A Primer For Radioimmunotherapy And Radionuclide Therapy

Nuclear Medicine Therapy presents the state of the art in targeted radionuclide therapy, both in clinical practice and contemporary clinical investigation and trials. With contributions from an internationally-distinguished group of physicians and scientists, the book is devoted entirely to the use of nuclear medicine techniques and technology for therapy of malignant and benign diseases. Individual chapters cover the scientific principles and clinical applications of radionuclide therapy and the state of clinical trials of agents currently under investigation in the therapy of tumors involving virtually every organ system. Due to overlapping interest in techniques, indications, and clinical use, the development of radionuclide therapy attracts considerable input from other medical specialists whose collaboration is essential, including radiation and medical oncologists, hematologists, diagnostic radiologists, hepatologists, endocrinologists, and rheumatologists. And because radionuclide therapy is a rapidly evolving field of nuclear medicine, it is the aim of this volume to appeal to all specialists involved in targeted radionuclide therapy and to contribute to the standardization of the practice globally.

Reflecting the past 20 years of intense research in radioimmunotherapy, this timely reference surveys an expansive breadth of topics on the evolving developments in radiation therapy. Placed in the context of advances in cancer treatment, chapters progress systematically from basic principles and properties of radionuclides to detailed summaries of

Radioimmunotherapy, also known as systemic targeted radiation therapy, uses antibodies, antibody fragments, or compounds as carriers to guide radiation to the targets. It is a topic rapidly increasing in importance and success in treatment of cancer patients. This book represents a comprehensive amalgamation of the radiation physics, chemistry, radiobiology, tumor models, and clinical data for targeted radionuclide therapy. It outlines the current challenges and provides a glimpse at future directions. With significant advances in cell biology and molecular engineering, many targeting constructs are now available that will safely deliver these highly cytotoxic radionuclides in a targeted fashion. A companion website includes the full text and an image bank.

This book covers scientific, clinical, and educational aspects of radiotheranostics in cancer control. Setting the framework, the first volume defines radiotheranostics and describes the history of radionuclide therapy and theranostics, and the biology of cancer. It examines the clinical applications of unconjugated radionuclides, such as 131I and 223Ra, and of radionuclide-conjugated cancer-specific vectors: peptides, small molecules, antibodies, and nanoparticles; introduces clinical trials and drug development; and reviews epidemiological studies and the adverse effects of radionuclide therapy – both radiation injuries and chemical toxicity. It presents the chemistry and physics of radionuclide production, discusses radioactivity measurements and traceability, and addresses important instrumentation aspects: calibration, quantitative imaging, and quality control. Volume I concludes with guidance on the education, training, and competence of a radiotheranostic multidisciplinary team and summarizes the principal physics characteristics of theranostics today – including many to be expanded in the second volume – while offering a glimpse into tomorrow. This volume provides the foundations for the more advanced second volume, which explores dosimetric and radiation safety, aiming to empower medical physicists and demonstrate to the cancer community how to improve cancer control and yield increased patient survival times.It will be a valuable reference for medical and health physicists with basic knowledge of nuclear medicine. Key Features Provides a comprehensive introduction to the topic, presenting readers with thorough treatment in a cohesive two-volume book Presents a rigorous approach while remaining accessible to students and trainees in the field Contains consistent and extensive references to allow readers to delve deeper into the subject

Reflecting the past 20 years of intense research in radioimmunotherapy, this timely reference surveys an expansive breadth of topics on the evolving developments in radiation therapy. Placed in the context of advances in cancer treatment, chapters progress systematically from basic principles and properties of radionuclides to detailed summaries of current cancer therapies. Up to date, clearly organized, and thorough-sure to become a standard in the field! Providing comprehensive treatment on radiolabeled antibody therapy, Radioimmunotherapy of Cancer reviews dosimetric principles and clinical dosimetry of radioimmunotherapy in the targeting and delivery of radiation describes tumor architectures and outlines novel constructs for radionuclide delivery analyzes a variety of improved targeting approaches, including pretargeting contextual analysis of extracorporeal techniques in radioimmunotherapy details studies from the radiotherapy of lymphoma, solid tumors, and ovarian cancer and the targeted radiotherapy of neuroblastoma and squamous head and neck cancer and much more! With contributions from nearly 50 international experts and containing over 1300 literature references, drawings, photographs, tables, and equations, Radioimmunotherapy of Cancer is an invaluable and indispensable reference for physicians in nuclear medicine and medical physicists; oncologists, radiologists, radiochemists, and radiopharmacists; immunologists, pulmonologists, and cancer researchers; pharmacologists and drug delivery pharmaceutical chemists; and upper-level undergraduate, graduate, and medical school students in these disciplines.

Fundamentals of Nuclear Science and Engineering, Third Edition, presents the nuclear science concepts needed to understand and quantify the whole range of nuclear phenomena. Noted for its accessible level and approach, the Third Edition of this long-time bestselling textbook provides overviews of nuclear physics, nuclear power, medicine, propulsion, and radiation detection. Its flexible organization allows for use with Nuclear Engineering majors and those in other disciplines. The Third Edition features updated coverage of the newest nuclear reactor designs, fusion reactors, radiation health risks, and expanded discussion of basic reactor physics with added examples. A complete Solutions Manual and figure slides for classroom projection are available for instructors adopting the text.