Understanding Mitochondrial Dynamics And Metabolic Plasticity In Cancer Stem Cells Recent Advances In Cancer Treatment And Potential Therapeutic Approaches
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Understanding mitochondrial dynamics and metabolic plasticity in cancer stem cells Recent advances in cancer treatment and potential therapeutic approaches
Author | : Pramod Darvin,Varun Sasidharan Nair |
Publsiher | : Frontiers Media SA |
Total Pages | : 172 |
Release | : 2023-06-02 |
Genre | : Medical |
ISBN | : 9782832525043 |
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Metabolic Plasticity of Cancer
Author | : Tuuli Käämbre,Rafael Moreno-Sánchez,Sara Rodriguez-Enriquez |
Publsiher | : Frontiers Media SA |
Total Pages | : 176 |
Release | : 2020-12-24 |
Genre | : Medical |
ISBN | : 9782889662760 |
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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
The Heterogeneity of Cancer Metabolism
Author | : Anne Le |
Publsiher | : Springer |
Total Pages | : 186 |
Release | : 2018-06-26 |
Genre | : Medical |
ISBN | : 9783319777368 |
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Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.
Mitochondria and Cancer
Author | : Keshav Singh,Leslie Costello |
Publsiher | : Springer Science & Business Media |
Total Pages | : 294 |
Release | : 2009-04-05 |
Genre | : Medical |
ISBN | : 9780387848358 |
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Nearly a century of scientific research has revealed that mitochondrial dysfunction is one of the most common and consistent phenotypes of cancer cells. A number of notable differences in the mitochondria of normal and cancer cells have been described. These include differences in mitochondrial metabolic activity, molecular composition of mitochondria and mtDNA sequence, as well as in alteration of nuclear genes encoding mitochondrial proteins. This book, Mitochondria and Cancer, edited by Keshav K. Singh and Leslie C. Costello, presents thorough analyses of mitochondrial dysfunction as one of the hallmarks of cancer, discusses the clinical implications of mitochondrial defects in cancer, and as unique cellular targets for novel and selective anti-cancer therapy.
Mitochondrial Dysfunction
Author | : Lawrence H. Lash,Dean P. Jones |
Publsiher | : Elsevier |
Total Pages | : 527 |
Release | : 2013-10-22 |
Genre | : Science |
ISBN | : 9781483218618 |
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Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.
Characterizing the Multi faceted Dynamics of Tumor Cell Plasticity
Author | : Satyendra Chandra Tripathi,Mohit Kumar Jolly,Herbert Levine,Sendurai A. Mani |
Publsiher | : Frontiers Media SA |
Total Pages | : 336 |
Release | : 2021-03-01 |
Genre | : Science |
ISBN | : 9782889665235 |
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Metabolism in Cancer
Author | : Thorsten Cramer,Clemens A. Schmitt |
Publsiher | : Springer |
Total Pages | : 272 |
Release | : 2016-08-24 |
Genre | : Medical |
ISBN | : 9783319421186 |
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This textbook presents concise chapters written by internationally respected experts on various important aspects of cancer-associated metabolism, offering a comprehensive overview of the central features of this exciting research field. The discovery that tumor cells display characteristic alterations of metabolic pathways has significantly changed our understanding of cancer: while the first description of tumor-specific changes in cellular energetics was published more than 90 years ago, the causal significance of this observation for the pathogenesis of cancer was only discovered in the post-genome era. The first 10 years of the twenty-first century were characterized by rapid advances in our grasp of the functional role of cancer-specific metabolism as well as the underlying molecular pathways. Various unanticipated interrelations between metabolic alterations and cancer-driving pathways were identified and currently await translation into diagnostic and therapeutic applications. Yet the speed, quantity, and complexity of these new discoveries make it difficult for researchers to keep up to date with the latest developments, an issue this book helps to remedy.
Therapeutic Diagnosis Target Discovery Based on Metabolomics
Author | : Linsheng Liu,Bei Cao,Hiu Yee Kwan,Jiye Aa,Ying Zhou,Giuseppe Lucarelli |
Publsiher | : Frontiers Media SA |
Total Pages | : 126 |
Release | : 2022-04-27 |
Genre | : Science |
ISBN | : 9782889760114 |
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