Target Discovery And Validation
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Target Discovery and Validation
Author | : Alleyn T. Plowright |
Publsiher | : John Wiley & Sons |
Total Pages | : 396 |
Release | : 2020-02-18 |
Genre | : Medical |
ISBN | : 9783527345298 |
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The modern drug developers? guide for making informed choices among the diverse target identification methods Target Discovery and Validation: Methods and Strategies for Drug Discovery offers a hands-on review of the modern technologies for drug target identification and validation. With contributions from noted industry and academic experts, the book addresses the most recent chemical, biological, and computational methods. Additionally, the book highlights techologies that are applicable to ?difficult? targets and drugs directed at multiple targets, including chemoproteomics, activity-based protein profiling, pathway mapping, genome-wide association studies, and array-based profiling. Throughout, the authors highlight a range of diverse approaches, and target validation studies reveal how these methods can support academic and drug discovery scientists in their target discovery and validation research. This resource: -Offers a guide to identifying and validating targets, a key enabling technology without which no new drug development is possible -Presents the information needed for choosing the appropriate assay method from the ever-growing range of available options -Provides practical examples from recent drug development projects, e. g. in kinase inhibitor profiling Written for medicinal chemists, pharmaceutical professionals, biochemists, biotechnology professionals, and pharmaceutical chemists, Target Discovery and Validation explores the current methods for the identification and validation of drug targets in one comrpehensive volume. It also includes numerous practical examples.
Target Validation in Drug Discovery
Author | : Brian W. Metcalf,Susan Dillon |
Publsiher | : Elsevier |
Total Pages | : 296 |
Release | : 2011-04-28 |
Genre | : Medical |
ISBN | : 0080465978 |
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This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics. The next section looks at biologic drug development with in-depth discussion of lessons learned from such well-known cases as Erbitux, Herceptin, and Avastin. Additional targets known as "second generation" drugs, which can be identified when disease pathways are validated by biologics, present new possible small molecule therapeutics and serve as the focus of the final section of the book.
Target Identification and Validation in Drug Discovery
Author | : Jurgen Moll,Riccardo Colombo |
Publsiher | : Humana Press |
Total Pages | : 388 |
Release | : 2016-05-01 |
Genre | : Medical |
ISBN | : 1493962787 |
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This Methods in Molecular Biology book details current procedures for identifying and validating new drug targets. Includes methods and approaches covering biochemical, cell based, in vivo models and translational methods, as well as relevant case reports."
In Silico Technologies in Drug Target Identification and Validation
Author | : Darryl Leon,Scott Markel |
Publsiher | : CRC Press |
Total Pages | : 510 |
Release | : 2006-06-13 |
Genre | : Medical |
ISBN | : 9781420015737 |
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The pharmaceutical industry relies on numerous well-designed experiments involving high-throughput techniques and in silico approaches to analyze potential drug targets. These in silico methods are often predictive, yielding faster and less expensive analyses than traditional in vivo or in vitro procedures. In Silico Technologies in Drug Target Ide
Improving and Accelerating Therapeutic Development for Nervous System Disorders
Author | : Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders |
Publsiher | : National Academies Press |
Total Pages | : 118 |
Release | : 2014-02-06 |
Genre | : Medical |
ISBN | : 9780309292498 |
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Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.
Target Discovery and Validation Reviews and Protocols
![Target Discovery and Validation Reviews and Protocols](https://youbookinc.com/wp-content/themes/mts_schema/cover.jpg)
Author | : Mouldy Sioud |
Publsiher | : Unknown |
Total Pages | : 135 |
Release | : 2007 |
Genre | : Electronic Book |
ISBN | : OCLC:456399753 |
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Drug Target Selection and Validation
Author | : Marcus T. Scotti,Carolina L. Bellera |
Publsiher | : Springer Nature |
Total Pages | : 266 |
Release | : 2022-05-17 |
Genre | : Medical |
ISBN | : 9783030958954 |
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The first book in the newly created book series, Computer-Aided Drug Discovery and Design, focuses on the computational aspects of early drug discovery, drug target identification, and validation. It revises current classical paradigms in target and phenotypic-based drug design with still ingrained approximations and concepts and discusses the research in the new network approach concept that include kinetic selectivity and metabolic analysis. Many often-overlooked approximations and concepts in drug discovery are fully covered. Drug Target Selection and Validation includes both introductory sections and research-based sections to be of use to both students and research scientists in drug discovery, design, kinetics and metabolic analysis. Pharmaceutical scientists, pharmaceutics, drug developers, pharmacologists, biomedical researchers in computer science, medicinal chemists, and precision medicine developers benefit from the information provided. The book concludes with a chapter on chemical and structural databases.
Phenotypic Drug Discovery
Author | : Beverley Isherwood,Angelique Augustin |
Publsiher | : Royal Society of Chemistry |
Total Pages | : 273 |
Release | : 2020-12-09 |
Genre | : Medical |
ISBN | : 9781839160790 |
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Phenotypic drug discovery has been highlighted in the past decade as an important strategy in the discovery of new medical entities. How many marketed drugs are derived from phenotypic screens? From the most recent examples, what were the factors enabling target identification and validation? This book answers these questions by elaborating on fundamental capabilities required for phenotypic drug discovery and using case studies to illustrate approaches and key success factors. Written and edited by experienced practitioners from both industry and academia, this publication will equip researchers with a thought-provoking guide to the application and future development of contemporary phenotypic drug discovery for clinical success.