The Vulnerable Plaque

Since publication of the First Edition, advances in the diagnosis and prevention and treatment strategies of the vulnerable plaque have necessitated this greatly expanded second edition. With several new chapters covering mainly diagnostic and treatment options, The Handbook of the Vulnerable Plaque will remain the benchmark text for all interventional cardiologists treating vulnerable patients by providing the physician with comprehensive insight into the world of the vulnerable plaque.

Since publication of the First Edition, advances in the diagnosis and prevention and treatment strategies of the vulnerable plaque have necessitated this greatly expanded second edition. With several new chapters covering mainly diagnostic and treatment options, The Handbook of the Vulnerable Plaque will remain the benchmark text for all interventi

New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.

Vulnerable plaque development is the result of a complex series of molecular and cellular events involving inflammation, apoptosis, rupture, and thrombosis. A detailed understanding of the mechanisms underlying the development of high-risk plaques, along with the ability to visualize and diagnose these vulnerable lesions, will lead to the effective management of acute coronary syndromes. High-Risk Atherosclerotic Plaques: Mechanisms, Imaging, Models, and Therapy brings together timely, in-depth reviews by renowned international cardiologists and scientists. Chapters cover the definition, structure, and cellular and molecular mechanisms of high risk plaque development, as well as animal models of vulnerable plaque, plaque imaging, and current and future therapies. Medical experts discuss intravascular ultrasound, optimal coherence tomography, magnetic resonance imaging, and coronary thermography. The final chapter reviews both current and future local and systematic strategies for the therapeutic management of vulnerable plaque. Exploring all aspects of this primary cause of acute coronary syndromes, this informative book updates our knowledge on the detection and treatment of vulnerable plaques. It is a valuable resource that can greatly advance the progress in treatment and prevention.

Finally, a convenient, one-volume summary of current knowledge on an area of increasing importance! The Vulnerable Atherosclerotic Plaque presents contributions from the best investigators in the field, skillfully edited for easy reading and lavishly illustrated with high-quality, full-color images. After a considered and concise introduction, the book concentrates on: Pathology of vulnerable plaque Triggers for plaque rupture Imaging of unstable plaque Management of vulnerable plaques Careful editing allows the authors to avoid repetition and provide comprehensive coverage of pathology, detection, and management. This thorough and authoritative reference will change the way interventionists look at the disease.

OCT is rapidly being adopted in cardiology practice. However, gap exists between the speed of technology development and the knowledge of cardiologists. Many cardiologists are not familiar with image interpretation and don’t have enough background/knowledge to use the information in clinical practice. This book will be designed for busy interventional cardiologists to become quickly familiar with this emerging technology so that they can take advantage of its power improve patient care and outcome.

Stroke is a major cause of death and the major cause of adult neurological disability in most of the world. Despite its importance on a population basis, research into the genetics of stroke has lagged behind that of many other disorders. However, the situation is now changing. Anincreasing number of single gene disorders causing stroke are being described, and there is growing evidence that polygenic factors are important in the risk of apparently "sporadic" stroke.Stroke Genetics provides an up-to-date review of the area, suitable for clinicians treating stroke patients, and both clinical and non-clinical researchers in the field of cerebrovascular disease. The full range of monogenic stroke disorders causing cerebrovascular disease, including ischaemicstroke, intracerebral haemorrhage, aneurysms and arteriovenous malformations, are covered. For each, clinical features, diagnosis, and genetics are described. Increasing evidence suggest that genetic factors are also important for the much more common multifactorial stroke; this evidence isreviewed along with the results of genetic studies in this area. Optimal and novel strategies for investigating multifactorial stroke, including the use of intermediate phenotypes such as intima-media thickness and MRI detected small vessel disease are reviewed. The book concludes by describing apractical approach to investigating patients with stroke for underlying genetic disorders. Also included is a list of useful websites.

Heart Physiology and Pathophysiology, 4E, provides the foundation for the scientific understanding of heart function and dysfunction, and bridges the gap between basic cardiovascular science and clinical cardiology. This comprehensive text covers all the important aspects of the heart and vascular system. The most important and relevant disorders are presented, with emphasis on the mechanisms involved. The first three editions of this book developed a reputation as the leading reference in cardiovascular science for researchers and academic cardiologists. This recent edition has been updated, expanded, and includes a number of new contributors. It has also been remodeled to expand its usage as a text reference for cardiology residents, practicing cardiologists, and graduate students. Key Features* The most comprehensive book available on this topic* Clear, concise, and complete coverage of all important aspects of cardiovascular physiology/pathophysiology* Completely updated version of the foremost reference on cardiovascular science, including new information on pathophysiology and electrophysiology* Useful tool in bridging the gap between basic science, pathophysiology, and clinical cardiology