Venous Thromboembolism In Advanced Disease

There is increasing recognition of the burden of venous thromboembolism (VTE) in patients with advanced incurable disease and the clinical, ethical, and philosophical challenges they may pose. With a growing elderly population and oncological therapies helping patients live longer with malignant disease, VTE is likely to be an ongoing problem. Whilst presentation, diagnosis, and treatment of VTE in general medicine is well established, its management within the palliative care setting is less clear-cut. Clinical presentation is often masked by other palliative symptoms, and symptoms can be consistent with those of other conditions; diagnosis is therefore underappreciated, and the condition can be difficult to manage. Bringing together contributions from international experts in the field of VTE and palliative care, this book explores the increasing challenges faced by healthcare professionals when managing VTE in advanced disease. Topics such as the epidemiology and pathogenesis of the condition are discussed. It appraises the current evidence informing the prevention, diagnosis, and treatment of VTE, with particular emphasis on its application to patients with incurable malignancy and non-malignant disease. Chapters are illustrated with key learning points and, where appropriate, case studies are presented to illustrate the decision-making processes that may occur when balancing the evidence with its impact on patient quality of life. This practical resource is invaluable for healthcare professionals working in all areas of medicine where patients with advanced cancer and non-malignant disease are cared for.

Showcasing the expertise of top-tier specialists who contributed to the newly released guidelines for the care of thrombosis in cancer patients, this exciting guide was written and edited by members of the American Society of Clinical Oncology panel, (ASCO), on the prevention and treatment of cancer-associated thrombosis, among others, and provides

Ever since the association between cancer and thrombosis was reported by Jean-Baptiste Bouillaud in the early 19th century, cancer-associated thrombosis has remained a challenging domain of cancer management. Thrombosis can at times be a lead to cancer diagnosis, while it often complicates medical situations as a coexisting disorder. In this handbook, the contributors have compiled comprehensive information on the subject to provide the reader a comprehensive review of current medical literature and guidelines for cancer-associated thrombosis. Key Features -clinically oriented text for application in healthcare settings -current, evidence-based literature reviews and references -includes guidelines on VTE prophylaxis, heparin effects and more -includes information about special cases Thrombosis in Cancer: A Medical Professional's Guide to Cancer Associated Thrombosis is an informative handbook for a broad range of readers in medicine, including generalists, residents, and graduate-level trainees.

This text provides comprehensive and timely coverage of the current knowledge of cancer-associated thrombosis, its pathogenesis, clinical features, prevention, and therapy. It specifically addresses the relationship between hemostatic systems and cancer, thus providing a unique and much needed focus. All of the contributors are acknowledged specialists in their fields and have experience conducting large clinical trials in oncology and thrombosis. Their discussions cover all aspects of the topic, from long-term complications to cancer surgery. It will be of interest to general practitioners, internists, oncologists, hematologists, and all physicians involved in the management of cancer patients.

The value of echocardiography in the diagnostic work-up of patients with suspected acute pulmonary embolism.- New developments in the thrombolytic therapy of venous thrombosis.- Mechanism of blood coagulation. Newer aspects of anticoagulant and antithrombotic therapy.MR-angiography in the diagnosis of pulmonary embolism.Scintigraphy-ventilation/perfusion scanning and imaging of the embolus.- Clinical course and prognosis of acute pulmonary embolism.- The molecular mechanisms of inherited thombophilia.

This book has been developed over numerous iterations within the Brigham and Women’s Hospital to provide the most critical information for trainees and physicians, and thus it represents a truly practical guidebook for anyone who needs the key information on the diagnosis, management and prevention of venous thromboembolism. Specific areas of focus include understanding the risk factors for VTE and the role of the right ventricle in PE pathophysiology. Efficient algorithms for diagnosis and exclusion of DVT and PE are emphasized. An state-of-the-art review of current techniques for the management of high risk VTE, including submassive and massive PE, is presented. The novel oral anticoagulants are revolutionizing the way VTE is treated and are covered in detail.​

With the aim of improving the prevention, diagnosis and treatment of venous thromboembolism (VTE) in day-to-day clinical practices, this reference provides a wide range of perspectives from international specialists on research concerning this disorder, exploring subjects have an impact in the field, including VTE and pregnancy, hypercoagulable sta

Venous Thromboembolic Disease, the second volume in the Contemporary Endovascular Management series, continues the current, succinct review of the rapidly evolving field of venous disease presented in Chronic Venous Insufficiency (volume 1). In recognition of the significant effects of venous disease on patients and the quickly changing modes of therapy in the field, this volume further fulfills the need for a comprehensive assessment of the treatment paradigms and innovative techniques now available. Volume 2 examines deep venous thrombosis, pulmonary embolism, thoracic outlet syndrome, and central venous disease from initial presentation through imaging and diagnosis to general and advanced therapies. As leaders in their field, the authors of Venous Thromboembolic Disease focus their contributions on current and relevant research and facts, specifically aiming to close knowledge gaps as well as to provide essential information for the practicing physician, the trainee, and the midlevel provider.