Bone Repair Biomaterials

Bone Repair Biomaterials: Regeneration and Clinical Applications, Second Edition, provides comprehensive reviews on materials science, engineering principles and recent advances. Sections review the fundamentals of bone repair and regeneration, discuss the science and properties of biomaterials used for bone repair, including metals, ceramics, polymers and composites, and discuss clinical applications and considerations, with chapters on such topics as orthopedic surgery, tissue engineering, implant retrieval, and ethics of bone repair biomaterials. This second edition includes more chapters on relevant biomaterials and a greatly expanded section on clinical applications, including bone repair applications in dental surgery, spinal surgery, and maxilo-facial and skull surgery. In addition, the book features coverage of long-term performance and failure of orthopedic devices. It will be an invaluable resource for researchers, scientists and clinicians concerned with the repair and restoration of bone. Provides a comprehensive review of the materials science, engineering principles and recent advances in this important area Presents new chapters on Surface coating of titanium, using bone repair materials in dental, spinal and maxilo-facial and skull surgery, and advanced manufacturing/3D printing Reviews the fundamentals of bone repair and regeneration, addressing social, economic and clinical challenges Examines the properties of biomaterials used for bone repair, with specific chapters assessing metals, ceramics, polymers and composites

Bone substitute biomaterials are fundamental to the biomedical sector, and have recently benefitted from extensive research and technological advances aimed at minimizing failure rates and reducing the need for further surgery. This book reviews these developments, with a particular focus on the desirable properties for bone substitute materials and their potential to encourage bone repair and regeneration. Part I covers the principles of bone substitute biomaterials for medical applications. One chapter reviews the quantification of bone mechanics at the whole-bone, micro-scale, and non-scale levels, while others discuss biomineralization, osteoductivization, materials to fill bone defects, and bioresorbable materials. Part II focuses on biomaterials as scaffolds and implants, including multi-functional scaffolds, bioceramics, and titanium-based foams. Finally, Part III reviews further materials with the potential to encourage bone repair and regeneration, including cartilage grafts, chitosan, inorganic polymer composites, and marine organisms. Provides a detailed and accurate overview of the bone substitute biomaterials, a fundamental part of the biomaterials and biomedical sector Provides readers with the principles of bone substitute biomaterials Reviews biomaterials for bone regeneration

Translating Biomaterials for Bone Graft: Bench-top to Clinical Applications brings together the current translational research in bone tissue engineering, from design to application – from materials, drugs and biologic delivery used for bone graft applications to pre-clinical and clinical considerations. The book also discusses the regulatory approval pathways, which involves consideration of the class of devices; whether they are similar to existing solutions, minimal manipulation of donor tissue or completely novel materials, drugs and biologics. These considerations drive the ability to successfully transition the latest generations of bone graft materials into the clinics. Chapters come from materials scientists, clinicians, researchers, and consultants and provide a holistic understanding of the field. As such, the book is a state-of-the-art reference to bone therapies and should appeal to clinicians, scientists, as well as students interested in the current research and/or practices in the field of bone regeneration and restoration.

Focusing on bone biology, Bone Tissue Engineering integrates basic sciences with tissue engineering. It includes contributions from world-renowned researchers and clinicians who discuss key topics such as different models and approaches to bone tissue engineering, as well as exciting clinical applications for patients. Divided into four sections, t

Bioactive Materials for Bone Regeneration summarizes research advances on the topic, including sections on the characteristics of biomaterial-induced microenvironments, interactions of bioactive materials with stem cells and tissues, and the immunomodulatory microenvironment induced by biomaterials and its effects on osteogenesis. As the regeneration of large-size bone tissue defects represents a significant clinical challenge, this book demonstrates how new biomaterials with specific chemical and physical characteristics may interact with the host and create a unique micro-environment that actively facilitates stem cell differentiation along a specific lineage, thus stimulating tissue regeneration.

Biomaterials Effect on the Bone Microenvironment Practical resource on clinical bone regeneration from a variety of related interdisciplinary researchers Biomaterials Effect on the Bone Microenvironment focuses on the structure-activity relationship between bone biomaterials and microenvironment regulation, presenting a systematic exposition from all aspects of biomaterials regulated microenvironment in bone regeneration and covering design strategies, applications, and mechanisms of biomaterials that regulate bone microenvironment, along with the methods for manufacturing biomaterials and their clinical translation. The subject’s potential challenges and future development direction are discussed, and the design and initiative principle of tailored biomaterials with various features, including bioactive components and physicochemical property, are elucidated in depth. Numerous biomaterials, including natural and synthetic, are summarized and compared. Their advantages and features are also evaluated, particularly in bone microenvironmental regulation and bone generation. Moreover, the stimulation mechanism of the microenvironment to bone generation is discussed in detail, including mechanical-support effect, redox effect, pro-angiogenesis effect, inflammatory immune effect, and anti-aging effect. Biomaterials Effect on the Bone Microenvironment provides further coverage of sample topics such as: Role of bone microenvironment and its associated biomaterials in modulation bone diseases, reviewing the biomaterials used to regulate bone microenvironment Relationship between biological factors of various materials and physiological functions in bone microenvironment Application of the third generation of biomaterials, which would regenerate the bone to regulate bone microenvironment Emerging biological material manufacturing technology and mechanisms of novel biomaterial modulating microenvironment for bone regeneration Future outlook of bone tissue engineering along with the general process of bone remodeling and regeneration With comprehensive coverage of one of the most promising and valuable candidates for clinical bone regeneration, Biomaterials Effect on the Bone Microenvironment is an ideal resource for materials scientists, biotechnologists, biochemists, bioengineers, orthopedists, and clinical chemists who want to stay on the cutting edge of this rapidly evolving field.

Peptides and Proteins as Biomaterials for Tissue Regeneration and Repair highlights the various important considerations that go into biomaterial development, both in terms of fundamentals and applications. After covering a general introduction to protein and cell interactions with biomaterials, the book discusses proteins in biomaterials that mimic the extracellular matrix (ECM). The properties, fabrication and application of peptide biomaterials and protein-based biomaterials are discussed in addition to in vivo and in vitro studies. This book is a valuable resource for researchers, scientists and advanced students interested in biomaterials science, chemistry, molecular biology and nanotechnology. Presents an all-inclusive and authoritative coverage of the important role which protein and peptides play as biomaterials for tissue regeneration Explores protein and peptides from the fundamentals, to processing and applications Written by an international group of leading biomaterials researchers