The Century Of The Gene

In a book that promises to change the way we think and talk about genes and genetic determinism, Evelyn Fox Keller, one of our most gifted historians and philosophers of science, provides a powerful, profound analysis of the achievements of genetics and molecular biology in the twentieth century, the century of the gene. Not just a chronicle of biology’s progress from gene to genome in one hundred years, The Century of the Gene also calls our attention to the surprising ways these advances challenge the familiar picture of the gene most of us still entertain. Keller shows us that the very successes that have stirred our imagination have also radically undermined the primacy of the gene—word and object—as the core explanatory concept of heredity and development. She argues that we need a new vocabulary that includes concepts such as robustness, fidelity, and evolvability. But more than a new vocabulary, a new awareness is absolutely crucial: that understanding the components of a system (be they individual genes, proteins, or even molecules) may tell us little about the interactions among these components. With the Human Genome Project nearing its first and most publicized goal, biologists are coming to realize that they have reached not the end of biology but the beginning of a new era. Indeed, Keller predicts that in the new century we will witness another Cambrian era, this time in new forms of biological thought rather than in new forms of biological life.

In a book that promises to change the way we think and talk about genes and genetic determinism, Evelyn Fox Keller, one of our most gifted historians and philosophers of science, provides a powerful, profound analysis of the achievements of genetics and molecular biology in the twentieth century, the century of the gene.

The #1 NEW YORK TIMES Bestseller The basis for the PBS Ken Burns Documentary The Gene: An Intimate History Now includes an excerpt from Siddhartha Mukherjee’s new book Song of the Cell! From the Pulitzer Prize–winning author of The Emperor of All Maladies—a fascinating history of the gene and “a magisterial account of how human minds have laboriously, ingeniously picked apart what makes us tick” (Elle). “Sid Mukherjee has the uncanny ability to bring together science, history, and the future in a way that is understandable and riveting, guiding us through both time and the mystery of life itself.” —Ken Burns “Dr. Siddhartha Mukherjee dazzled readers with his Pulitzer Prize-winning The Emperor of All Maladies in 2010. That achievement was evidently just a warm-up for his virtuoso performance in The Gene: An Intimate History, in which he braids science, history, and memoir into an epic with all the range and biblical thunder of Paradise Lost” (The New York Times). In this biography Mukherjee brings to life the quest to understand human heredity and its surprising influence on our lives, personalities, identities, fates, and choices. “Mukherjee expresses abstract intellectual ideas through emotional stories…[and] swaddles his medical rigor with rhapsodic tenderness, surprising vulnerability, and occasional flashes of pure poetry” (The Washington Post). Throughout, the story of Mukherjee’s own family—with its tragic and bewildering history of mental illness—reminds us of the questions that hang over our ability to translate the science of genetics from the laboratory to the real world. In riveting and dramatic prose, he describes the centuries of research and experimentation—from Aristotle and Pythagoras to Mendel and Darwin, from Boveri and Morgan to Crick, Watson and Franklin, all the way through the revolutionary twenty-first century innovators who mapped the human genome. “A fascinating and often sobering history of how humans came to understand the roles of genes in making us who we are—and what our manipulation of those genes might mean for our future” (Milwaukee Journal-Sentinel), The Gene is the revelatory and magisterial history of a scientific idea coming to life, the most crucial science of our time, intimately explained by a master. “The Gene is a book we all should read” (USA TODAY).

Covering all species from yeast to humans, this is the first book to tell the story of selfish genetic elements that act narrowly to advance their own replication at the expense of the larger organism.

This book explores two disparate sets of debates in the history and philosophy of the life sciences: the history of subjectivity in shaping objective science and the history of dominance of reductionism in molecular biology. It questions the dominant conception of the scientist-subject as a neo-Kantian ideal self – that is, the scientist as a unified and wilful, self-determined, self-regulated, active and autonomous, rational subject wilfully driven by social and scientific ethos – in favour of a narrative that shows how the microcosm of reductionism is sustained, adopted, questioned, or challenged in the creative struggles of the scientist-subject. The author covers a century-long history of the concept of the gene as a series of "pioneering moments" through an engagement with life-writings of eminent scientists to show how their ways of being and belonging relate with the making of the science. The scientist-self is theorized as fundamentally a feeling, experiencing, and suffering subject split between the conscious and unconscious and constitutive of personality aspects that are emotional/psychological, "situated" (cultural and ideological), metaphysical, intersubjective, and existential at the same time. An engaging interdisciplinary interpretation of the dominance of reductionism in genetic science, this book will be of major interest to scholars and researchers of science, history, and philosophy alike.

Though First Nations communities in Canada have historically lacked access to clean water, affordable food, and equitable healthcare, they have never lacked access to well-funded scientists seeking to study them. The Science of Settler Colonialism examines the relationship between science and settler colonialism through the lens of "Aboriginal diabetes" and the thrifty gene hypothesis, which posits that Indigenous peoples are genetically predisposed to type-II diabetes and obesity due to their alleged hunter-gatherer genes. Hay's study begins with Charles Darwin's travels and his observations on the Indigenous peoples he encountered to set the context for Canadian histories of medicine and colonialism, which are rooted in Victorian science and empire. It continues in the mid-twentieth century with a look at nutritional experimentation during the long career of Percy Moore, the medical director of Indian Affairs (1946-1965). Hay then turns to James Neel's invention of the thrifty gene hypothesis in 1962 and Robert Hegele's reinvention and application of the hypothesis to Sandy Lake First Nation in northern Ontario in the 1990s. Finally, Hay demonstrates the way in which settler colonial science was responded to and resisted by Indigenous leadership in Sandy Lake First Nation, who used monies from the thrifty gene study to fund wellness programs in their community. The Science of Settler Colonialism exposes the exploitative nature of settler science with Indigenous subjects, the flawed scientific theories stemming from faulty assumptions of Indigenous decline and disappearance, as well as the severe inequities in Canadian healthcare that persist even today.

The Meanings of the Gene is a compelling look at societal hopes and fears about genetics in the course of the twentieth century. The work of scientists and doctors in advancing genetic research and its applications has been accompanied by plenty of discussion in the popular press—from Good Housekeeping and Forbes to Ms. and the Congressional Record—about such topics as eugenics, sterilization, DNA, genetic counseling, and sex selection. By demonstrating the role of rhetoric and ideology in public discussions about genetics, Condit raises the controversial question, Who shapes decisions about genetic research and its consequences for humans—scientists, or the public? Analyzing hundreds of stories from American magazines—and, later, television news—from the 1910s to the 1990s, Condit identifies three central and enduring public worries about genetics: that genes are deterministic arbiters of human fate; that genetics research can be used for discriminatory ends; and that advances in genetics encourage perfectionistic thinking about our children. Other key public concerns that Condit highlights are the complexity of genetic decision-making and potential for invasion of privacy; conflict over the human genetic code and experimentation with DNA; and family genetics and reproductive decisions. Her analysis reveals a persistent debate in the popular media between themes of genetic determinism (such as eugenics) and more egalitarian views that place genes within the complexity of biological and social life. The Meanings of the Gene offers an insightful view of our continuing efforts to grapple with our biological natures and to define what it means, and will mean in the future, to be human.