A Point On Glass

The manner; in which Sir Isaac Newton has published his philosophical discoveries; occasions them to lie very much concealed from all; who have not made the mathematics particularly their study. He once; indeed; intended to deliver; in a more familiar way; that part of his inventions; which relates to the system of the world; but upon farther consideration he altered his design. -Introduction

Carried out over a period of ten years, this is a listing of scientific instruments dating before 1920, preserved in many collections throughout the island of Ireland. It gives location, date, and description for each of the more than 5,000 entries, together, where appropriate, with relevant accompanying detail. It demonstrates clearly that Ireland has an important resource which hitherto had not been appreciated. It also preserves information about collections which have since been lost, sold, or otherwise dispersed.

The basic principles are explained with examples from student's daily life situations and every topic is followed by thought-provoking questions. Relevant illustrations have been given, wherever necessary. The language used is simple and lucid which keeps the interest of the students alive till the end of the topic.

Frequently attempts to design experiments utilizing the methodology de scribed in articles in trade journals can be frustrating. Description of procedures, because of space constraints, are not always complete. The present volume attempts to bring together in one reference source many of the techniques which are utilized in the study of the kidney. It provides a thorough compendium of research tools, framed by the critical analysis of the theoretical background of renal physiology, biochemistry, and pharmacology discussed in Volume 4A. Some areas previously dealt with are not covered from a methodological point of view since adequate information does exist elsewhere (e.g., methods of whole kidney ATPase isolation). Since drugs acting on the kidney may alter not only functional but anatomical integrity, a chapter on the preparation of tissue for morphological studies has been included. The important developments in analy sis of minute (ultramicro) quantities of tissue and biological fluids, as well as methodological advances in studies of the isolated kidney, are thoroughly covered. It is my hope that investigators, research fellows, and graduate students will benefit from the information contained in this volume and that, together with its companion tome, it will be a ready reference for the renal physiologist, the renal pharmacologist, and the nephrologist. The contributors have provided painstaking descriptions and, when re quired, mathematical analyses of the techniques described herein. I wish to thank all of them for their enthusiasm and the excellence of their contributions.