Abs Revealed

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Taking an interdisciplinary approach that emphasizes the adaptability of immunochemical and related bioanalytical methods to a variety of matrices, Immunoassay and Other Bioanalytical Techniques describes the strength and the versatility of these methods in a wide range of environmental and biological measurement applications. With contribut

Over the course of the previous seven editions, Pediatric Nephrology has become the standard reference text for students, trainees, practicing physicians (pediatricians, nephrologists, internists, and urologists), subspecialists, and allied health professionals seeking information about children’s kidney diseases. It is global in perspective, reflecting the fact that the international group of editors are all acknowledged world experts. The latest edition of this text is no different, providing a comprehensive, state-of-the-art overview on pediatric nephrology. Much like the previous edition, the latest edition reviews the most critical aspects of the field. Topics covered include developmental physiology and diseases, renal physiology and diagnostic approaches, glomerular disease, kidney involvement in systemic diseases, renal tubular disorders, homeostasis, cystic kidney disease and related disorders, urinary tract disorders, hypertension, acute kidney injury, and chronic kidney failure. Unlike the previous edition, however, the chapters in this edition now combine physiology, clinical management, and pathology for ease of use. The latest edition also includes a new section on the evaluation of different disorders that can have multiple etiologies, setting the stage for the evaluation and management of specific diseases. This book serves as a superb resource and an invaluable asset for practitioners, health professionals, and trainees seeking out information about children's kidney diseases.

Despite being an accepted construct in traffic and transport psychology, the precise nature of behavioural adaptation, including its causes and consequences, has not yet been established within the road safety community. A comprehensive collection of recent literature, Behavioural Adaptation and Road Safety: Theory, Evidence, and Action explores behavioural adaptation in road users. It examines behavioural adaptation within the context of historical and theoretical perspectives, and puts forth tangible—and practical—solutions that can effectively address adverse behavioural adaptation to road safety interventions before it occurs. Edited by Christina Rudin-Brown and Samantha Jamson, with chapters authored by leading road safety experts in driver psychology and behaviour, the book introduces the concept of behavioural adaptation and details its more relevant issues. It reviews the definition of behavioural adaptation that was put forward by the OECD in 1990 and then puts this definition through its paces, identifying where it may be lacking and how it might be improved. This sets the context for the remaining chapters which take the OECD definition as their starting points. The book discusses the various theories and models of behavioural adaptation and more general theories of driver behaviour developed during the last half century. It provides examples of the "evidence" for behavioural adaptation—instances in which behavioural adaptation arose as a consequence of the introduction of safety countermeasures. The book then focuses on the internal, "human" element and considers countermeasures that might be used to limit the development of behavioural adaptation in various road user groups. The book concludes with practical tools and methodologies to address behavioural adaptation in research and design, and to limit the potential negative effects before they happen. Supplying easy-to-understand, accessible solutions that can be implemented early on in a road safety intervention’s design or conception phase, the chapters represent the most extensive compilation of literature relating to behavioural adaptation and its consequences since the 1990 OECD report. The book brings together earlier theories of behavioural adaptation with more recent theories in the area and combines them with practical advice, methods, and tangible solutions that can minimise the potential negative impact of behavioural adaptation on road user safety and address it before it occurs. It is an essential component of any road safety library, and should be of particular relevance to researchers, practitioners, designers, and policymakers who are interested in maximizing safety while at the same time encouraging innovation and excellence in road transport-related design.

Many pathogens and aberrant malignant cells express unique carbohydrates on their surface representing attractive targets for vaccine design. Considerable progress has recently been made in the identification of novel carbohydrate based vaccines and a large number has reached clinical phase studies. The success of several licensed carbohydrate based vaccines against bacterial pathogens such as Haemophilus influenzae type b, Neisseria meningitidis or Streptococcus pneumoniae demonstrates their great potential. However, the study of anti-carbohydrate antibodies is technically challenging and partly because of low affinities and promiscuous specificity they have not been medically exploited to full potential. The study of antibody specificities and identification of protective carbohydrate epitopes lies at the heart of successful vaccine design. In addition to therapy, antibodies in general serve as diagnostic tools in medical and scientific laboratories. In this setting high affinity and exquisite specificity are important factors for their successful use. “Anticarbohydrate Antibodies – from molecular basis to clinical application” compiles current knowledge on the immunological recognition of carbohydrates by the adaptive immune system from a molecular perspective providing fundamental insight needed for advancing clinically relevant diagnostics and therapeutic applications. Based on significant progress in the fields of glycoimmunology and structural biology in recent years, the book comprehensively reviews the state-of-the-art in defining the key elements of carbohydrate recognition by antibodies, the molecular mimicry of carbohydrate epitopes as well as the molecular features leading to specific and relaxed binding modes. Backed-up by a combination of modern technologies to elucidate structural details of carbohydrate-antibody interactions, biomedically important carbohydrate antigens from viral, bacterial, parasite, insect and tumor cells have been analyzed in in-depth reviews written by well-known experts in the field. Fundamental knowledge of these molecular mechanisms eventually provides a rational basis to improve efficacy of carbohydrate-based vaccines and to further refine diagnostic tools in detection of pathogens and malignant cells.

The automotive sector has taken a keen interest in lightweighting as new required performance standards for fuel economy come into place. This strategy includes parts consolidation, design optimization, and material substitution, with sustainable polymers playing a major role in reducing a vehicle's weight. Sustainable polymers are largely biodegradable, biocompatible, and sourced from renewable plant and agricultural stocks. A facile way to enhance their properties, so they can indeed replace the ones made from fossil fuels, is by reinforcing them with fibers to make composites. Natural fibers are gaining more acceptance in the industry due to their renewable nature, low cost, low density, low energy consumption, high specific strength and stiffness, CO2 sequestration potential, biodegradability, and less wear imposed on machinery. Biocomposites then become a very feasible way to help address the fuel consumption challenge ahead of us. This book, entitled Biocomposites in Automotive Applications, is segmented into three sections and includes eleven hand-picked technical papers covering: * Processing and characterization of biocomposites * Automotive applications of biocomposites * A perspective on automotive sustainability It is a must read for those interested in the growing importance of composites used in automotive applications and their impact on sustainable mobility.

Autoimmune disease represents a group of more than 60 different chronic autoimmune diseases that affect approximately 6% of the population. Autoimmune diseases arise when ones immune system actively targets and destroys self tissue resulting in clinical disease with prime examples such as Lupus and Type 1 diabetes. The immune system is designed to protect us from foreign pathogens such as viruses and bacteria. However, during the process of generating immune cells for this purpose, as a negative consequence, self-reactive immune cells are also generated. This book aims to present the latest knowledge and insights regarding the different contributing factors and their interplay, discussions on several autoimmune diseases and their case studies, and therapeutic treatments, including stem cell, for autoimmune diseases.