Surviving Sepsis

This book is open access under a CC BY 4.0 license. It constitutes a unique source of knowledge and guidance for all healthcare workers who care for patients with sepsis and septic shock in resource-limited settings. More than eighty percent of the worldwide deaths related to sepsis occur in resource-limited settings in low and middle-income countries. Current international sepsis guidelines cannot be implemented without adaptations towards these settings, mainly because of the difference in local resources and a different spectrum of infectious diseases causing sepsis. This prompted members of the Global Intensive Care working group of the European Society of Intensive Care Medicine (ESICM) and the Mahidol-Oxford Tropical Medicine Research Unit (MORU, Bangkok, Thailand) - among which the Editors – to develop with an international group of experts a comprehensive set of recommendations for the management of sepsis in resource-limited settings. Recommendations are based on both current scientific evidence and clinical experience of clinicians working in resource-limited settings. The book includes an overview chapter outlining the current challenges and future directions of sepsis management as well as general recommendations on the structure and organization of intensive care services in resource-limited settings. Specific recommendations on the recognition and management of patients with sepsis and septic shock in these settings are grouped into seven chapters. The book provides evidence-based practical guidance for doctors in low and middle income countries treating patients with sepsis, and highlights areas for further research and discussion.

The importance of early prevention and treatment of sepsis hasnever been greater. In the UK alone sepsis contributes to moredeaths than lung cancer, from bowel cancer and breast cancercombined, and approximately one third of patients who suffer fromsevere sepsis die. The ABC of Sepsis provides a much neededintroduction and an invaluable aid in the increasing efforts toreduce hospital infection and improve patient safety. As growing numbers of junior medical staff experience emergencymedicine, critical care and acute medicine as part of theFoundation Programme, there is an increasing need to develop theskills required to treat severe sepsis. The editors are involvedwith the Survive Sepsis campaign - developed to improve therecognition, diagnosis and treatment of sepsis - and are perfectlyplaced to guide junior medics, GPs, specialist nurses, criticalcare nurses and primary care staff through this core aspect ofacute medicine.

The second edition of the Oxford Handbook of Critical Care Nursing has been fully revised to reflect a more systematic approach to care delivery and to follow the patient pathway. Focused on the practical issues of nursing care and nursing procedures, this handbook has been written by nurses, for nurses. Reflecting current best practice, the Oxford Handbook of Critical Care Nursing is an easily accessible and evidence-based guide for all levels of nursing staff working in critical care environments. It provides the nurse at the bedside with the answers to day-to-day problems experienced when caring for critically ill patients, and is also a guide to some of the less commonly encountered issues. The new edition of this handbook will continue to help support novice and experienced staff in critical care environments. Now including more detail on the psychological issues facing critically ill patients, and more information on the intricacies of receiving a critically ill patient and transferring from a critical care environment, this handbook is a concise, practical, and comprehensive resource.

This book discusses recent progress in organ damage and tissue repair following severe trauma and sepsis. In part 1, it introduces the theory and clinical practice in organ damage. In part 2, it covers all the subjects of sepsis, ranging from mechanism, inflammation, and infection to the lung injury and neonatal sepsis. In part 3, it discusses 4 new advances techniques in tissue repair. There are 20 chapters contributed by experts in each area. This book is a valuable reference for scientists and clinicians to know the new knowledge and technology in severe trauma and sepsis, which will benefit their work in research and clinic through multidisciplinary collaboration.

This book is designed to provide a comprehensive and state-of-the-art resource for clinicians who care for patients with sepsis and research scientist alike, . Patients with severe sepsis requiring ICU admission have very high rates of ICU and overall hospital mortality, with estimates ranging from 18 to 50%. Risk factors for death from sepsis include underlying illness, increased age, and multi-system organ failure. This is compounded by the significant variation in the management of early severe sepsis. Care of these patients and clinical conditions can be quite complex, and materials are collected from the most current, evidence-based resources. Book sections have been structured to review the overall definitions and epidemiology of sepsis as well as current insights into the pathophysiology of sepsis. This review summarizes the evidence for the international consensus guidelines for the identification and management of sepsis. The latter part of this book reviews emerging concepts and approaches in the diagnosis and management of sepsis that may significantly reduce mortality in the future. Sepsis: Pathophysiology, Definitions and the Challenge of Bedside Management represents a collaboration between authors drawn from a variety of disciplines and contributions from basic scientists and highly recognized clinical opinion leaders with expertise in clinical trials.​

Drs. John C. Perkins and Michael E. Winters have assembled an expert team of authors on the topic of Sepsis in the Emergency Department. Article topics include: Defining and Diagnosing Sepsis; Appropriate Antibiotic Therapy; Severe Sepsis Resuscitation in Resource Limited Settings; Source Control in Severe Sepsis; Considerations in Special Populations with Severe Sepsis; Pediatric Severe Sepsis Resuscitation; The New Usual Care; Prehospital Sepsis Care; Endpoints of Sepsis Resuscitation; Pitfalls in the Diagnosis, Treatment, and Disposition of Severe Sepsis; Biomarkers in Sepsis; Vasopressors and Inotropes in Sepsis; and Sepsis Quality Measures and Performance Improvement.

This book, part of the European Society of Intensive Care Medicine textbook series, teaches readers how to use hemodynamic monitoring, an essential skill for today’s intensivists. It offers a valuable guide for beginners, as well as for experienced intensivists who want to hone their skills, helping both groups detect an inadequacy of perfusion and make the right choices to achieve the main goal of hemodynamic monitoring in the critically ill, i.e., to correctly assess the cardiovascular system and its response to tissue oxygen demands. The book is divided into distinguished sections: from physiology to pathophysiology; clinical assessment and measurements; and clinical practice achievements including techniques, the basic goals in clinical practice as well as the more appropriate hemodynamic therapy to be applied in different conditions. All chapters use a learning-oriented style, with practical examples, key points and take home messages, helping readers quickly absorb the content and, at the same time, apply what they have learned in the clinical setting. The European Society of Intensive Care Medicine has developed the Lessons from the ICU series with the vision of providing focused and state-of-the-art overviews of central topics in Intensive Care and optimal resources for clinicians working in Intensive Care.