The Thermodynamic Machinery Of Life

Thermodynamics was created in the ?rst half of the 19th century as a theory designed to explain the functioning of heat engines converting heat into mechanical work. In the course of time, while the scope of research in this ?eld was being extended to a wider and wider class of energy transformations, thermodynamics came to be considered as a general theory of machines identi?ed with energy transducers. Imp- tant progress in biochemistry in the ?rst half of the 20th century, and in molecular biology in the second half, made it possible to think of treating even living organisms as machines, at least on the subcellular level. However, success in applying thermodynamics to elucidate the phenomenon of life has been rather mitigated. Two reasons seem to be responsible for this unsatisfactory s- uation. Nineteenth century thermodynamics dealt only with simple (homogeneous) systems in complete equilibrium. Although during the 20th century a nonequilibrium thermodynamics was developed, sta- ing with the Onsager theory of linear response and ending with the Prigogine nonlinear theory of dissipative structures, these theories still concern the originally homogeneous systems. Because living organisms are complex systems with a historically frozen spatial and functional structure, a thermodynamics of both nonequilibrium and complex s- tems is needed for their description. The ?rst goal of the present book is to formulate the foundations of such a thermodynamics.

Life is an enduring mystery. Yet, science tells us that living beings are merely sophisticated structures of lifeless molecules. If this view is correct, where do the seemingly purposeful motions of cells and organisms originate? In Life's Ratchet, physicist Peter M. Hoffmann locates the answer to this age-old question at the nanoscale. Below the calm, ordered exterior of a living organism lies microscopic chaos, or what Hoffmann calls the molecular storm -- specialized molecules immersed in a whirlwind of colliding water molecules. Our cells are filled with molecular machines, which, like tiny ratchets, transform random motion into ordered activity, and create the "purpose" that is the hallmark of life. Tiny electrical motors turn electrical voltage into motion, nanoscale factories custom-build other molecular machines, and mechanical machines twist, untwist, separate and package strands of DNA. The cell is like a city -- an unfathomable, complex collection of molecular workers working together to create something greater than themselves. Life, Hoffman argues, emerges from the random motions of atoms filtered through these sophisticated structures of our evolved machinery. We are agglomerations of interacting nanoscale machines more amazing than anything in science fiction. Rather than relying on some mysterious "life force" to drive them -- as people believed for centuries -- life's ratchets harness instead the second law of thermodynamics and the disorder of the molecular storm. Grounded in Hoffmann's own cutting-edge research, Life's Ratchet reveals the incredible findings of modern nanotechnology to tell the story of how the noisy world of atoms gives rise to life itself.

An accessible introduction to thermodynamics for undergraduate biology and biochemistry students.

Volume two begins with Goethe's theories of affinities, i.e. the chemical reaction view of human life in 1809. This is followed by the history of how the thermodynamic (1876) and quantum (1905) revolutions modernized chemistry such that affinity (the 'force' of reaction) is now viewed as a function of thermodynamic 'free energy' (reaction spontaneity) and quantum 'valency' (bond stabilities). The composition, energetic state, dynamics, and evolution of the human chemical bond A?B is the centerpiece of this process. The human bond is what gives (yields) and takes (absorbs) energy in life. The coupling of this bond energy, driven by periodic inputs of solar photons, thus triggering activation energies and entropies, connected to the dynamical work of life, is what quantifies the human reaction process. This is followed by topics including mental crystallization, template theory, LGBT chemistry, chemical potential, Le Chatelier's principle, Muller dispersion forces, and human thermodynamics.

An accessible book for graduate students and researchers that describes how the laws of thermodynamics apply to Earth system processes.

Written by a wide range of experts, this work presents cosmological, biological and philosophical perspectives on complexity in our universe.

This volume is part of collection of contributions devoted to analytical and experimental techniques of dynamical systems, presented at the 15th International Conference “Dynamical Systems: Theory and Applications”, held in Łódź, Poland on December 2-5, 2019. The wide selection of material has been divided into three volumes, each focusing on a different field of applications of dynamical systems. The broadly outlined focus of both the conference and these books includes bifurcations and chaos in dynamical systems, asymptotic methods in nonlinear dynamics, dynamics in life sciences and bioengineering, original numerical methods of vibration analysis, control in dynamical systems, optimization problems in applied sciences, stability of dynamical systems, experimental and industrial studies, vibrations of lumped and continuous systems, non-smooth systems, engineering systems and differential equations, mathematical approaches to dynamical systems, and mechatronics.