A Roadmap For Curing Cancer Alzheimer S And Cardiovascular Disease

Cancer, dementia, and cardiovascular disease are responsible for almost two million deaths each year in the United States alone and represent the largest immediate threat to humanity. Over the last century, we have made spectacular advances that have transformed our society – splitting the atom, space travel, telecommunications, and the Internet – but with medical research focused mostly on science for the sake of science, it has yielded precious few cures. A Roadmap for Curing Cancer, Alzheimer’s, and Cardiovascular Disease represents a "first of its kind" effort to address both the reasons for this and to posit solutions to fix our broken system, in an effort to finally end this cure crisis. Dr. Marangos draws on 45 years of experience in every aspect of the biomedical R&D field, from basic drug discovery research at the NIH to the co-founding of five drug companies. He has published 252 research papers and edited four books on drug discovery, is co-inventor on 14 patents, and founded "The Journal of Molecular Neuroscience". He argues that from a development perspective, the regulatory, patent, and legal hurdles that force industry to pursue so-called "me-too" drugs rather than cures for terminal diseases must be re-thought. Leadership accountability, strategy, focus, and urgency need to be re-evaluated, and major reforms to the NIH, FDA, and patent codes are proposed.to remedy these impediments to cures. Written for anyone frustrated with the seemingly endless threat of terminal disease, this book seeks to inform, energize, and provide the rationale for the public and industry stakeholders, as well as clinicians and researchers, to resurrect the physician-patient relationship and demand that we get serious about ridding society of this scourge on humanity. - This work contains the views and opinions of the author and are in no way intended to harm the reputation of any person, agency, organization, or commercial entity discussed herein. - First comprehensive analysis of the failures in curing cancer, Alzheimer’s, and cardiovascular disease with solutions proposed Defines deficiencies in academic life science research, including conflicting incentives, QA/QC issues, and how to fix them Provides a rationale for FDA reform especially as it relates to terminal disease drugs Details how a reformed NIH, regulators, and industry can partner to form a NASA-type effort to speed cures of terminal diseases Provides the first detailed roadmap for life science researchers to conquer terminal disease

In this "must-read" guide (Lonnie Ali), four leading doctors and advocates offer a bold action plan to prevent, care for, and treat Parkinson's disease-one of the great health challenges of our time. Brain diseases are now the world's leading source of disability. The fastest growing of these is Parkinson's: the number of impacted patients has doubled to more than six million over the last twenty-five years and is projected to double again by 2040. Harmful pesticides that increase the risk of Parkinson's continue to proliferate, many people remain undiagnosed and untreated, research funding stagnates, and the most effective treatment is now a half century old. In Ending Parkinson's Disease, four top experts provide a plan to help prevent Parkinson's, improve care and treatment, and end the silence associated with this devastating disease.

Chronic disease states of aging should be viewed through the prism of metabolism and biophysical processes at all levels of physiological organization present in the human body. This book describes the building blocks of understanding from a reasonable but not high-level technical language viewpoint, employing the perspective of a clinical physician. It brings together concepts from five specific branches of physics relevant to biology and medicine, namely, biophysics, classical electromagnetism, thermodynamics, systems biology and quantum mechanics. Key Features: Broad and up-to-date overview of the field of metabolism, especially connecting the spectrum of topics that range from modern physical underpinnings with cell biology to clinical practice. Provides a deeper basic science and interdisciplinary understanding of biological systems that broaden the perspectives and therapeutic problem solving. Introduces the concept of the Physiological Fitness Landscape, which is inspired by the physics of phase transitions This first volume in a two-volume set, primarily targets an audience of clinical and science students, biomedical researchers and physicians who would benefit from understanding each other’s language.