Translational Research Methods For Diabetes Obesity And Cardiometabolic Drug Development
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Translational Research Methods for Diabetes Obesity and Cardiometabolic Drug Development
Author | : Andrew J. Krentz,Lutz Heinemann,Marcus Hompesch |
Publsiher | : Springer |
Total Pages | : 316 |
Release | : 2014-11-29 |
Genre | : Medical |
ISBN | : 9781447149200 |
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The world is beset by a pandemic of obesity and type 2 diabetes and the need for new drugs is startlingly clear; recent years have seen a huge increase in research activity to fill this gap. The development of new drugs for diabetes and obesity must be founded upon a sound appreciation of the pathophysiology of these common disorders. The dual defects of insulin resistance and impaired insulin secretion are fundamental to the pathogenesis and progression of obesity-associated type 2 diabetes. There is a need to explain how new drugs can counter insulin resistance and insulin deficiency to a broad range of professionals, from clinical scientists active in early (and later) phase drug development to specialist physicians and increasingly primary care doctors who must tailor drug regimens to the individual patient. Clinical research methods for measuring insulin action and insulin secretion have become well-established in proof-of-mechanism studies; however, selection of the best techniques is by no means straightforward. The purpose of the book is to aid the selection of the most appropriate techniques for assessing insulin action, insulin secretion and body composition in humans (with particular reference to new drugs) in phase 1 and 2 studies and aid the understanding of drug effects and non-drug treatment strategies on key biochemical-hormonal defects of obesity and type 2 diabetes. The book will assume a working knowledge of human physiology relating to glucose metabolism and will be of interest to biomedical scientists, pharmacologists, academics involved in metabolic research and clinicians practicing in these specialties.
Translational Research Methods in Diabetes Obesity and Nonalcoholic Fatty Liver Disease
Author | : Andrew J. Krentz,Christian Weyer,Marcus Hompesch |
Publsiher | : Springer |
Total Pages | : 556 |
Release | : 2019-04-02 |
Genre | : Medical |
ISBN | : 9783030117481 |
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This book aims to aid the selection of the most appropriate methods for use in early phase (1 and 2) clinical studies of new drugs for diabetes, obesity, non-alcoholic fatty liver disease (NAFLD) and related cardiometabolic disorders. Clinical research methods to assess the pharmacokinetics and pharmacodynamics of new diabetes drugs, e.g. the euglycemic clamp technique, have become well-established in proof-of-mechanism studies. However, selection of the most appropriate techniques is by no means straightforward. Moreover, the application of such methods must conform to the regulatory requirements for new drugs. This book discusses the need for new pharmacotherapies for diabetes, obesity and NAFLD and the molecular targets of drugs currently in development. Emerging technologies including functional imaging, circulating biomarkers and omics are considered together with practical and ethical issues pertaining to early phase clinical trials in subjects with cardiometabolic disorders. Translational Research Methods in Diabetes, Obesity, and Non-Alcoholic Fatty Liver Disease is of interest to biomedical scientists, pharmacologists, academics involved in metabolic research and clinicians practicing in these specialties.
Disease Control Priorities Third Edition Volume 5
Author | : Dorairaj Prabhakaran,Shuchi Anand,Thomas A. Gaziano,Jean-Claude Mbanya,Rachel Nugent |
Publsiher | : World Bank Publications |
Total Pages | : 466 |
Release | : 2017-11-17 |
Genre | : Medical |
ISBN | : 9781464805202 |
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Cardiovascular, respiratory, and related conditions cause more than 40 percent of all deaths globally, and their substantial burden is rising, particularly in low- and middle-income countries (LMICs). Their burden extends well beyond health effects to include significant economic and societal consequences. Most of these conditions are related, share risk factors, and have common control measures at the clinical, population, and policy levels. Lives can be extended and improved when these diseases are prevented, detected, and managed. This volume summarizes current knowledge and presents evidence-based interventions that are effective, cost-effective, and scalable in LMICs.
Pharmacotherapy of Obesity
Author | : John P. H. Wilding |
Publsiher | : Springer Science & Business Media |
Total Pages | : 127 |
Release | : 2008-01-08 |
Genre | : Medical |
ISBN | : 9783764374259 |
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After three introductory chapters that deal with the general theme of obesity – now regarded as a chronic disease – this volume discusses the drugs sibutramine and orlistat, which are approved for long-term use in the US and in much of the rest of the world. The three final chapters discuss future drug targets, like the central nervous system and gut hormones, and how to influence energy expenditure and substrate utilization.
High and Rising Mortality Rates Among Working Age Adults
Author | : National Academies of Sciences Engineering and Medicine,Division of Behavioral and Social Sciences and Education,Committee on National Statistics,Committee on Population,Committee on Rising Midlife Mortality Rates and Socioeconomic Disparities |
Publsiher | : Unknown |
Total Pages | : 135 |
Release | : 2021-12-02 |
Genre | : Electronic Book |
ISBN | : 0309684730 |
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The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment
Author | : Joerg Bluemel,Sven Korte,Emanuel Schenck,Gerhard Weinbauer |
Publsiher | : Academic Press |
Total Pages | : 716 |
Release | : 2015-03-13 |
Genre | : Medical |
ISBN | : 9780124171466 |
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The Nonhuman Primate in Drug Development and Safety Assessment is a valuable reference dedicated to compiling the latest research on nonhuman primate models in nonclinical safety assessment, regulatory toxicity testing and translational science. By covering important topics such as study planning and conduct, inter-species genetic drift, pathophysiology, animal welfare legislation, safety assessment of biologics and small molecules, immunotoxicology and much more, this book provides scientific and technical insights to help you safely and successfully use nonhuman primates in pharmaceutical toxicity testing. A comprehensive yet practical guide, this book is intended for new researchers or practicing toxicologists, toxicologic pathologists and pharmaceutical scientists working with nonhuman primates, as well as graduate students preparing for careers in this area. Covers important topics such as species selection, study design, experimental methodologies, animal welfare and the 3Rs (Replace, Refine and Reduce), social housing, regulatory guidelines, comparative physiology, reproductive biology, genetic polymorphisms and more Includes practical examples on techniques and methods to guide your daily practice Offers a companion website with high-quality color illustrations, reference values for safety assessment and additional practical information such as study design considerations, techniques and procedures and dosing and sampling volumes
Oxford Textbook of Global Public Health
Author | : Roger Detels,Martin Gulliford,Quarraisha Abdool Karim,Chorh Chuan Tan |
Publsiher | : Oxford University Press |
Total Pages | : 1717 |
Release | : 2017 |
Genre | : Medical |
ISBN | : 9780198810131 |
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Sixth edition of the hugely successful, internationally recognised textbook on global public health and epidemiology, with 3 volumes comprehensively covering the scope, methods, and practice of the discipline
Non Alcoholic Steatohepatitis NASH Metabolic Contributors and Therapeutic Targets
Author | : Magdalene K. Montgomery,Karine Clément,Shingo Kajimura |
Publsiher | : Frontiers Media SA |
Total Pages | : 320 |
Release | : 2022-09-07 |
Genre | : Medical |
ISBN | : 9782889769131 |
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