Varicocele And Male Infertility

This unique textbook – the first of its kind – presents a thoughtful and comprehensive discussion of the significance of varicocele and its impact on male fertility. This hot topic is covered from a multitude of angles in seven thematic sections: origin and pathophysiology, clinical evaluation, medical and surgical therapy, controversies, pro and con debates, and clinical case scenarios. The scope of varicocele includes basic and transitional research, genetics, diagnostic testing with conventional and advanced molecular biology approaches, hormonal control, interventional therapy and assisted reproductive technology (ART). Repair of varicocele, which can be carried out by various methods, not only alleviates oxidative stress‐associated infertility but also prevents and protects against the progressive character of varicocele and its consequent upregulations of systemic oxidative stress. Even with the advances in the understanding of this intriguing disease and consensus on some areas such as diagnosis and pathophysiology, substantial controversy still exists, in particular concerning the benefits of treatment and to whom treatment should be offered. Additional chapters discuss, in depth, such controversies surrounding the role of varicocele in male infertility and present clinical case scenarios dealing with management of subclinical and clinical varicocele. A series of editorial comments is provided by the editors at the end of selected chapters, containing an objective and concise summary of the information from each chapter. In addition, chapters open up with key points for quick references and conclude with multiple choice questions and answers for immediate review and retention of the rich content. Generously illustrated, Varicocele and Male Infertility: A Complete Guide represents an invaluable tool for medical students in reproductive medicine as well as researchers and clinicians working in the field of infertility (e.g., urologists, gynecologists, reproductive endocrinologists, and embryologists) and is comprised of chapters written by leading and internationally recognized clinicians and scientists with expertise in varicocele, skillfully edited by leaders in the field.

This SpringerBrief analyzes varicocele from a novel approach, and provides the reader with a comprehensive view of its scientific and clinical significance. The Brief covers all the important aspects of varicocele related to infertility, from epidemiology to assisted reproduction techniques, contemplating pathophysiology, semen analysis, specialized sperm function tests, and clinical management including all available treatment options form three distinct perspectives, i.e., current concepts, consensus and controversies. Each topic is addressed using the same template, offering the best information from all angles to readers. This SpringerBrief is aimed at both clinicians and scientists involved in the study and care of male and female fertility, and is written by a team of three internationally recognized authors with expertise in andrology and male infertility. The text is the first of its kind, and presents an invaluable tool both for the basic scientists with an interest in reproductive medicine and for clinicians working in the field of infertility.

F. H. Comhaire Many diseases were, at the beginning, merely defined by the description of their clinical appearance. Next, the pathogenic mechanisms underlying the diseases were recognized. Since then, the proof of presence of the pathogenic agent or agents has been required to confirm the diagnosis. However, it sometimes happens that the pathogenic agent can be demonstrated without the disease being clinically evident. Confusion arising from this observation may cause endless, often purely emotional discussions between "believers" and "non-believers". Moreover, if the disease involves potential disturbance of male fertility, the problem is further obscured by the difficulty of defining man's fertility. Indeed, during the short history of andrology, the criteria for judging a man and his ejaculate as potentially fertile or infertile have repeatedly changed. Andrological "landmarks" in general do not hold up for long, and some scientists continue to set themselves the task of proving the "old" definitions invalid. Certainly, such developments are necessary to make science more exact and to improve medical care. However, while this research is being done, the male partners of barren marriages continue to seek advice and treatment. Common sense and an empirical approach in the handling of these cases may result in obviously encouraging results, which non-believers will ascribe to "witchcraft" and believers will see as confirmation of their opinions.

The new edition of this canonical text on male reproductive medicine will cement the book's market-leading position. Practitioners across many specialties - including urologists, gynecologists, reproductive endocrinologists, medical endocrinologists and many in internal medicine and family practice – will see men with suboptimal fertility and reproductive problems. The book provides an excellent source of timely, well-considered information for those training in this young and rapidly evolving field. While several recent books provide targeted 'cookbooks' for those in a male reproductive laboratory, or quick reference for practising generalists, the modern, comprehensive reference providing both a background for male reproductive medicine as well as clinical practice information based on that foundation has been lacking until now. The book has been extensively revised with a particular focus on modern molecular medicine. Appropriate therapeutic interventions are highlighted throughout.

Written by international authorities, this book is aimed at clinicians dealing with male patients rendered infertile by cancer therapy.

It is not surprising that so much investigation has been undertaken to establish the cause of childlessness, especially when the potentia coeundi of the male is not impaired. As long ago as 1957 the German Society for the Study of Fertility and Sterility was founded, embracing gynecology, andrology, and veterinary medicine. After its inception, meetings conducted in the spirit of its foundation were held every 2 years. This interdisciplinary, coordinated scientific work in the field of human reproduction achieved its value as a result of the stimuli provided by the permanent involvement of veterinary scientists. After about 20 years of activity, the Society adopted a highly differentiated pattern of work-directions in the field of human and veterinary medicine. Since 1976 annual meetings have been held on the topic of animal and human reproduction. These meetings have proved of great value, especially in the area of comparative medicine, and have led to excellent interdisciplinary associations. One of the most evident successes was the first extracorporal fertilization in humans with subsequent embryo transfer and full-term pregnancy. Gynecologists have found that in 40% of cases the cause of undesired childlessness rests with the male, and it is therefore no surprise that also in the field of andrology certain factors concerned with infertility have received great attention.

This book provides andrologists and other practitioners with reliable, up-to-date information on all aspects of male infertility and is designed to assist in the clinical management of patients. Clear guidance is offered on classification of infertility, sperm analysis interpretation and diagnosis. The full range of types and causes of male infertility are then discussed in depth. Particular attention is devoted to poorly understood conditions such as unexplained couple infertility and idiopathic male infertility, but the roles of diverse disorders, health and lifestyle factors and environmental pollution are also fully explored. Research considered stimulating for the reader is highlighted, reflecting the fascinating and controversial nature of the field. International treatment guidelines are presented and the role of diet and dietary supplements is discussed in view of their increasing importance. Clinicians will find that the book’s straightforward approach ensures that it can be easily and rapidly consulted.