Xpert Mtb Rif Implementation Manual

In December 2010, WHO first recommended the use of the Xpert MTB/RIF assay. The WHO's policy statement was supported by a rapid implementation document, which provided the technical "how-to" and operational considerations for rolling out the use of the assay. An unprecedented uptake of this new technology followed the release of WHO's policy: by the end of March 2014, more than 2,300 GeneXpert instruments and more than 6 million Xpert MTB/RIF cartridges had been procured in the public sector in 104 countries eligible for concessional prices. An Expert Group was convened by WHO in May 2013 to review the current body of evidence on use of Xpert MTB/RIF. The resulting recommendations from the Expert Group are included in the WHO Policy update, which widens the recommended use of Xpert MTB/RIF, including for the diagnosis of paediatric TB and on selected specimens for the diagnosis of extrapulmonary TB, and includes an additional recommendation on the use of Xpert MTB/RIF as the initial diagnostic test in all individuals presumed to have pulmonary TB. The accompanying Xpert MTB/RIF implementation manual has been developed to replace the first edition and takes into consideration the current body of evidence and operational experiences available, in the context of the Policy update.

Tuberculosis is an infection of the lungs caused by Mycobacterium tuberculosis and related species. It is prevalent in tropical regions and continues to occur in more than 10 million new individuals annually and despite many advances in medicine, still results in 1.3 million deaths annually. This clinical practice handbook presents information on all topics related to the disease, including its epidemiology, microbiology, clinical features, diagnostic procedures, treatments, BCG vaccination and infection control in health facilities. Special topics such as the treatment of tuberculosis is pediatric patients, surgery, multi-drug resistance and adverse reactions to tuberculosis drugs are also covered. Information is presented in 16 simple easy-to read chapters with key figures, tables and references that help to explain relevant topics. Tuberculosis: A Clinical Practice Guide is an ideal reference manual for medical students and healthcare personnel seeking information about tuberculosis.

For nearly 40 years, Oh’s Intensive Care Manual has been the quick reference of choice for ICU physicians at all levels of experience. The revised 8th edition maintains this tradition of excellence, providing fast access to practical information needed every day in today’s intensive care unit. This bestselling manual covers all aspects of intensive care in sufficient detail for daily practice while keeping you up to date with the latest innovations in the field. Short, to-the-point chapters distill the essential information you need to know for safe, effective care of patients in the ICU. Each topic includes theoretical knowledge, practical methods of treating the condition described, a review of the available evidence, and common pitfalls in treatment and management. Ideal for daily quick reference as well as an efficient review for professional examinations in critical care medicine.

Chapter 1. Introduction -- chapter 2. Disease burden and 2015 targets assessment -- chapter 3. TB case notifications and treatment outcomes -- chapter 4. Drug-resistant TB -- chapter 5. Diagnostics and laboratory strengthening -- chapter 6. Addressing the co-epidemics of TB and HIV -- chapter 7. Financing -- chapter 8. Research and development -- Annexes.

Tuberculous Meningitis: Manual of Diagnosis and Therapy focuses on the most common and most lethal manifestation of tuberculosis of the central nervous system. It includes up-to-date reviews of the diagnosis, treatment, and management of tuberculous meningitis in adults and children. Extensive guidance is provided for the treatment of drug-sensitive and drug-resistant tuberculosis and tuberculous meningitis. Clinicians and researchers will find the beginning chapters on immunopathology and epidemiology of great use in their efforts to develop new strategies for the diagnosis and treatment of tuberculous meningitis. Written by international contributors from countries most affected by tuberculosis Describes clinical and neuroimaging features of tuberculous meningitis Examines laboratory methods for detecting Mycobacterium tuberculosis Reviews international and national guidelines for the treatment of tuberculosis and tuberculous meningitis

The Oxford Handbook of Humanitarian Medicine is a practical guide covering all aspects of the provision of care in humanitarian situations and complex emergencies. It includes evidence-based clinical guidance, aimed specifically at resource limited situations, as well as essential non-clinical information relevant for people working in field operations and development. The handbook provides clear recommendations, from the experts, on the unique challenges faced by health providers in humanitarian settings including clinical presentations for which conventional medical training offers little preparation. It provides guidance for syndromic management approaches, and includes practical guidance on the integration of context specific mental health care. The handbook goes beyond the clinical domain, however, and also provides detailed information on the contextual issues involved in humanitarian operations, including health systems design, priorities in displacement, security and logistics. It outlines the underlying drivers at play in humanitarian settings, including economics, gender based inequities, and violence, guiding the reader through the epidemiological approaches in varied scenarios. It details the relevance of international law, and its practical application in complex emergencies, and covers the changing picture of humanitarian operations, with increasingly complicated and chaotic contexts and the escalation of violence against humanitarian providers and facility. The Oxford Handbook of Humanitarian Medicine draws on the accumulated experience of humanitarian practitioners from a variety of disciplines and contexts to provide an easily accessible source of information to guide the reader through the complicated scenarios found in humanitarian settings.

This issue of Clinics in Chest Medicine, edited by Dr. Charles L. Daley and Dr. David Lewinsohn, focuses on Tuberculosis. Topics include: Epidemiology of Tuberculosis (TB) in the United States; Immunology of Tuberculosis; Tuberculosis and Biologics; Laboratory Diagnosis of Tuberculosis; Supranational Tuberculosis Reference Laboratories (a global approach); Treatment of Drug Susceptible Tuberculosis; Treatment of Drug-Resistant Tuberculosis; New Drugs for the Treatment of Tuberculosis; Diagnosis of Latent Tuberculosis: the Role of Interferon Gamma Release; Treatment of Latent Tuberculosis; Management of Children with Tuberculosis; Tuberculosis and HIV; The Future of Vaccines for Tuberculosis; and Preventing Transmission of M. Tuberculosis.