Therapeutic Monoclonal Antibodies And Antibody Drug Conjugates Adc
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Therapeutic Monoclonal Antibodies and Antibody Products Their Optimization and Drug Design in Cancers
Author | : Veysel Kayser |
Publsiher | : Mdpi AG |
Total Pages | : 298 |
Release | : 2022-01-25 |
Genre | : Electronic Book |
ISBN | : 3036526870 |
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The book broadly deals with therapeutic monoclonal antibodies (mAbs) and various relevant topics, including different antibody formats such as Antibody-Drug Conjugates (ADC), bispecifics, nanoparticle-based mAbs and HER2+ cancers, immune checkpoint inhibitors and other closely related topics. Each paper was written by leading active research groups in their fields both from academia and industry. The book should be of interest to those scientists and researchers who develop or use biologics, biotherapeutics, biosimilars and biobetters in cancer treatment.
Antibody Drug Conjugates and Immunotoxins
Author | : Gail Lewis Phillips |
Publsiher | : Springer Science & Business Media |
Total Pages | : 378 |
Release | : 2012-12-13 |
Genre | : Medical |
ISBN | : 9781461454564 |
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This volume gathers the leading research on antibody-drug conjugates and immunotoxins. Following a rigorous overview, the volume delves into focused sections on all aspects of ADCs and ITs from clinical development through to targeted therapeutic applications and the latest technologies.
Antibody Drug Conjugates
Author | : Laurent Ducry |
Publsiher | : Humana Press |
Total Pages | : 317 |
Release | : 2013-08-03 |
Genre | : Medical |
ISBN | : 1627035427 |
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Antibody-drug conjugates (ADCs) represent a promising therapeutic approach for cancer patients by combining the antigen-targeting specificity of monoclonal antibodies (mAbs) with the cytotoxic potency of chemotherapeutic drugs. In Antibody-Drug Conjugates, expert researchers provide detailed protocols for many of the key ADC techniques necessary for working in the field. These chapters and methodologies are aimed at the key tasks necessary to identify a suitable target, properly design the mAb, the linker and the payload, as well as to conjugate them in a reproducible and scalable fashion. Written in the highly successful Methods in Molecular BiologyTM format, these detailed chapters include the kind of practical implementation advice that guarantees quality results. Authoritative and timely, Antibody-Drug Conjugates aims to further drive ADC development and thus help toward improving cancer treatments of the future.
Antibody Drug Conjugates
Author | : Laurent Ducry |
Publsiher | : Humana |
Total Pages | : 0 |
Release | : 2016-08-23 |
Genre | : Medical |
ISBN | : 1493960261 |
Download Antibody Drug Conjugates Book in PDF, Epub and Kindle
Antibody-drug conjugates (ADCs) represent a promising therapeutic approach for cancer patients by combining the antigen-targeting specificity of monoclonal antibodies (mAbs) with the cytotoxic potency of chemotherapeutic drugs. In Antibody-Drug Conjugates, expert researchers provide detailed protocols for many of the key ADC techniques necessary for working in the field. These chapters and methodologies are aimed at the key tasks necessary to identify a suitable target, properly design the mAb, the linker and the payload, as well as to conjugate them in a reproducible and scalable fashion. Written in the highly successful Methods in Molecular BiologyTM format, these detailed chapters include the kind of practical implementation advice that guarantees quality results. Authoritative and timely, Antibody-Drug Conjugates aims to further drive ADC development and thus help toward improving cancer treatments of the future.
Macromolecular Anticancer Therapeutics
Author | : L. Harivardhan Reddy,Patrick Couvreur |
Publsiher | : Springer Science & Business Media |
Total Pages | : 627 |
Release | : 2010-03-20 |
Genre | : Medical |
ISBN | : 9781441905079 |
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In spite of the development of various anticancer drugs, the therapy of cancer has remained challenging for decades. The current therapy of cancer is overwhelmed because of the inability to deliver therapeutics to all regions of a tumor in effective therapeutic concentrations, intrinsic or acquired resistance to the treatment with currently available agents via genetic and epigenetic mechanisms, and toxicity. As a result, cancer therapy using conventional therapeutics and different types of treatment regimens using this therapeutics has not led to a convincing survival benefit of the patients. In this context, Macromolecular therapeutics offer several advantages over conventional low molecular therapeutics by various ways such as, enable the use of larger doses of these agents by limiting the toxicity, by enhanced permeability and retention into tumors, by tumor targeting using tumor-specific antibodies, by specific inhibition of oncogenes using anticancer oligonucleotides etc. Cancer treatment using this macromolecular therapeutics has considerably improved the survival benefit for patients. As a result, various macromolecular therapeutics are already commercialized or are under clinical development. Although we are far from a real magic bullet today, looking at the pace of research and current success in this field of macromolecular therapeutics, it appears that we are approaching a magic bullet for the efficient treatment of cancer. Thus, we believe that the subject of this book is very timely, and that the book will fill an unmet need in the market. This book is unique and assembles various types and aspects of macromolecular anticancer therapeutics for cancer therapy in one shell and conveys the importance of this interdisciplinary field to the broad audience. Thus, in a nutshell, this book details the basics of cancer, and various therapeutic strategies such as those based on macromolecular therapeutics hence can become an important reference for practitioners, oncologists, medical pharmacologists, medicinal chemists, biomedical scientists, experimental pharmacologists, pharmaceutical technologists, and particularly it can essentially become a handbook of macromolecular therapeutics for cancer therapy for graduates, post-graduates and Ph.D. students in these fields.
Antibody Drug Conjugates
Author | : Kenneth J. Olivier, Jr.,Sara A. Hurvitz |
Publsiher | : John Wiley & Sons |
Total Pages | : 560 |
Release | : 2016-11-14 |
Genre | : Medical |
ISBN | : 9781119060802 |
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Providing practical and proven solutions for antibody-drug conjugate (ADC) drug discovery success in oncology, this book helps readers improve the drug safety and therapeutic efficacy of ADCs to kill targeted tumor cells. • Discusses the basics, drug delivery strategies, pharmacology and toxicology, and regulatory approval strategies • Covers the conduct and design of oncology clinical trials and the use of ADCs for tumor imaging • Includes case studies of ADCs in oncology drug development • Features contributions from highly-regarded experts on the frontlines of ADC research and development
Antibody Drug Conjugates and Immunotoxins
Author | : Gail Lewis Phillips |
Publsiher | : Springer |
Total Pages | : 378 |
Release | : 2012-12-12 |
Genre | : Medical |
ISBN | : 1461454573 |
Download Antibody Drug Conjugates and Immunotoxins Book in PDF, Epub and Kindle
This volume gathers the leading research on antibody-drug conjugates and immunotoxins. Following a rigorous overview, the volume delves into focused sections on all aspects of ADCs and ITs from clinical development through to targeted therapeutic applications and the latest technologies.
Monoclonal Antibody Directed Therapy
Author | : Veysel Kayser,Amita Datta-Mannan |
Publsiher | : Mdpi AG |
Total Pages | : 144 |
Release | : 2022-01-28 |
Genre | : Science |
ISBN | : 3036528733 |
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The book deals with therapeutic monoclonal antibodies (mAbs) broadly, and relevant topics such as challenges and opportunities, next-generation antibody products, Antibody-Drug-Conjugates (ADC), bispecifics, glycosylation, and T-cell engagers are covered. Each topic has been written by leading groups around the world and the book should be of interest to researchers from both academia and industry.