What Am I The Mechanism In Action

The first volume of Antibiotics was published in 1967 and contained a series of review papers on antibiotic actions. The editors, Drs. GOTTLIEB and SHAW, were aware of the rapid development of this field of study and provided a number of addenda in an effort to keep knowledge up to date while the book was in production. One year after the publication of Antibiotics I, this editor had a conference with Dr. KONRAD F. SPRINGER in which it became clear that another volume on actions of antibiotics would be necessary. For a variety of reasons, this was delayed until 1975 and became Antibiotics III. It did not contain addenda since it was recognized by the editors, Drs. CORCORAN and HAHN, that still another volume would have to follow and that in a moving field, such as the study of the actions of antibacterial drugs, no publication can be definitive or remain current, except for a limited period of time. The editors of Volume III grouped the contributions into sections: 1. Inter ference with nucleic acid biosyntheses, 2. Interference with protein biosynthesis, and 3. Interference with cell wall/membrane biosynthesis, specific enzyme sys tems, and those in which the mode of action was not known with certainty.

This book is open access under a CC BY license. This book is the first to develop explicit methods for evaluating evidence of mechanisms in the field of medicine. It explains why it can be important to make this evidence explicit, and describes how to take such evidence into account in the evidence appraisal process. In addition, it develops procedures for seeking evidence of mechanisms, for evaluating evidence of mechanisms, and for combining this evaluation with evidence of association in order to yield an overall assessment of effectiveness. Evidence-based medicine seeks to achieve improved health outcomes by making evidence explicit and by developing explicit methods for evaluating it. To date, evidence-based medicine has largely focused on evidence of association produced by clinical studies. As such, it has tended to overlook evidence of pathophysiological mechanisms and evidence of the mechanisms of action of interventions. The book offers a useful guide for all those whose work involves evaluating evidence in the health sciences, including those who need to determine the effectiveness of health interventions and those who need to ascertain the effects of environmental exposures.

["Version: Dec 2022"] ► OVERVIEW: ♦ An "information-including medicine" is a material that the rendition of its respective physical information via a certain part of the living system termed "parallel body" leads to its corresponding biotic qualities in the living being. Viremedy, homeopathic medicines, and the so-called intentional healing medicines are among such medicines. ♦ Viremedy, as a basic remedy, could raise the vitality of the living creature within the framework of its nature. A rise in vitality means "a general increase in the fulfillment degree of biotic capabilities, such as resistance (resilience) to exogenous and endogenous stresses, in the broad sense". This basic remedy improves the natural regulatory and healing operations. ♦ In this text, allowing for the related facts and experiments, "the Physical Essence" and "the Mechanisms of the Actions" of information-including medicines have been generally explicated by putting forward a working theory. Additionally, "Viremedy", "its Origin", and some relevant topics have been presented. These topics are also included: "Some Controlled Experiments Conducted About any Effects of Viremedy on Vitality"; "Some Points About the Holistic Healing Process Actuated by Viremedy Use"; "Some Application Methods of Viremedy"; "The Possible Use of Other Treatments Together With Viremedy". (What is entitled the "Improved Homeopathy" has been briefly introduced in this synopsis as well.) ♦♦ As a rule, facts, rather than words, are the final judge. /●●●/ ► Information-including medicines are broadly used in practice in some therapeutic modalities like homeopathy, etc. ♦ There are controversial discussions about such medicines and the related topics. For instance, in view of the high dilution of homeopathic medicines, sometimes beyond Avogadro’s Limit, some scholars have considered them the inert substances called Placebo, having no specific virtue! Oppositely, some others have counted homeopathy as a credible therapeutic modality. ♦ Here, regarding an interdisciplinary approach, "the Physical Essence" and "the Mechanisms of the Actions" of information-including medicines have been generally clarified by putting forward a comprehensive theory. In light of this theory, the related facts can be explained and the results of some related experiences can be methodically predicted. Allowing for this theory, we can also find suitable ways for "the reproduction and the reinforcement of the special information-including remedy named Viremedy", "keeping this remedy in appropriate conditions", "the various methods of Viremedy application", and "the apposite application of other treatments, like homeopathic treatments, together with this remedy". ♦ Viremedy is Not a Monopolistic Production or Finding of any Person or Group. ♦♦ Most of all, facts, like the results of the appropriate controlled experiences suitably designed and performed to correctly evaluate the degree of vitality, are the final judge. /●●●/ ► SOME RELATED DOMAINS: Health and Medical Sciences, Integrative Medicine, Holistic Medicine, Complementary and Alternative Medicine, Parallel Body Medicine, Information Medicine, So-called Energy Medicine, Homeopathy, Improved Homeopathy, Healing, Natural Medicine (Naturopathic Med.), Vitherapy, Holism, Information-including Medicines, Modern Physics, Evidence-based Medicine /●●●/ NOTIFICATION: ►► This book in paperback and Kindle formats can be bought from "AMAZON". ♦♦ All sales revenue of the book, the author’s share, will be spent on the activities involving Viremedy and the related matters like accomplishing the studies, improving Viremedy use, etc. - Citation: Esmaeili, Kamyar: «Information-including Medicines; Physics and Mechanism of Action (With Emphasis on "Viremedy") A Synopsis [Subtitle: Viremedy, Homeopathic Medicines, and the So-called Intentional Healing Medicines]». Independently Published [Kindle Direct Publishing Platform]; Pp. 251; Version: Dec 2022. ♦ The Book, especially in PDF format, has also been presented on some websites like https://sites.google.com/site/viremedy, archive.org, etc. ►► Viremedy is Not a Monopolistic Production or Finding of any Person or Group. ►►► https://sites.google.com/site/viremedy

The idea for publishing these books on the mechanism of action and on the biosynthesis of antibiotics was born of frustration in our attempts to keep abreast of the literature. Gone were the years when we were able to keep a biblio graphy on antibiotics and feel confident that we could find everything that was being published on this subject. These fields of investigation were moving for ward so rapidly and were encompassing so wide a range of specialized areas in microbiology and chemistry that it was almost impossible to keep abreast of developments. In our naivete and enthusiasm, however, we were unaware that we were toying with an idea that might enmesh us, that we were creating an entity with a life of its own, that we were letting loose a Golom who instead of being our servant would be our master. That we set up ideals for these books is obvious; they would be current guides to developments and information in the areas of mechanism of action and bio synthesis of antibiotics. For almost every subject, we wished to enlist the aid of an investigator who himself had played a part in determining the nature of the phenomena that were being discussed. One concept for the books was that they include only antibiotics for which a definitive, well-documented mechanism of action or biosynthetic pathway was known.

When Antibiotics I was published in 1967, the teleological view was held by some that" antibiotics" were substances elaborated by certain microorgan isms for the purpose of competing with other microorganisms for survival in mixed ecological environments. However, not only had J. EHRLICH and his associates shown 15 years earlier that chloramphenicol was produced by Strepto myces venezuelae in cultures of sterilized soils but not in parallel cultures of the same soils which were not sterilized, but operationally, the search for anti cancer antibiotics was actively under way (Antibiotics I reporting on numerous such substances), although the concept of antibiosis could not logically justify such undertakings. This editor hesitates to accept the use of the term "antibiotic" for anti microbial agents of non microbiological origins which is sometimes encountered, but neither does he subscribe to the view that antibiotics are in some fundamental manner different from chemotherapeutic substances of other origins. Modes and mechanisms of action of chemotherapeutic compounds are not systematic functions of their origins nor of the taxonomical position of the target organisms. Consequently, in the selection of topics for Antibiotics III (published in 1975), synthetic drugs and natural products of higher plants (alkaloids) were represented, along with antibiotics in the strict sense of the definition. We now present Antibiotics V, for whose assembly the same selection criteria were applied as for Antibiotics Ill. The aggregate length of the contributions rendered it impractical to place the entire text between the covers of one book.

This volume is the third in the series devoted to Antibiotics initiated by Springer Verlag in 1967. The first two volumes were devoted to the Mode of Action of Antibiotics and Biogenesis, respectively and were received graciously. During the intervening years these two works have been used often by research workers and students alike and have been quoted extensively. Although a number of other excellent treatises on antibiotics have appeared, the Springer series has set a standard for thoroughness and quality that meets the need of the scientific community. It is against this background that the present Editors set about the preparation of a third volume in the Series on Antibiotics. Since the appearance of Volume I, also dealing with Mechanism of Action, tremendous strides have been made in the depth and breadth of our knowledge of molecular biology, microbial chemistry and molecular pharmacology and of their direct application to studies on the mode of action of drugs. The field of molecular biology itself was in its relative infancy during the preceding decade and the unique role played by many anti biotics in the development of our understanding of nucleic acid synthesis and function and its relationship to protein synthesis and cell physiology has led rapidly to a very precise, understanding of how many of these same antibiotics inhibit susceptible cells.