The Science Of Why Volume 4

"An illustrated, popular science reader for any age."--

Back by popular demand: a brand-new volume of science queries, quirks, and quandaries in the mega-bestselling Science of Why series, sure to enlighten and entertain readers of all ages. Have you ever wondered why we close our eyes when we sneeze? Or how far underground things can live? Or if there’s a way to choose the fastest lineup at the grocery store? Yes? Then fasten your seat belts! Bestselling author Jay Ingram is here to take you on a rollercoaster ride through science’s most perplexing puzzles. From the age-old mysteries that have fascinated us to the pressing unknowns about our future and all the everyday wonderings in-between, Jay answers questions that confound and dumbfound, such as: Why do zebras have stripes? How many universes might there be? Can we live for 200 years? ...along with everything you ever wanted to know about alien civilizations, photographic memories, nanobots, poop, and (conveniently) toilet paper. Bursting with laugh-out-loud illustrations, jaw-dropping marvels, and head-scratching science fictions, The Science of Why, Volume 4 will give readers of all stripes a real thrill.

A comprehensive and authoritative guide to developments in life and earth sciences since 1800.

A complete reference to the fields of psychology and behavioral science Volume 4 is the final volume in The Corsini Encyclopedia of Psychology and Behavioral Science series. Providing psychologists, teachers, researchers, and students with complete reference for over 1,200 topics across four volumes, this resource in invaluable for both clinical and research settings. Coverage includes conditions, assessments, scales, diagnoses, treatments, and more, including biographies on psychologists of note and psychological organizations from across the globe. The Third Edition has been updated to reflect the growing impact of neuroscience and biomedical research, providing a highly relevant reference for the highest standard of care.

From Hugo Award-winning editor Neil Clarke, the best science fiction stories of the year are collected in a single paperback volume. Keeping up-to-date with the most buzzworthy and cutting-edge science fiction requires sifting through countless magazines, e-zines, websites, blogs, original anthologies, single-author collections, and more―a task accomplishable by only the most determined and voracious readers. For everyone else, Night Shade Books is proud to introduce the latest volume of The Best Science Fiction of the Year, a yearly anthology compiled by Hugo and World Fantasy Award–winning editor Neil Clarke, collecting the finest that the genre has to offer, from the biggest names in the field to the most exciting new writers. The best science fiction scrutinizes our culture and politics, examines the limits of the human condition, and zooms across galaxies at faster-than-light speeds, moving from the very near future to the far-flung worlds of tomorrow in the space of a single sentence. Clarke, publisher and editor-in-chief of the acclaimed and award-winning magazine Clarkesworld, has selected the short science fiction (and only science fiction) best representing the previous year’s writing, showcasing the talent, variety, and awesome “sensawunda” that the genre has to offer.

Now in Paperback! Take science to a whole new level. Created in partnership with Prentice Hall, the Big Idea Science Book is a comprehensive guide to key topics in science falling into four major strands (Living Things, Earth Science, Chemistry, and Physics), with a unique difference — a website component with 200 specially created digital assets that provide the opportunity for hands-on, interactive learning.

Provides unique insider insight into the current drug development process, and what it takes to achieve success In this fourth volume in the series, inventors and primary developers of drugs that made it to the market continue telling the story of the drugs? discovery and development, and discuss the sometimes twisted route from the first drug candidate molecule to the final marketed one. Beginning with a general section addressing overarching topics for drug discovery, the book offers seven chapters that feature selected case studies describing recently introduced drugs or drug classes. These include small molecule drugs as well as biopharmaceuticals and range across different therapeutic fields. Together, they provide a representative cross-section of the present-day drug development effort. Successful Drug Discovery: Volume 4 covers trends in peptide-based drug discovery and the physicochemical properties of recently approved oral drugs. The section on drug class studies looks at antibody-drug conjugates and the discovery, evolution, and therapeutic potential of dopamine partial agonists. Featured case studies examine the discovery of Etelcalcetide for the treatment of secondary hyper-parathyroidism in patients with chronic kidney disease; the development of Lenvatinib Mesylate; the discovery and development of Venetoclax; and more. -Focuses on recently introduced drugs that have not been featured in any textbooks or general references, including Ocrelizumab, a new generation of anti-CD-20 mAb for the treatment of multiple sclerosis, and Venetoclax, a selective antagonist of BCL-2 -Features personal experiences of successful drug developers from industry and academia -Endorsed and supported by the International Union of Pure and Applied Chemistry (IUPAC) Successful Drug Discovery: Volume 4 provides a fascinating and informative look into the process of drug discovery and would be a great reference for those in the pharmaceutical industry, organic and pharmaceutical chemists, and lecturers in pharmacy.