The Molecular Foundations Of Psychiatry

This text offers a comprehensive introduction to molecular biology, genetics, and neurobiology relevant to psychiatry. Generously illustrated chapters are organized to be read at both an introductory and a more advanced level. Both beginners and advanced professionals will benefit from this text's discussion of how psychotropic drugs work and how gene-environment interactions may contribute to the pathogenesis of psychiatric disorders. The authors demonstrate how molecular investigations in psychiatry will revolutionize the field by leading to improved diagnostic testing, to new and more effective treatments, and ultimately to the development of preventive measures for mental illness.

Rosenberg’s Molecular and Genetic Basis of Neurologic and Psychiatric Disease, Sixth Edition: Volume Two provides a comprehensive introduction and reference to the foundations and practical aspects relevant to the majority of neurologic and psychiatric disease. This updated volume focuses on degenerative disorders, movement disorders, neuro-oncology, neurocutaneous disorders, epilepsy, white matter diseases, neuropathies and neuronopathies, muscle and neuromuscular junction disorders, stroke, psychiatric disease, and a neurologic gene map. A favorite of over three generations of students, clinicians and scholars, this new edition retains and expands on the informative, concise and critical tone of the first edition. This is an essential reference for general medical practitioners, neurologists, psychiatrists, geneticists, related professionals, and for the neuroscience and neurology research community at large. The content covers all aspects essential to the practice of neurogenetics to inform clinical diagnosis, treatment and genetic counseling. Provides comprehensive coverage on the neurogenetic foundation of neurological and psychiatric disease Presents detailed coverage of genomics, animal models and diagnostic methods, with new coverage on evaluating patients with biochemical abnormalities or gene mutations Includes new chapters on the pharmacogenomics of epilepsy and the most recent updates in molecular genetics, focusing on neurodegenerative and psychiatric diseases

Treating stroke requires attention not only to patients’ physical needs, but to their psychiatric needs as well. Unfortunately, there has been a considerable lack of literature that tackles this important facet of recovery. The Psychiatry of Stroke fills this void through a comprehensive examination that explores the mental and physical issues faced by stroke patients and offers up-to-date treatment options. Based on extensive clinical experience, the text offers practical advice for improving the treatment of stroke by increasing the attention paid to its mental aspects. Detailed and definitive, this unique text demonstrates how mental impairment sets limits to stroke treatment and rehabilitation and shows how to evaluate and treat these impairments. Accessible to a wide range of readers, this new edition presents detailed reviews of classical papers as well as more basic outlines that provide a general overview. Regardless of familiarity, readers will find comprehensive and authoritative guidance for improving treatment. Some of the topics covered include: background and causation risk factors and diagnosis of stroke localization of mental functions neuropsychopharmachology psychiatric syndromes apathy and failure to rehabilitate depression, anxiety, and dementia sex anger and violence outcome and effects the process of recovery family treatment team legal issues, money, and ethics and much more! The Psychiatry of Stroke also includes a wealth of informative tables and diagrams as well as a full glossary of terms. Extensively referenced, this important text also provides useful appendices that look at resources for caregivers and the anatomy and historical significance of stroke. Physicians and mental health professionals who treat stroke patients; staff of stroke units and rehabilitation hospitals and centers; fellows in geriatric psychiatry, geriatrics, and stroke programs; gerontology students and educators; and families of the victims of stroke or vascular dementia will find this book an invaluable day-to-day resource.

Core Readings in Psychiatry, Second Edition, stands as an essential text for the academic. The contributors are distinguished experts who have a firm grasp of the relevant and classical citations in specific areas of psychiatry. In the intervening 8 years since the first edition, the profession's knowledge base has changed immensely. Included in this second edition are numerous citations and new topics such as AIDS, neuropsychiatry, models of psychoanalytic thought, child development, and medical economics. The book will open bibliographic doors for the academician as well as for the provider, manager, and consumer of psychiatric services and knowledge. It is designed to be an introduction and guide to the entire psychiatric literature.

The book highlights important aspects of Molecular Psychiatry, including molecular mechanisms, animal models, biomarkers, advanced methods, drugs and antidepressant response, as well as genetics and epigenetics. Molecular mechanisms are a vital part of the search for the biological basis of psychiatric disorders, providing molecular hints that can later be tested as biomarkers or targets for drug development. Animal models represent a commonly used approach to aid in this bench-to-bed translation; the examples here are social defeat stress and the Roman High-Avoidance (RHA) and the Roman Low-Avoidance (RLA) rats. For biomarkers, psychiatric disorders pose a particular challenge due to the tissue specificity of many currently investigated biomarkers; i.e., not all blood-based measures directly represent changes in the brain. The Ebook includes five articles focused on the challenges of identifying clinically and biologically relevant biomarkers for psychiatric disorders. Scientific progress typically is fostered by the development of new methods. The application of machine learning methods for the proper analysis of Big Data and induced pluripotent stem cells are examples outlined in this Ebook. Furthermore, three articles are devoted to the understanding of the mechanisms of actions of existing drugs with the ultimate goal of identifying ways to predict treatment response in patients. Finally, three articles deepen the insight into the genetics and epigenetics of psychiatric disorders.

Convenient, practical, and portable Revised and updated, the second edition of this practical resource remains the only advanced practice guide to provide an overview of the major DSM-5 disorders across the lifespan and complete clinical guidelines for their psychopharmacologic management. Compiled by expert practitioners in psychiatric care and pharmacy, it is designed specifically for use by nurse practitioners and other primary caregivers in clinical practice. Organized for quick access to key information, the resource includes the clinical features of each disorder and symptoms and information about the most current and effective drugs for its management. Tables delineate the first and second lines of drug therapy along with adjunctive therapies for each disorder. Drugs are organized according to classification and include the essential information needed to safely prescribe and monitor a patient’s response to a particular drug. Brand and generic names, drug class, customary dosage, side effects, drug interactions, pharmacokinetics, precautions, and management of special populations are also addressed. Convenient, practical, and portable, this guide will be a welcome and frequently used resource. Key Features: Delivers psychopharmacological treatment guidelines for major DSM-5 disorders and parameters for drug use Prioritizes drugs according to their clinical efficacy and recommended treatment algorithms Includes brand and generic names, dosages, side effects, drug interactions, pharmacokinetics, precautions, and management of special populations Provides easy-to-read tables for quick clinical consultation Offers information on clinical algorithms, lab evaluation, and preventive services Addresses medical and legal pitfalls

In an era where scientific advances frequently make even the most recent scientific or medical journal articles dated soon after their publication, it is more crucial than ever for practitioners to be able to effectively evaluate new information. Using the millennium as a benchmark for surveying progress in the field, this indispensable volume captures the current state of the discipline and considers its future evolution. Key chapters by some of the field's most respected practitioners consider the impact of changing conceptual, organizational, and philosophical issues, as well as of neuroscience research findings, on the shape of the discipline. The current and future relevance of psychoanalysis; the role of social psychiatry as translator and bridge between the worlds of treatment, practice, and public policy; and the need for a new multiaxial diagnostic system that addresses motive and meaning as well as the biological and genetic contributions to behavior are just a few of the issues explored. Other chapters consider the role of genetics and molecular biology in research on mental illness; the potential uses of functional brain imaging in clinical practice; a clinical model for selecting psychotherapy and/or pharmacotherapy; and the challenge of developing research methods for assessing treatment effectiveness. Also examined are issues such as practice guidelines, managed care and the financing of mental health treatment, and the ethical conduct of the psychiatrist. The book's final chapters survey the psychiatric workforce of today and tomorrow, including its composition and education, and, finally, offer predictions about psychiatry in the next century. In Psychiatry in the New Millennium, psychiatrists and residents alike will find information vital to their understanding of both this century's psychiatric foundations and the next century's new discoveries.

This book provides the reader with expert guidance on how to prevent, detect and manage the 'organic' psychiatric disorders experienced by people with cancer. Containing 13 chapters on topics from 'Surgery and Radiotherapy', and 'Hormone and Cytokine treatments' to 'Clinical Psychiatric Assessment of Patients with Cancer' this unique resource offers readers with fully up-to-date and high-quality information on how to enhance the quality of life for patients living with, and beyond cancer.--