Tumor Microenvironment Tme And Tumor Immune Microenvironment Time New Perspectives For Prognosis And Therapy

Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.

This book offers outstanding approaches to understanding the role of the tumor microenvironment (TME) in cancer development and metastasis. The TME, with its multifaced role, is fundamental in the control and exacerbation of almost all cancer types. The outcome of many solid tumors is dependent on the modulation of the TME. Local tumor immunity, which is crucial in the control of cancer promotion, is one of the leading compounds of the TME. This book presents new insights and provides detailed and updated descriptions of the role of the TME in the control and the development of almost all cancer types. This book is an authentic source of knowledge, useful for researchers, medical doctors, students, and all individuals interested in understanding the mechanisms of cancer control and development.

Peritoneal Tumor Microenvironment of Cancers on Cancer Hallmarks: Perspectives of Translational Medicine provides readers with cutting-edge knowledge on tumor microenvironment. By exploring multiple aspects on tumor microenvironment, it gives an integrative insight on cancer diseases ranging from diagnosis to prediction of prognosis and individualized treatment.The book discusses topics such as clinical significance of tumor microenvironment, tumorigenesis and cancer progression, histopathological features of cancer in peritoneum, immune cells in tumor, exosomal cell-to-cell interactions, and therapeutic approaches to target tumor microenvironment. Additionally, it discusses tumor evolution during chemotherapy and metastasis, and future perspectives on identification and validation of biomarkers using liquid biopsy. This book is a valuable resource for cancer researchers, oncologists, medical doctors, and several members of biomedical field who want to understand the complex microenvironment of peritoneal tumors. Discusses how to apply tumor microenvironment knowledge to diagnosis, prediction of prognosis, and individualized treatment of cancer Provides readers with up-to-date knowledge on translational medicine, focusing on bench-to-bedside approach for cancer treatment and diagnosis Presents collaborative research works from the perspectives of medical doctors, cancer researchers, basic biological scientists, and bioinformaticians to provide integrative insights on tumor microenvironment

It is well known that the immune microenvironment is critical to the progression of genitourinary malignancies and benign diseases. A variety of cellular and molecular properties of the immune microenvironment may influence disease outcome by altering the balance of suppressive versus inflammatory or cytotoxic responses. Emerging evidence suggests that immunoediting is a key factor of phenotypic change, immunological alterations caused by physical activity or drug treatments could promote antitumor or anti-inflammatory activity. Conversely, microenvironment deficits or dysregulation can instigate or worsen pathological progression, thereby contributing to urinary disease development and progression. Thus, understanding how immune microenvironments react and maintain appropriate antitumor or anti-inflammatory responses is important for identifying actionable therapies to improve genitourinary health. Recent technological developments, particularly in the areas of genetic modification and redox indicators, provide hopeful new treatments not only in urinary cancer, kidney cancer, bladder cancer, relatively rare adrenocortical cancer, and penile cancer but also in begin diseases like kidney stones and kidney injuries. The purpose of this topic is to provide up-to-date reviews and original articles that highlight research on immunological mediators of tumor progression and inflammatory-related genitourinary diseases, which we hope will not only integrate our current understanding but crystallize nascent questions that will help move the field forward. This research topic aims to inspire novel insights into the immunity mechanisms, novel therapeutic targets, and effective combinational strategies of urinary immunotherapies.