Vitiligo

Vitiligo has been, until recently, a rather neglected area in dermatology and medicine. Patients complain about this situation, which has offered avenues to quacks, and has led to the near orphan status of the disease. The apparently, simple and poorly symptomatic presentation of the disease has been a strong disadvantage to its study, as compared to other common chronic skin disorders such as psoriasis and atopic dermatitis. Vitiligo is still considered by doctors as a non disease, a simple aesthetic problem. A good skin-based angle of attack is also lacking because generalized vi- ligo is clearly epitomizing the view of skin diseases as simple targets of a systemic unknown dysregulation (diathesis), re? ecting the Hippocratic doctrine. This view has mostly restricted vitiligo to the manifestation of an auto-immune diathesis in the past 30 years. Thus, skin events, which are easily detected using skin biospies in most other situations, have not been precisely recorded, with the argument that a clinical diagnosis was suf? cient for the management (or most commonly absence of mana- ment) of the patient. This book is an international effort to summarize the information gathered about this disorder at the clinical, pathophysiological and therapeutic levels. Its primary aim is to bridge current knowledge at the clinical and investigative level, to point to the many unsolved issues, and to delineate future priorities for research.

Practical guidance based on expert experience and evidence for developing management strategies for vitiligo This complete guide to vitiligo provides a full appraisal of strategy for the treatment of this autoimmune disease that affects 1-2% of the world’s population. It addresses all aspects of vitiligo, covering the science, medical and surgical therapies, and the psychological evaluations and approaches based on the proper understanding of the causes and classification of a particular case. Management of vitiligo is challenging and requires a multipronged approach. Vitiligo: Medical and Surgical Management is a comprehensive, timely, state-of-the-art resource that will help those involved with affected patients better understand and treat this disease, which takes its toll on the mental wellness of those afflicted by it. It takes an evidenced-based approach to the disease’s treatment; provides an overview of the surgical management; covers tissue and cellular grafting; and more. Thoroughly guides those involved in the clinical aspects of vitiligo Aids diagnosis and classification of severity Balances evidence and experience Compiled by world-leading expert editors Comprehensive in nature, Vitiligo: Medical and Surgical Management contains a strong practical element, and is a welcome go-to source for practicing dermatologists and those training to become a dermatologist.

Vitiligo is a disorder having a significant impact in dark-skinned individuals. Along with the historical, cultural, and psychological aspects of the disease the multifactorial pathogenesis of this disorder is discussed in detail with special emphasis on the newer hypotheses proposed in the causation. Descriptions of the clinical aspects of the disease are supplemented with clinical photographs covering the latest therapeutic and surgical treatment options. Nonconventional treatments such as cosmetic camouflage and tattooing are also discussed. Topics of controversy such as the role of diet, patient selection for surgery, and so on, are covered in depth. Key Features Discusses the recent advances in treatment Evidence-based approach Quality of life and psychological aspects covered Nonconventional treatment options included with practical tips on vitiligo surgery Controversial topics covered

Vitiligo is often a frustrating condition for patients and dermatologists alike, but things are definitely looking up. Newer treatments are more effective and have fewer side effects. Furthermore, research in the pipeline now is very promising - both in eliminating the causes of vitiligo and forming new approaches to its treatment. As a dermatologist, I find that Vitiligo patients who stay abreast of the science behind the disease understand it better and make the best decisions regarding treatment, diet, and sun health. This books provides the medical information needed as well as practical tips for managing the condition. I do hope this book is useful for patients and families. Some of the material may appear at first to be "too hard" to read - but this is vitiligo - a lifelong condition with many causes and many approaches to treatment. If I had one wish beyond a cure for vitiligo it would be for it to become as well-known as freckles so that little children wouldn't feel the need to have printed cards explaining vitiligo to pass out to curious strangers. I hope this book answers all your questions about the disease. Covered in this book: - The skin - Diagnosis - Causes - Triggers - Associated conditions - Management - Remedies - Treatments - Vitiligo Community - Costs - Mental health ... and much more

This monograph is a comprehensive expose of the disorder vitiligo. The book introduces the topic with a presentation about its cultural effects in the Middle East where vitiligo is exceptionally disabling to the affected person. Nehru as Prime Minister of India stated that vitiligo was a major impediment to the successful development of India. The book includes sections on the definition of vitiligo based on a consensus of world experts on vitiligo. There is a complete description of its clinical manifestations including the extracutaneous sites by world experts. Differentiation of vitiligo from other forms of depigmentation associated with malignancies is included with sufficient photographs to document differences. A section will present the physiological changes associated with depigmentation - a little known phenomena. The complete histology, differential diagnosis and animal models are major sections. The animal models are important in formulating theories about the causes of vitiligo. Most clinicians will find this section very informative. The book finishes with a thorough treatise on the principles of therapy.

"Treatment of Skin Disease is your definitive source for managing the complete range of dermatologic conditions you're likely to encounter in practice. This medical reference book boasts an intuitive and easy to use format that covers the full spectrum of options, equipping you with not only standard treatment strategies, but second- and third-line therapies for instances when other alternatives fail"--Publisher's website

Leukoderma is a generic term for any pigmentary dilution, be it congenital or acquired, circumscribed or generalized, devoid of or partially lacking in pig mentation. In the approach to the diagnosis of leukoderma, we have generally first considered the age of onset, whether leukoderma was congenital or ac quired, the extent and pattern of involvement, and the degree of pigmentary dilution. The organization of this monograph reflects this approach. For ex ample, we have separated the section devoted to various disease entities into diffuse and circumscribed leukoderma and the latter into various etiologies such as genetic, metabolic, infectious, and endocrinologic. One of several justifications for this monograph is to present an approach to the diagnosis of leukoderma, as detailed in Part II. In formulating a guide for the physician, we have found some limitations to our previous approach; we therefore offer the following new classification based upon a clini cal-pathologic correlation. This could provide the means to describe both the clinical and pathologic findings in one term.

Although vitiligo has traditionally been very difficult to treat, anew breakthrough surgical treatment is expanding options forpractitioners and patients. Standard treatments depend on the severity of the condition andthe patient's feelings of disfigurement. Cover-up cosmetics workwell for some people. Other more sophisticated forms of treatmentinclude gradually developing color back in the depigmented areas(repigmentation) by PUVA or other ultraviolet light treatments, butthis is extremely slow and intensive, often requiring severalhundred treatments. This new form of treatment, which involves surgicallytransplanting melanocytes into the white areas, is most successfulin patients with stable vitiligo over less than 30% of their bodysurface area. It complements medical therapies in achievingcomplete and sustained repigmentation and is rapidly gainingpopularity in all major centers. This is the first book available which describes this majoradvance in detail. Explains the new treatment of surgically transplantingmelanocytes into the affected areas of the skin to providedermatologists and surgeons with the latest state-of-the-artinformation Written by the international leaders who pioneered thistreatment Presents all the latest information on the topic, eliminatingthe need to search through multiple sources for specific data