Tracer Kinetics In Biomedical Research

1. Introduction. 2. Fundamentals of Tracer Kinetics. 3. The Noncompartmental Model of Multipool Systems. 4. The Compartmental Model. 5. Identifiability of the Tracer Model. 6. Using the Tracer Model to Estimate Kinetic Parameters. 7. Compartmental Versus Noncompartmental Kinetic Parameters. 8. Parameter Estimation: Some Fundamentals of Regression Analysis. 9. Parameter Estimation in Noncompartmental Models. 10. Parameter Estimation in Compartmental Models. 11. Precursor-Product Models. Appendices. Index.

In the past few years, the number of applications of tracers for in vivo biomedical studies has greatly increased. New analytical tools at the genetic and protein levels have spurred this growth, opening the door for a deeper understanding of metabolic events. This in turn promises to yield significant advances in the understanding and treatment of human disease. Now fully revised and expanded, Isotope Tracers in Metabolic Research, Second Edition is the established definitive text on stable and radioactive isotope tracers. In unique, multidisciplinary fashion, it presents comprehensive coverage of new methodological, mathematical, and theoretical approaches. This new Second Edition includes: All-new chapters on nuclear magnetic resonance, mass isotopomer analysis, and methods of protein metabolism analysis A completely updated categorized list of over 750 references Major advances in the development of mass isotopomer and positional isotopomer techniques, noninvasive isotope techniques for studying metabolic pathways, hyphenated techniques, and new tracer techniques The latest developments in quantification of DNA synthesis and mass spectrometry spurred by genome sequencing and proteomics New coverage of mathematical modeling Expanded coverage of microdialysis probes, laboratory procedures, and regulatory issues related to human studies In this complete guide to performing tracer studies, the authors systematically cover tracer selection, modeling considerations, sample derivitization, mass spectrometry analysis, and data interpretation. Problems and discussion questions highlight key points in each chapter. Isotope Tracers in Metabolic Research, Second Edition offers students and researchers a comprehensive, practical resource for utilizing the latest tracer methodologies.

Tracer Methods for In Vivo Kinetics: Theory and Applications summarizes and evaluates the variety of working formulas in applying tracer methods for kinetic studies in vivo. This book discusses the basic concepts, derives the important equations, and evaluates each working formula to ensure its proper application within the set of experimental conditions available. Organized into 12 chapters, this book starts with an overview of tracers such as radioactive atoms. This text then discusses the errors inherent in treating a two-pool system as though it were one pool. Other chapters describe how, from curves of tracer content of the labeled pool or of the secondary pool, a definitive evaluation is made of rate constants and rate of interflow and outflow in the two-pool open system. This book discusses as well the limited usefulness of a curve of specific gravity when information is limited to such a curve obtained from the secondary pool. This book is intended for mathematicians, biomedical scientists, and graduate students.

These lectures were prepared by the authors for Seminars to be held on June 6, 1983, in St.Louis, Missouri, under the spon­ sorship of the Radiopharmaceutical Science Council of the So­ ciety of Nuclear Medicine . All manuscript? were refereed . Tracer kinetics and the modeling of physiological and bio­ chemical processes in vivo are the focus of a contemporary di­ rection in biochemical research. Recent advances in instrumen­ tation (especially positron emission tomography and digital autoradiography) and parallel developments in the production of short-lived radionuclides and rapid synthetic chemistry to pre­ pare tracers that probe metabolism, flow, receptor-ligand kinetics, etc., are responsible for new scientific frontiers. These developments, coupled with biomathematics and computer science, make it possible to quantitatively evaluate tracer kinetic models in animals and man. (The choice of animal models in radiotracer design and tracer kinetics is the subject of a book edited by R.M.Lambrecht and W.C.Eckleman in press at Sprin­ ger Verlag.) Tracer kinetics and physiological modeling is truly multi­ disciplinary, as evidenced by the intellectual diversity and international representation observable in the list of contri­ butors . The lectures outline and attempt to show the transition from the theoretical description to the practical application of modeling for understanding normal and pathological processes .

This book constitutes the refeered proceedings of the 21st International Conference on Information Processing in Medical Imaging, IPMI 2009, held in Williamsburg, VA, USA, in July 2009 The 26 revised full papers and 33 revised poster papers presented were carefully reviewed and selected from 150 submissions. The papers are organized in topical sections on diffusion imaging, PET imaging, image registration, functional networks, space curves, tractography, microscopy, exploratory analyses, features and detection, image guided surgery, shape analysis, motion, and segmentation and validation.