Therapeutics For Ebola Virus Disease 19 August 2022

Ebola virus disease (EVD) is a life-threatening disease caused by Ebola virus (EBOV; Zaire ebolavirus). Viruses of the genus Ebolavirus (of the family Filoviridae) can cause life-threatening disease. EBOV causes outbreaks of EVD, historically the most severe and most frequent. This guidance, due to the evidence available, is directed only to the treatment of EVD, the disease caused by EBOV (Zaire ebolavirus). During early EVD, patients present with a non-specific febrile illness, followed by gastrointestinal signs and symptoms that frequently lead to hypovolaemia, metabolic acidosis, hypoglycaemia, and multi-organ failure. EVD case fatality remains high, with a pooled case fatality rate of 60% (95% confidence interval [CI]: 47–73%) in outbreaks from 2010–2020. Following the publication of an RCT demonstrating superior efficacy of two EVD therapeutics, in comparison to the ZMapp control arm, WHO proposed to develop a new guideline. This is a new guideline written to accompany the optimized supportive care (oSoC) for EVD standard operating procedures. The guideline aims to summarize high quality evidence for EVD therapeutics and make recommendations for their use.

Trusted by clinicians for nearly 75 years, Conn’s Current Therapy presents today’s evidence-based information along with the personal experience and discernment of expert physicians. The 2022 edition is an excellent resource for a wide range of healthcare providers, including primary care, subspecialists, and allied health, providing current treatment information in a concise yet in-depth format. More than 300 topics have been carefully reviewed and updated to bring you state-of-the-art content in even the most rapidly changing areas of medicine. Offers personal approaches from recognized leaders in the field, covering common complaints, acute diseases, and chronic illnesses along with the most current evidence-based clinical management options. Follows a consistent, easy-to-use format throughout, with diagnosis, therapy, drug protocols, and treatment pearls presented in quick-reference boxes and tables for point-of-care answers to common clinical questions. Includes new and significantly revised chapters on COVID-19 and post-COVID syndrome, pyoderma gangrenosum, mitochondrial disease, gender affirming care, stem cell therapy, and artificial intelligence. Incorporates more electronic links throughout the text that connect the reader to apps and clinical prediction tools that can easily be accessed in practice. Features thoroughly reviewed and updated information from many new authors who offer a fresh perspective and their unique personal experience and judgment. Provides current drug information thoroughly reviewed by PharmDs. Features nearly 300 images, including algorithms, anatomical illustrations, and photographs, that provide useful information for diagnosis.

Trusted by clinicians for more than 75 years, Conn’s Current Therapy presents today’s evidence-based information along with the personal experience and discernment of expert physicians. The 2024 edition is a helpful resource for a wide range of healthcare providers, including primary care physicians, subspecialists, and allied health professionals, providing current treatment information in a concise yet in-depth format. Nearly 350 topics have been carefully reviewed and updated to bring you state-of-the-art content in even the most rapidly changing areas of medicine. Offers personal approaches from recognized leaders in the field, covering common complaints, acute diseases, and chronic illnesses along with the most current evidence-based clinical management options. Follows a consistent, easy-to-use format throughout, with diagnosis, therapy, drug protocols, and treatment pearls presented in quick-reference boxes and tables for point-of-care answers to common clinical questions. Incorporates electronic links throughout the text that connect the reader to apps and clinical prediction tools that can easily be accessed in practice. Features thoroughly reviewed and updated information from multiple expert authors and editors, who offer a fresh perspective and their unique personal experience and judgment. Provides current drug information thoroughly reviewed by PharmDs. Features nearly 300 images, including algorithms, anatomical illustrations, and photographs, that provide useful information for diagnosis.

The Ebola and Marburg viruses are a pair of filoviruses that are among the most lethal hemorrhagic viruses on the planet. The authors present a review of past and current research into these pathogens, including 12 papers addressing the structure of the viral proteins; genomic replication; molecular mechanisms of entry; pathogenesis in nonhuman primates, guinea pigs, and mice; virus modulation of innate immunity; and cellular and molecular mechanisms of Ebola pathogenicity and related approaches to vaccine development.

Ebola Virus Disease: From Origins to Outbreak covers Ebola virus disease in its entirety from its origins through major outbreaks in the past to the present day outbreak. It contains information on the West Saharan response to Ebola as well as highlights from the field in West Africa from Dr. Qureshi and Dr. Chughtai, helping to solve the primary question of what’s next and aiding in formulating a path forward. With a growing awareness of the devastating effects of this viral disease and an influx of topical research, this book provides the information the global community of researchers, clinicians and students need to better inform their research and study of Ebola virus disease. Includes perspectives from the 2014-2015 outbreak from the field Provides a detailed overview of the origins of Ebola virus through present day discoveries Written with an integrative approach, incorporating scientific research with insights from the field

The 4th World Congress on Genetics, Geriatrics and Neurodegenerative Diseases Research (GeNeDis 2020) focuses on the latest major challenges in scientific research, new drug targets, the development of novel biomarkers, new imaging techniques, novel protocols for early diagnosis of neurodegenerative diseases, and several other scientific advances, with the aim of better, safer, and healthier aging. The increase in the average length of life leads to the development of various diseases in the elderly population. This volume focuses on the sessions from the conference on Geriatrics.

The #1 annually updated general medical text—presents the most important diagnostic and treatment recommendations as well as the most useful new clinical developments in every field of adult medicine. For more than six decades, CURRENT Medical Diagnosis & Treatment has been delivering the authoritative information students, residents, and clinicians need to build their medical knowledge, expertise, and confidence. Written by top experts in their fields, this unmatched guide is formatted in a way that enables readers to find the answers they need quickly and easily. CURRENT Medical Diagnosis & Treatment 2024 reflects the latest developments in medicine, guidelines, references, and more. You’ll find authoritative, evidence-based coverage of more than 1,000 diseases and disorders along with a concise, yet thorough synopsis of diagnosis and treatment. This trusted classic covers all aspects of outpatient and inpatient care and includes discussion of new developments and breakthroughs in medicine. CURRENT Medical Diagnosis & Treatment 2024 features: A comprehensive approach to patient care, focusing on the diagnostic tools relevant to daily practice Coverage of more than 1,000 diseases and disorders Hundreds of drug treatment tables for quick access to indexed trade names Annual updates to topics in all chapters in a consistent format, drugs, tables, and images Year in Review highlighting the many topics with significant clinical changes over the last year Essentials of Diagnosis for most diseases/disorders Diagnostic and treatment algorithms present complex information in an at-a-glance style Hundreds of full-color photos and illustrations New to this edition: Latest USPSFT recommendations for cardiovascular risk prevention Significant new opioid prescribing guidelines from the CDC Clarification on the distinction between uncontrolled hypertensive and hypertension emergency Latest classification of lymphomas released by the WHO Recommendations for the initiation and titration of treatment for chronic hypertension in pregnancy Current treatment guidelines and medications for H pylori infection Classification of the role, dosing, and potential risks of JAK inhibitors and anti-23 antibody (Risankizumab) in the treatment of IBD Updates that underscore the growing utility of combination treatments for high LDL levels, especially among high and very high-risk patients The WHO revision of the pathological classification of renal cell carcinoma to assist with prognosis prediction and treatment decisions