syndrome; Liver transplant pathology: challenging diagnostic situations; Hepatocellular adenoma; Immunohistochemistry for the diagnosis of hepatocellular carcinoma; Histologic subtypes of hepatocellular carcinoma: diagnostics and clinical significance; Pediatric cholestatic disorders. Sanjay Kakar and Dhanpat Jain bring their expertise in liver pathology and lead a group of authors whose focus is on liver and GI pathology. The surgical pathologist has at hand in this issue the essential and most current aspects of liver pathology required for daily practice.

This book focuses on the pathological diagnosis of primary hepatic and bile duct tumors, and introduces the “Three Types and Six Sub-types” classification of hepatobiliary tumors. With more than 600 figures, including photographs and microscopy images, it highlights morphology, immunology and molecular pathology and their correlations with hepatic surgery and hepatic oncology. The book reviews the pathobiological characteristics of hepatic tumors and reveals the latest developments in this field. It is a valuable reference resource for hepatologists, pathologists and researchers.

This one-of-a-kind reference provides a comprehensive and practical guide to help you interpret endoscopic biopsies and resection specimens of all organs related to the digestive system. The more than 2250 high quality illustrations, 30% more than in the first edition, help you recognize and diagnose any tissue sample under the microscope. Five new chapters, additional expert authors, expanded tables, and coverage of the current clinical approach to management and treatment options, particularly screening and surveillance recommendations for preneoplastic disorders, round out this unique reference. Acts as a one-stop resource for the entire gastrointestinal system, liver, biliary tract, and pancreas. Incorporates over 2250 high quality color illustrations so you can recognize and diagnose any tissue sample under the microscope. Provides all the necessary tools to make a comprehensive diagnostic workup including data from ancillary techniques and molecular findings whenever appropriate. Simplifies complex topics and streamlines decision-making using extensive tables, graphs, and flowcharts. Helps you avoid diagnostic errors thanks to practical advice on pitfalls in differential diagnosis. Uses a new “road map at the beginning of each chapter, as well as a new, more clinical focus to help you navigate through the book more quickly. Reflects the latest classification and staging systems available so you can provide the clinician with the most accurate and up-to-date diagnostic and prognostic indicators, including key molecular aspects of tumor pathology. Adds five new chapters including "Screening and Surveillance of the GI Tract , "Congenital and Developmental Disorders of the GI Tract , "Pediatric Enteropathies of the GI Tract", "Vascular Disorders of the GI Tract", and "Fatty Liver Disease". Expands appropriate chapters with new coverage of the normal histology of the GI tract, liver, biliary tract and pancreas. Uses expanded tables to outline specific differential diagnostic points helpful for surgical pathologists. Discusses the key molecular aspects of tumor progression and risk assessment in all chapters that cover neoplastic disorders. Helps you evaluate diagnostically challenging cases using diagnostic algorithms. Increases the number of high quality photographs by at least 30% to include even more normal and abnormal tissue samples. Updates all chapters to include the latest references, concepts, data, and controversies. Incorporates expanded coverage of the pancreas and liver, eliminating the need for a separate text.

Written by surgical pathologists for surgical pathologists, Surgical Pathology of the Liver focuses on sharpening your skills and knowledge in diagnostic histopathology, including laboratory and clinical findings that are directly useful when evaluating liver histology for clinical care. It offers comprehensive, superbly illustrated coverage of general liver pathology, as well as several chapters on topics that are not often included in liver pathology textbooks. Abundant high-quality illustrations have been carefully chosen to support and extend the information given in the text.