The Restless Cell

An essential introduction to the physics of active matter and its application to questions in biology In recent decades, the theory of active matter has emerged as a powerful tool for exploring the differences between living and nonliving states of matter. The Restless Cell provides a self-contained, quantitative description of how the continuum theory of matter has been generalized to account for the complex and sometimes counterintuitive behaviors of living materials. Christina Hueschen and Rob Phillips begin by illustrating how classical field theory has been used by physicists to describe the transport of matter by diffusion, the elastic deformations of solids, and the flow of fluids. Drawing on physical insights from the study of diffusion, they introduce readers to the continuum theory protocol—a step-by-step framework for developing equations that describe matter as a continuum—and show how these methods and concepts can be generalized to the study of living, energy-consuming matter. Hueschen and Phillips then present a range of engaging biological case studies across scales, such as the symmetry breaking that occurs in developing embryos, the perpetual flows that take place in giant algal cells, and the herding of wildebeest on the plains of the Serengeti. An essential resource for students and researchers in biological physics and quantitative biology, The Restless Cell gives complete derivations of all calculations and features illustrations by Nigel Orme that seamlessly bridge conceptual models and continuum descriptions of living matter.

An essential introduction to the physics of active matter and its application to questions in biology In recent decades, the theory of active matter has emerged as a powerful tool for exploring the differences between living and nonliving states of matter. The Restless Cell provides a self-contained, quantitative description of how the continuum theory of matter has been generalized to account for the complex and sometimes counterintuitive behaviors of living materials. Christina Hueschen and Rob Phillips begin by illustrating how classical field theory has been used by physicists to describe the transport of matter by diffusion, the elastic deformations of solids, and the flow of fluids. Drawing on physical insights from the study of diffusion, they introduce readers to the continuum theory protocol—a step-by-step framework for developing equations that describe matter as a continuum—and show how these methods and concepts can be generalized to the study of living, energy-consuming matter. Hueschen and Phillips then present a range of engaging biological case studies across scales, such as the symmetry breaking that occurs in developing embryos, the perpetual flows that take place in giant algal cells, and the herding of wildebeest on the plains of the Serengeti. An essential resource for students and researchers in biological physics and quantitative biology, The Restless Cell gives complete derivations of all calculations and features illustrations by Nigel Orme that seamlessly bridge conceptual models and continuum descriptions of living matter.

From Pulitzer Prize-winning and #1 New York Times bestselling author of The Emperor of All Maladies and The Gene, The Song of The Cell is the third book in this extraordinary writer's exploration of what it means to be human-rich with Siddhartha Mukherjee's revelatory and exhilarating stories of scientists, doctors, and all the patients whose lives may be saved by their work. In the late 1600s, a distinguished English polymath, Robert Hooke, and an eccentric Dutch cloth merchant, Antonie van Leeuwenhoek, look down their handmade microscopes. What they see introduces a radical concept that sweeps through biology and medicine, touching virtually every aspect of the two sciences and altering both forever. It is the fact that complex living organisms are assemblages of tiny, self-contained, self-regulating units. Our organs, our physiology, our selves-hearts, blood, brains-are built from these compartments. Hooke christens them 'cells'. The discovery of cells-and the reframing of the human body as a cellular ecosystem-announced the birth of a new kind of medicine based on the therapeutic manipulations of cells. A hip fracture, a cardiac arrest, Alzheimer's, dementia, AIDS, pneumonia, lung cancer, kidney failure, arthritis, COVID-all could be viewed as the results of cells, or systems of cells, functioning abnormally. And all could be perceived as loci of cellular therapies. In The Song of the Cell, Mukherjee tells the story of how scientists discovered cells, began to understand them, and are now using that knowledge to create new humans. He seduces readers with writing so vivid, lucid, and suspenseful that complex science becomes thrilling. Told in six parts, laced with Mukherjee's own experience as a researcher, doctor, and prolific reader, The Song of the Cell is both panoramic and intimate-a masterpiece.

Plants, so predictable, stay where they are. And yet, like all living things, they also move: they grow, adapt, shed leaves and bark, spread roots and branches, snare pollinators, and reward cultivators. This book, the first to thoroughly explore the subject since Darwin’s 1881 treatise on movements in plants, is a comprehensive, up-to-date account of the mechanisms and the adaptive values that move plants. Drawing on examples across the spectrum of plant families—including mosses, ferns, conifers, and flowering plants—the author opens a window on how plants move: within cells, as individual cells, and via organs. Opening with an explanation of how cellular motors work and how cells manage to move organs, Dov Koller considers the movement of roots, tubers, rhizomes, and other plant parts underground, as well as the more familiar stems, leaves, and flowers. Throughout, Koller presents information at the subcellular and cellular levels, including the roles of receptors, signaling pathways, hormones, and physiological responses in motor function. He also discusses the adaptive significance of movements. His book exposes the workings of a world little understood and often overlooked, the world of restless plants and the movements by which they accomplish the necessary functions of their lives.

A “wide-ranging, witty, and astonishingly learned” scientific and cultural history of the concept of the capacity to act in nature (London Review of Books). Today, a scientific explanation is not meant to ascribe agency to natural phenomena: we would not say a rock falls because it seeks the center of the earth. Even for living things, in the natural sciences and often in the social sciences, the same is true. A modern botanist would not say that plants pursue sunlight. This has not always been the case, nor, perhaps, was it inevitable. Since the seventeenth century, many thinkers have made agency, in various forms, central to science. The Restless Clock examines the history of this principle, banning agency, in the life sciences. It also tells the story of dissenters embracing the opposite idea: that agency is essential to nature. The story begins with the automata of early modern Europe, as models for the new science of living things, and traces questions of science and agency through Descartes, Leibniz, Lamarck, and Darwin, among many others. Mechanist science, Jessica Riskin shows, had an associated theology: the argument from design, which found evidence for a designer in the mechanisms of nature. Rejecting such appeals to a supernatural God, the dissenters sought to naturalize agency rather than outsourcing it to a “divine engineer.” Their model cast living things not as passive but as active, self-making machines. The conflict between passive- and active-mechanist approaches maintains a subterranean life in current science, shaping debates in fields such as evolutionary biology, cognitive science, and artificial intelligence. This history promises not only to inform such debates, but also our sense of the possibilities for what it means to engage in science—and even what it means to be alive. Praise for The Restless Clock “A wonderful contribution—and much needed corrective—to the history of European ideas about life and matter.” —Evelyn Fox Keller, author of The Mirage of a Space between Nature and Nurture “Engrossing and illuminating.” —Nature “A sweeping survey of the search for answers to the mystery of life. Riskin writes with clarity and wit, and the breadth of her scholarship is breathtaking.” —Times Higher Education (UK)

In more than four decades as president of The Land Institute, Wes Jackson became widely known as one of the founders of the sustainable agriculture movement for his work on perennial grains and Natural Systems Agriculture. But Jackson’s contribution to contemporary intellectual and political life goes well beyond plant breeding. Ever since he created one of the first university environmental studies programs in the early 1970s, Jackson has been exploring the human predicaments around sustainability and justice, asking questions that pull not only on agriculture and ecology but also on politics, economics, and culture. That work has appeared in four sole-authored books by Jackson, but nowhere is there an accessible summary of his key ideas. Robert Jensen provides a short, elegant introduction to Jackson’s ideas on ways to provide humanity with a truly sustainable foundation in grain agriculture, presented in a way that connects to the growing concern about climate change and other ecological crises. Jackson’s strength has been in generating new ideas and pushing the envelope not only on sustainable agriculture but also on the other dramatic changes necessary if we are to create a sustainable and just society. This volume helps the reader to organize those exciting ideas in a way that can expand the horizons of students and lay readers as well as challenge specialists in these fields. In a time when critical thinking and clear understanding are desperately needed if we are to face the multiple, cascading ecological and social crises, The Restless and Relentless Mind of Wes Jackson presents Jackson’s crucial insights about the natural world and human societies that can help provide a framework for understanding the tough decisions we will have to make. But just as important is the book’s glimpse into the curiosity that drives Jackson and the creativity that distinguishes his intellectual and activist work.

#1 NEW YORK TIMES BESTSELLER “History matters to McCain, and for him America is and was about its promise. The book is his farewell address, a mixture of the personal and the political. ‘I have loved my life,’ he writes. ‘All of it.’ The Restless Wave is a fitting valedictory for a man who seldom backed down.” —The Guardian (US) “A book-length meditation on what it means to face the hard challenges of long life and the sobering likelihood of imminent death…A reflection on hardship, a homily on purpose, a celebration of life — and a challenge to Americans to live up to their values and founding principles at a time when both are in jeopardy.” —The Boston Globe In this candid political memoir from Senator John McCain, an American hero reflects on his life and what matters most. “I don’t know how much longer I’ll be here. Maybe I’ll have another five years…Maybe I’ll be gone before you read this. My predicament is, well, rather unpredictable. But I’m prepared for either contingency, or at least I’m getting prepared. I have some things I’d like to take care of first, some work that needs finishing, and some people I need to see. And I want to talk to my fellow Americans a little more if I may.” So writes John McCain in this inspiring, moving, frank, and deeply personal memoir. Written while confronting a mortal illness, McCain looks back with appreciation on his years in the Senate, his historic 2008 campaign for the presidency against Barack Obama, and his crusades on behalf of democracy and human rights in Eastern Europe and the Middle East. Always the fighter, McCain attacks the spurious nationalism and political polarization afflicting American policy. He makes an impassioned case for democratic internationalism and bi-partisanship. He recalls his disagreements with several presidents, and minces no words in his objections to some of President Trump's statements and policies. At the same time, he tells stories of his most satisfying moments of public service and offers a positive vision of America that looks beyond the Trump presidency. The Restless Wave is John McCain at his best.