Synthesis And Reactivity Of Donor Acceptor Substituted Aminocyclopropanes And Aminocyclobutanes
Download Synthesis And Reactivity Of Donor Acceptor Substituted Aminocyclopropanes And Aminocyclobutanes full books in PDF, epub, and Kindle. Read online free Synthesis And Reactivity Of Donor Acceptor Substituted Aminocyclopropanes And Aminocyclobutanes ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Synthesis and Reactivity of Donor Acceptor Substituted Aminocyclopropanes and Aminocyclobutanes
Author | : Florian de Nanteuil |
Publsiher | : Springer |
Total Pages | : 315 |
Release | : 2015-09-26 |
Genre | : Science |
ISBN | : 9783319230061 |
Download Synthesis and Reactivity of Donor Acceptor Substituted Aminocyclopropanes and Aminocyclobutanes Book in PDF, Epub and Kindle
This thesis presents a general approach to accessing nitrogen-substituted hetero- and carbocycles. In short, the annulation reactions developed in the thesis make it possible to access nitrogen-substituted four-, five- and six-membered rings, all essential building blocks for the synthesis of bioactive molecules. Many natural products display a saturated polycyclic core allowing a well-defined arrangement of functional groups in space. As such, they can interact with biological targets with a high degree of affinity and selectivity, surpassing many synthetic drugs. Nevertheless, the efficient synthesis of such complex ring systems poses a challenge for organic chemistry. Through careful tuning of the electronic properties of a nitrogen donor group and a diester acceptor group, the first [3+2] annulation reaction between aminocyclopropanes and enol ethers or carbonyl compounds is now possible. The reaction proceeded under mild catalytic conditions, and the building blocks obtained can be found at the core of bioactive alkaloids, drugs such as Ramipril and biomolecules such as DNA and RNA. Thanks to the dynamic kinetic asymmetric annulation of aminocyclopropanes with enol ethers and aldehydes, access to enantioenriched compounds is also now possible. Lastly, a synthesis of donor-acceptor aminocyclobutanes via [2+2] cycloaddition using a cheap iron catalyst was developed, allowing them to be used in [4+2] annulations to access cyclohexylamines.
Iron Catalysis
Author | : Bernd Plietker |
Publsiher | : Springer Science & Business Media |
Total Pages | : 227 |
Release | : 2011-01-05 |
Genre | : Science |
ISBN | : 9783642146695 |
Download Iron Catalysis Book in PDF, Epub and Kindle
Juan I. Padrón and Víctor S. Martín: Catalysis by means of Fe-based Lewis acids; Hiroshi Nakazawa*, Masumi Itazaki: Fe–H Complexes in Catalysis; Kristin Schröder, Kathrin Junge, Bianca Bitterlich, and Matthias Beller: Fe-catalyzed Oxidation Reactions of Olefins, Alkanes and Alcohols: Involvement of Oxo- and Peroxo Complexes; Chi-Ming Che, Cong-Ying Zhou, Ella Lai-Ming Wong: Catalysis by Fe=X Complexes (X=NR, CR2); René Peters, Daniel F. Fischer and Sascha Jautze: Ferrocene and Half Sandwich Complexes as Catalysts with Iron Participation; Markus Jegelka, Bernd Plietker: Catalysis by Means of Complex Ferrates.
Iron Catalysis in Organic Chemistry
Author | : Bernd Plietker |
Publsiher | : John Wiley & Sons |
Total Pages | : 295 |
Release | : 2008-09-08 |
Genre | : Science |
ISBN | : 9783527623280 |
Download Iron Catalysis in Organic Chemistry Book in PDF, Epub and Kindle
This first comprehensive book to cover this exciting field also deals with the biological aspects, such as enzymes with iron. Following an introduction, this handy reference and handbook goes on to deal with reductions, oxidations of C, H- and C=C bonds, oxidative allylic oxygenation and amination, the oxidation of heteroatoms, cross coupling reactions, aromatic and nucleophilic substitutions, addition to carbonyl compounds, and cyclisations as well as ring opening reactions. The chapters are clearly classified according to the reaction type, allowing readers to quickly locate the desired information.
Catalytic Reduction in Organic Synthesis
Author | : Johannes G. de Vries |
Publsiher | : Thieme Chemistry |
Total Pages | : 0 |
Release | : 2018 |
Genre | : Catalysis |
ISBN | : 3132406228 |
Download Catalytic Reduction in Organic Synthesis Book in PDF, Epub and Kindle
Catalytic reductions are among the most used synthetic transformations, and the past 15 years have seen great progress in this field. Science of Synthesis: Catalytic Reduction in Organic Synthesis includes the latest developments, as well as selective coverage of more well-established methods. Both heterogeneous and homogeneous catalytic systems are covered, and enantioselective methodology is well represented. There is a focus on the use of metal nanoparticles, both in suspension as well as on solid supports. Furthermore, the advent of research on the conversion of renewable resources into fuels and chemicals has given a great impetus to the field, as deoxygenations are often the first step in the conversion of biomass and this can often be achieved using hydrogenation or hydrogenolysis reactions. Scope, limitations, and mechanism of the reactions are discussed and key experimental procedures are included.
Methods and Applications of Cycloaddition Reactions in Organic Syntheses
Author | : Nagatoshi Nishiwaki |
Publsiher | : John Wiley & Sons |
Total Pages | : 996 |
Release | : 2013-12-17 |
Genre | : Science |
ISBN | : 9781118778203 |
Download Methods and Applications of Cycloaddition Reactions in Organic Syntheses Book in PDF, Epub and Kindle
Advanced tools for developing new functional materials and applications in chemical research, pharmaceuticals, and materials science Cycloadditions are among the most useful tools for organic chemists, enabling them to build carbocyclic and heterocyclic structures. These structures can then be used to develop a broad range of functional materials, including pharmaceuticals, agrochemicals, dyes, and optics. With contributions from an international team of leading experts and pioneers in cycloaddition chemistry, this book brings together and reviews recent advances, trends, and emerging research in the field. Methods and Applications of Cycloaddition Reactions in Organic Syntheses focuses on two component cycloadditions, with chapters covering such topics as: N1 unit transfer reaction to C–C double bonds [3+2] Cycloaddition of α, β-unsaturated metal-carbene complexes Formal [3+3] cycloaddition approach to natural product synthesis Development of new methods for the construction of heterocycles based on cycloaddition reaction of 1,3-dipoles Cycloreversion approach for preparation of large π-conjugated compounds Transition metal-catalyzed or mediated [5+1] cycloadditions Readers will learn methods for seamlessly executing important reactions such as Diels-Alder and stereoselective dipolar reactions in order to fabricate heterocyclic compounds, natural products, and functional molecules. The book not only features cutting-edge topics, but also important background information, such as the contributors’ process for developing new methodologies, to help novices become fully adept in the field. References at the end of each chapter lead to original research papers and reviews for facilitating further investigation of individual topics. Covering the state of the science and technology, Methods and Applications of Cycloaddition Reactions in Organic Syntheses enables synthetic organic chemists to advance their research and develop new functional materials and applications in chemical research, pharmaceuticals, and materials science.
Asymmetric Synthesis of Three Membered Rings
Author | : Hélène Pellissier,Alessandra Lattanzi,Renato Dalpozzo |
Publsiher | : John Wiley & Sons |
Total Pages | : 606 |
Release | : 2017-06-19 |
Genre | : Science |
ISBN | : 9783527341146 |
Download Asymmetric Synthesis of Three Membered Rings Book in PDF, Epub and Kindle
The first handbook to focus on the asymmetric synthesis of different types of three-membered rings. The outstanding and experienced authors have an excellent international reputation and cover cyclopropanes, epoxides and aziridines as well as chiral oxaziridines in equal measure. To this end, they describe in detail different synthetic approaches starting with chiral substrates as well as the application of chiral metal- or organocatalysts. Furthermore, methods for the kinetic resolution of initially racemic products are treated alongside recent advances and novel developments in established techniques for the synthesis of three-membered rings. With its structured composition this is of high interest to scientists in methodological and natural product synthesis as well as those in industrial and pharmaceutical chemistry.
Advances in Organic Synthesis
Author | : Atta-ur-Rahman,Kenneth K. Laali |
Publsiher | : Bentham Science Publishers |
Total Pages | : 594 |
Release | : 2011-01-10 |
Genre | : Science |
ISBN | : 9781608051984 |
Download Advances in Organic Synthesis Book in PDF, Epub and Kindle
"The volume focuses on recent advances in organofluorine chemistry directed towards selective fluorine introduction into various target molecules, employing both traditional and contemporary, electrophilic and nucleophilic, fluorinating agents. It brings t"
The Chemistry of Cyclobutanes 2 Volume Set
Author | : Anonim |
Publsiher | : Wiley |
Total Pages | : 0 |
Release | : 2005-04-22 |
Genre | : Science |
ISBN | : 0470864001 |
Download The Chemistry of Cyclobutanes 2 Volume Set Book in PDF, Epub and Kindle
The Chemistry of Cyclobutanes provides an in depth and comprehensive review of cyclobutanes and includes chapters on the theoretical and computational foundations; on analytical and spectroscopical aspects with dedicated chapters on Mass Spectrometry, NMR and IR/UV. There are also extensive application examples enabling the reader to collect both a theoretical and practical understanding. The Chemistry of Functional Groups Series was originally founded by Saul Patai (1918-1998) and in the 39 years of publishing has produced more than 100 volumes, providing outstanding reviews on all aspects of functional groups including analytical, physical and synthetic and applied chemistry. Saul Patai has been helped by outstanding editors, especially Zvi Rappoport who has now taken responsibility for the series to continue the tradition of producing high quality reviews with editors such as Y. Apeloig, I. Marek and J. Liebman.