The Methuselah Enzyme

In The Methuselah Gene, Michael S. Maurer’s mesmerizing medical thriller, Alex Morton, a talented but unorthodox scientist, undertakes the care of little Jimmy Higgins who suffers from one of the rarest diseases in the world, progeria, a genetic mutation that grossly accelerates the aging process. Alex’s study of progeria yields staggering discoveries about the mother of all diseases, aging. What Alex does not know is that Mother Nature jealously guards her secrets and that his newly developed therapies will lead to calamitous unintended consequences.

MUST WE AGE? A long life in a healthy, vigorous, youthful body has always been one of humanity's greatest dreams. Recent progress in genetic manipulations and calorie-restricted diets in laboratory animals hold forth the promise that someday science will enable us to exert total control over our own biological aging. Nearly all scientists who study the biology of aging agree that we will someday be able to substantially slow down the aging process, extending our productive, youthful lives. Dr. Aubrey de Grey is perhaps the most bullish of all such researchers. As has been reported in media outlets ranging from 60 Minutes to The New York Times, Dr. de Grey believes that the key biomedical technology required to eliminate aging-derived debilitation and death entirely—technology that would not only slow but periodically reverse age-related physiological decay, leaving us biologically young into an indefinite future—is now within reach. In Ending Aging, Dr. de Grey and his research assistant Michael Rae describe the details of this biotechnology. They explain that the aging of the human body, just like the aging of man-made machines, results from an accumulation of various types of damage. As with man-made machines, this damage can periodically be repaired, leading to indefinite extension of the machine's fully functional lifetime, just as is routinely done with classic cars. We already know what types of damage accumulate in the human body, and we are moving rapidly toward the comprehensive development of technologies to remove that damage. By demystifying aging and its postponement for the nonspecialist reader, de Grey and Rae systematically dismantle the fatalist presumption that aging will forever defeat the efforts of medical science.

Methuselah Flies presents a trailblazing project on the biology of aging. It describes research on the first organisms to have their lifespan increased, and their aging slowed, by hereditary manipulation. These organisms are fruit flies from the species Drosophila melanogaster, the great workhorse of genetics. Michael Rose and his colleagues have been able to double the lifespan of these insects, and improved their health in numerous respects as well. The study of these flies with postponed aging is one of the best means we have of understanding, and ultimately achieving, the postponement of aging in humans. As such, the carefully presented detail of this book will be of value to research devoted to the understanding and control of aging.Methuselah Flies: ? is a tightly edited distillation of twenty years of work by many scientists? contains the original publications regarding the longer-lived fruit flies? offers commentaries on each of the topics covered ? new, short essays that put the individual research papers in a wider context? gives full access to the original data ? captures the scientific significance of postponed aging for a wide academic audienc

In the year 2044, scientists have revealed new advances to extend the longevity of human life. Within the next years the world's population explodes by more than one billion people each year. Though millions live already deep under the moon's surface, it becomes necessary to search for planets outside our solar system. Tim Turner, a teacher and scientist, tackles this mission by traveling to the sun's next star, Alpha Centauri. The isolation of his task drives him to the edge of lunacy, but what he discovers could prevent the human race from destroying itself. When Turner returns to Earth thirty-six years later, he comes back to an unthinkable situation. What has happened during his absence-and what has become of the two women he loves most? A tantalizing mix of science fiction and love story, Dangerous Voyage to Alpha Centauri poses a fascinating question: Could this plot become a reality for the Earth and its residents in the not-so-distant future?