The Nervous Knight

Once upon a time, in a peaceful kingdom far away, there lived a knight (in training). This knight was never ever seen without their armour. In fact, nobody even knew what they looked like under their helmet. Why would they remove their armour? You never know what might happen. What if there was suddenly a war, or an exploding volcano, or they fell and scraped their knee?! The Nervous Knight shows what childhood anxiety can look like, while helping to normalise it and show children that they can do the things they care about despite their worries. It also contains a guide for parents and professionals, giving expert advice on how to use the book to aid discussions on this topic.

In a land of ever-flowing streams, where sunlight falls with golden beams, there lives a knight in the kingdom of frogs, Sir Hoppity of the castle Log. He must now leave upon his quest, and with him comes the sweet princess. Down bendy roads with shadowed bends, will they ever make it back again?

In the first 20 years that followed the purinergic signalling hypothesis in 1972, most scientists were sceptical about its validity, largely because ATP was so well established as an intracellular molecule involved in cell biochemistry and it seemed unlikely that such a ubiquitous molecule would act as an extracellular signalling molecule. However, after the receptors for ATP and adenosine were cloned and characterized in the early 1990s and ATP was established as a synaptic transmitter in the brain and sympathetic ganglia, the tide turned. More recently it has become clear that ATP is involved in long-term (trophic) signalling in cell proliferation, differentiation and death, in development and regeneration, as well as in short-term signalling in neurotransmission and secretion. Also, important papers have been published showing the molecular structure of P2X receptors in primitive animals like Amoeba and Schistosoma, as well as green algae. This has led to the recognition of the widespread nature of the purinergic signalling system in most cell types and to a rapid expansion of the field, including studies of the pathophysiology as well as physiology and exploration of the therapeutic potential of purinergic agents. In two books, Geoffrey Burnstock and Alexej Verkhratsky have aimed at drawing together the massive and diverse body of literature on purinergic signalling. The topic of this first book is purinergic signalling in the peripheral and central nervous systems and in the individual senses. In a second book the authors focus on purinergic signalling in non-excitable cells, including those of the airways, kidney, pancreas, endocrine glands and blood vessels. Diseases related to these systems are also considered.

From a "New York Times"-bestselling author and today's most admired storyteller, here is an unforgettable tale of a most miraculous love affair: a meeting of passion, wit, and true romance between a thoroughly modern woman--and a man who lived 400 years before.

This volume of the Handbook of Zoology summarizes "small" groups of animals across the animal kingdom. Dicyemida and Orthonectida are enigmatic parasites, formerly united as "Mesozoa" and their position among the multicellular animals is still not known with certainty. Placozoa are small, flat marine animals which provide important information on metazoan evolution. Comb jellies (Ctenophora) are esthetically fascinating animals which cause considerable discussion about their phylogenetic position. Seisonida are closely related to rotifers and acanthocephalans. Cycliophora were discovered and described as one of the last higher taxa and surprise by their complex life cycle. Kamptozoa (= Entoprocta) are small sessile animals in the sea and sometimes also in freshwater. Arrow worms (Chaetognatha) play an important role as predators in the plankton, but they also include benthic forms. Pterobranchia and acorn worms (Enteropneusta) belong to the deuterostomia and are related to echinoderms. In particular enteropneusts play an important role in understanding deuterostome evolution. These chapters provide up to date reviews of these exiting groups with reference to the important literature and therefore serves as an important source of information.

Bronze Medal Winner in the Picture Books, Early Reader category of the 2015 Foreword Reviews' INDIEFAB Book of the Year Awards Once upon a time there was a Princess. She had everything a little girl could ever want, and she was happy. That is, until the fog came... The Princess and the Fog is picture book to help sufferers of depression aged 5-7 cope with their difficult feelings. It uses vibrant illustrations, a sense of humour and metaphor to create a relatable, enjoyable story that describes the symptoms of childhood depression while also providing hope that things can get better with a little help and support. The story is also a great starting point for explaining depression to all children, especially those who may have a parent or close family member with depression. With an essential guide for parents and carers by clinical paediatric psychologists, Dr Melinda Edwards MBE and Linda Bayliss, this book will be of immeasurable value to anyone supporting a child with, or affected by, depression, including social workers, psychologists, psychiatrists, counsellors, arts therapists, pastoral care workers and school staff, as well as parents and carers.